Why is this medication prescribed?

Haegarda is prescribed for the prevention of hereditary angioedema (HAE) attacks in adolescents and adults. Hereditary angioedema is a genetic disorder characterized by recurrent episodes of swelling in various parts of the body, including the face, limbs, airway, and intestines.

HAE is caused by a deficiency or dysfunction of C1 esterase inhibitor (C1-INH), which is a protein involved in regulating certain substances in the body, particularly those involved in inflammation and swelling. Without sufficient levels of functional C1-INH, excessive swelling can occur, leading to painful and potentially life-threatening HAE attacks.

Haegarda contains a plasma-derived form of C1 esterase inhibitor, which is administered to replace the missing or malfunctioning protein in individuals with HAE. By replenishing C1-INH levels, Haegarda helps regulate the body’s inflammatory response, reducing the frequency and severity of HAE attacks.

It’s important to note that Haegarda is not used to treat acute HAE attacks once they have already occurred. It is specifically prescribed as a preventive therapy to minimize the occurrence of attacks and to provide ongoing protection against HAE-related swelling.

How should this medicine be used?

Haegarda is a prescription medication that is administered subcutaneously, which means it is injected under the skin. Here are general instructions for how Haegarda should be used, but it’s important to note that specific dosing and administration instructions may vary depending on individual factors and the guidance of a healthcare professional. Always follow the instructions provided by your healthcare provider or refer to the medication’s prescribing information.

• Preparation: Before using Haegarda, ensure that you have been trained by a healthcare professional on the proper administration technique. Wash your hands thoroughly with soap and water. Gather all the necessary supplies, including the Haegarda vial, a syringe, and sterile alcohol swabs.
• Vial reconstitution: Haegarda is supplied as a lyophilized powder in a vial. Reconstitute the powder with the appropriate volume of sterile water for injection as instructed by your healthcare professional. Gently swirl the vial until the powder is completely dissolved. Do not shake the vial vigorously to avoid foaming or denaturing the protein.
• Drawing the solution: After reconstitution, inspect the solution to ensure it is clear, colorless, and free of particles. Withdraw the prescribed amount of Haegarda solution into a syringe. Your healthcare professional will determine the appropriate dosage based on your specific needs.
• Injection site preparation: Select an injection site, typically on the abdomen, thighs, or upper arms. Clean the injection site with a sterile alcohol swab and allow it to dry before proceeding.
• Injection: Pinch the cleaned skin at the selected injection site to create a small fold or “tent.” Hold the syringe with one hand and insert the needle into the folded skin at a 45- to 90-degree angle. Slowly inject the Haegarda solution and then withdraw the needle from the skin. Do not rub the injection site after the injection.
• Disposal: Safely dispose of used syringes, needles, and any remaining medication as instructed by your healthcare professional or local guidelines.

It’s important to adhere to the prescribed dosing schedule and follow any additional instructions provided by your healthcare professional. If you have any questions or concerns regarding the administration of Haegarda, consult your healthcare provider for clarification and guidance.

Other uses for this medicine

Haegarda is specifically approved for the prevention of hereditary angioedema (HAE) attacks and does not have other approved uses. It is important to use Haegarda only as prescribed by your healthcare provider and for the indicated purpose.

What special precautions should I follow?

When using Haegarda, it is essential to follow certain precautions. Here are some general considerations, but it’s important to consult with your healthcare provider or refer to the medication’s prescribing information for specific precautions based on your individual circumstances:

• Allergies: Inform your healthcare provider if you have any known allergies, especially if you are allergic to any components of Haegarda. Reactions to Haegarda are rare, but it’s important to discuss any potential allergies with your doctor.
• Infections: Haegarda is made from human plasma, and like other plasma-derived products, it carries a theoretical risk of transmitting infectious agents, although rigorous screening and manufacturing processes are implemented to minimize this risk. However, the risk of transmission of infectious agents cannot be entirely eliminated. Inform your healthcare provider about any infections you have or have had, as well as if you have a known history of blood-borne diseases.
• Pregnancy and breastfeeding: The safety and effectiveness of Haegarda during pregnancy or while breastfeeding have not been established. If you are pregnant, planning to become pregnant, or breastfeeding, discuss the potential risks and benefits with your healthcare provider before using Haegarda.
• Interactions with other medications: Inform your healthcare provider about all the medications, supplements, or herbal products you are currently taking or planning to take, as certain medications may interact with Haegarda and affect its effectiveness or increase the risk of side effects.
• Adverse reactions: Although uncommon, allergic reactions or hypersensitivity to Haegarda can occur. If you experience any signs of an allergic reaction, such as difficulty breathing, rash, itching, or swelling, seek immediate medical attention.
• Injection site reactions: Like with any subcutaneous injection, there is a possibility of local injection site reactions, such as redness, swelling, or bruising. Report any persistent or worsening injection site reactions to your healthcare provider.

Always consult your healthcare provider for personalized advice and guidance on the proper precautions to take while using Haegarda. They can provide you with the most up-to-date information based on your specific medical history and needs.

What special dietary instructions should I follow?

There are no specific dietary restrictions associated with Haegarda. However, maintaining a healthy, well-balanced diet is generally beneficial for overall health. Eating a diet rich in fruits, vegetables, lean proteins, and whole grains can help support your immune system and overall well-being.

What should I do if I forget a dose?

If you forget to take a dose of Haegarda, it is important to contact your healthcare provider or follow their specific instructions. They will be able to provide you with guidance based on your individual circumstances. It is generally recommended to take the missed dose as soon as you remember, and then resume your regular dosing schedule. However, it’s important to consult your healthcare provider to determine the appropriate course of action.

What side effects can this medication cause?

Haegarda is a medication used for the prevention of hereditary angioedema (HAE) attacks in patients aged 12 years and older. Like any medication, Haegarda can cause side effects, although not everyone experiences them. It’s important to discuss potential side effects with your healthcare provider before starting Haegarda. Here are some commonly reported side effects associated with Haegarda:

• Injection-site reactions: These can include redness, itching, pain, swelling, or bruising at the injection site. These reactions are usually mild and temporary.
• Headache: Some individuals may experience headaches while taking Haegarda. If the headaches are severe or persistent, it’s important to notify your healthcare provider.
• Nausea and vomiting: These gastrointestinal symptoms can occur but are generally mild and temporary.
• Diarrhea: Some individuals may experience diarrhea while taking Haegarda. If the diarrhea is severe or persistent, it’s important to notify your healthcare provider.
• Fever: In some cases, Haegarda may cause a mild fever. If the fever persists or becomes severe, you should consult your healthcare provider.

It’s important to note that these are not the only possible side effects of Haegarda. Different individuals may have different reactions to the medication. If you experience any unusual or severe symptoms while taking Haegarda, it’s important to contact your healthcare provider for further evaluation and guidance. They will be able to provide you with more specific information regarding potential side effects based on your individual circumstances.

What should I know about storage and disposal of this medication?

1. Storage: Haegarda should be stored in a refrigerator at a temperature between 2°C and 8°C (36°F and 46°F). The medication should not be frozen. Keep the product in its original carton to protect it from light. Do not use Haegarda beyond the expiration date printed on the carton or vial.
2. Disposal: Discard any unused or expired Haegarda according to the guidelines provided by your healthcare provider or local regulations. It is important not to dispose of Haegarda in household waste or down the drain. Consult with your pharmacist or healthcare provider for specific instructions on the proper disposal method in your area.

In case of emergency/overdose

• In case of an emergency or overdose, contact your local emergency services (such as 911 in the United States) or seek immediate medical attention.
• It’s important to inform healthcare professionals about the specific medication taken, including Haegarda, and provide them with any relevant details.

What other information should I know?

• Haegarda is a prescription medication and should only be used under the supervision and guidance of a healthcare professional.
• Inform your healthcare provider about any other medications, supplements, or herbal products you are taking, as they may interact with Haegarda.
• Inform your healthcare provider about any known allergies or sensitivities to medications.
• Attend all scheduled appointments with your healthcare provider to monitor your condition and response to Haegarda.
• It’s important to follow the administration instructions provided by your healthcare provider or the prescribing information for Haegarda.

These are general guidelines, and it’s important to consult your healthcare provider or refer to the specific instructions provided with your medication for accurate and personalized information regarding storage, disposal, emergencies, and other relevant details associated with Haegarda.