Why is this medication prescribed?

H.P. Acthar Gel is prescribed for several medical conditions due to its anti-inflammatory and immunomodulatory properties. Here are some of the reasons why it may be prescribed:

• Multiple Sclerosis (MS): H.P. Acthar Gel is used for the treatment of acute exacerbations of MS in adults. It helps reduce inflammation and shorten the duration of relapses.
• Nephrotic Syndrome: It can be prescribed for the treatment of nephrotic syndrome, a kidney disorder characterized by excessive protein excretion in the urine. H.P. Acthar Gel helps reduce proteinuria and stabilize the condition.
• Rheumatic Disorders: H.P. Acthar Gel may be prescribed for certain rheumatic conditions, including rheumatoid arthritis, systemic lupus erythematosus (SLE), and dermatomyositis/polymyositis. It helps reduce inflammation and modulate the immune response.
• Ophthalmic Conditions: In certain severe allergic and inflammatory eye conditions, such as uveitis, H.P. Acthar Gel may be used to reduce inflammation and promote healing.
• Respiratory Disorders: H.P. Acthar Gel can be prescribed for respiratory conditions like sarcoidosis and symptomatic sarcoidosis, where it helps reduce inflammation in the affected organs.

It’s important to note that H.P. Acthar Gel is a potent medication and should only be used under the guidance and supervision of a healthcare professional. The decision to prescribe H.P. Acthar Gel is based on the specific condition being treated and the patient’s individual circumstances.

How should this medicine be used?

H.P. Acthar Gel is typically administered as an injection and should be used according to the instructions provided by your healthcare professional. Here are some general guidelines for using H.P. Acthar Gel:

• Administration: H.P. Acthar Gel is usually given as a subcutaneous injection (under the skin) or as an intramuscular injection (into the muscle). The specific administration method will be determined by your healthcare provider.
• Dosage: The dosage of H.P. Acthar Gel can vary depending on the condition being treated and individual patient factors. Your healthcare provider will determine the appropriate dosage for you. It is important to follow their instructions carefully.
• Injection Technique: If you are self-administering the injection, make sure to follow proper injection techniques. Your healthcare provider will provide instructions on how to correctly prepare and administer the injection. They may also provide a demonstration or written instructions for reference.
• Site Rotation: If you are giving yourself multiple injections, it is important to rotate the injection sites. This helps prevent skin and tissue damage that can occur from repeated injections in the same area. Your healthcare provider will guide you on proper site rotation.

Other uses for this medicine

H.P. Acthar Gel (repository corticotropin injection) is a medication primarily used for the treatment of various inflammatory and autoimmune conditions. However, it may also have other off-label uses depending on the judgment of the prescribing healthcare professional. Some of the off-label uses that have been reported include:

• Nephrotic syndrome: Acthar Gel may be used to treat nephrotic syndrome, a kidney disorder characterized by excessive protein loss in the urine.
• Rheumatologic conditions: It can be considered for certain rheumatologic conditions such as rheumatoid arthritis, systemic lupus erythematosus, and dermatomyositis.
• Ophthalmic disorders: Acthar Gel may be used in the management of certain ophthalmic conditions like uveitis, which involves inflammation of the uvea (middle layer of the eye).
• Multiple sclerosis: It is sometimes used as an alternative treatment for multiple sclerosis (MS) exacerbations, particularly when other options have failed.
• Allergic and skin disorders: Acthar Gel may be utilized in the treatment of severe allergic reactions and certain skin disorders, including pemphigus vulgaris and erythema multiforme.
• Respiratory conditions: It might be considered for the treatment of respiratory conditions such as sarcoidosis and hypersensitivity pneumonitis.
• Infantile spasms: Acthar Gel may be used as a treatment option for infantile spasms, a type of epilepsy that typically affects infants between 4 and 8 months old.

What special precautions should I follow?

Regarding precautions, it is essential to follow the instructions provided by your healthcare provider and adhere to the prescribed dosage. Here are some general precautions associated with Acthar Gel:

• Allergies: Inform your healthcare provider if you have any known allergies, particularly to corticotropin or any other components of Acthar Gel.
• Medical history: Provide your healthcare provider with a comprehensive medical history, including any previous or current medical conditions, infections, or other health issues.
• Pregnancy and breastfeeding: Discuss with your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding, as Acthar Gel use during these periods should be carefully considered.
• Interactions: Inform your healthcare provider about all the medications, supplements, or herbal products you are currently taking, as Acthar Gel may interact with certain drugs.
• Side effects: Be aware of the potential side effects associated with Acthar Gel and report any unusual or severe symptoms to your healthcare provider promptly.
• Monitoring: Your healthcare provider may monitor you closely during the course of Acthar Gel treatment to assess its effectiveness and manage any potential side effects.

Remember, this information is not exhaustive, and it’s crucial to consult your healthcare provider for personalized guidance and advice regarding the use of H.P. Acthar Gel.

What special dietary instructions should I follow?

There are no specific dietary instructions associated with H.P. Acthar Gel (repository corticotropin injection). However, it is generally recommended to follow a healthy and balanced diet while undergoing any medical treatment. Eating a nutritious diet can support overall health and well-being.

What should I do if I forget a dose?

If you forget to take a dose of Acthar Gel, it is important to consult your healthcare provider or pharmacist for guidance. They can provide specific instructions based on your individual circumstances. In general, if you miss a dose:

• Take the missed dose as soon as you remember: If you realize that you have missed a dose and it is not close to the time for your next scheduled dose, take the missed dose as soon as possible. Then continue with your regular dosing schedule.
• Skip the missed dose if it’s almost time for the next dose: If it is close to the time for your next scheduled dose, it is generally recommended to skip the missed dose and continue with your regular dosing schedule. Taking a double dose to make up for the missed one is not advisable

What side effects can this medication cause?

H.P. Acthar Gel (repository corticotropin injection) is a medication that contains adrenocorticotropic hormone (ACTH) and is used to treat various conditions such as multiple sclerosis, infantile spasms, and certain autoimmune disorders. Like any medication, Acthar Gel can cause side effects. Some common side effects of Acthar Gel include:

• Injection site reactions: This may include pain, redness, swelling, or bruising at the injection site.
• Increased blood pressure: Acthar Gel can cause an increase in blood pressure, which may require monitoring or adjustment of blood pressure medications.
• Fluid retention and swelling: Acthar Gel can cause fluid retention, leading to swelling in various parts of the body, such as the face, hands, ankles, or feet.
• Increased blood sugar levels: Acthar Gel can raise blood sugar levels, which may be of concern for individuals with diabetes or those at risk of developing diabetes.
• Mood and behavior changes: Acthar Gel may cause mood swings, irritability, anxiety, or changes in behavior.
• Weight gain: Some individuals may experience weight gain while taking Acthar Gel.
• Gastrointestinal effects: Acthar Gel can cause stomach upset, nausea, and increased appetite.
• Suppression of the adrenal glands: Prolonged use of Acthar Gel can lead to adrenal gland suppression, which may require gradual tapering of the medication.

It’s important to note that not all individuals will experience these side effects, and the severity and frequency of side effects can vary. Additionally, there may be other potential side effects not listed here. If you are prescribed Acthar Gel, it’s crucial to discuss potential side effects with your healthcare provider and report any unusual or concerning symptoms promptly.

What should I know about storage and disposal of this medication?

Guaifenesin is an over-the-counter medication commonly used as an expectorant to help loosen mucus and phlegm in the chest and throat. Here’s some important information regarding the storage and disposal to Guaifenesin:

Storage:

• Read and follow the storage instructions provided on the packaging or as directed by your healthcare provider.
• Store Guaifenesin at room temperature, away from excessive heat, moisture, and direct sunlight.
• Keep it out of reach and sight of children and pets.

Disposal:

• Check the packaging or consult your local regulations regarding the proper disposal of medications. Do not dispose of Guaifenesin down the drain or toilet unless instructed to do so.
• If no specific instructions are given, consider taking unused or expired Guaifenesin to a drug take-back program or a pharmacy that offers medication disposal services.

In case of emergency/overdose

• In case of an emergency or suspected overdose, immediately contact your local emergency services (e.g., call 911 in the United States) or your regional poison control center.
• Be prepared to provide relevant information such as the person’s age, weight, the amount of Guaifenesin taken (if known), and the time of ingestion.
• If possible, have the Guaifenesin packaging or container available for reference.
• Do not induce vomiting unless instructed to do so by medical professionals

What other information should I know?

• Follow the recommended dosage and usage instructions provided on the packaging or as advised by your healthcare provider. Do not exceed the recommended dose unless instructed by a healthcare professional.
• If you have any pre-existing medical conditions, are taking other medications, or are pregnant or breastfeeding, consult your healthcare provider before using Guaifenesin.
• Inform your healthcare provider about any allergies or sensitivities you may have, as Guaifenesin may contain inactive ingredients that could cause an allergic reaction.
• If your symptoms persist or worsen after using Guaifenesin, or if you develop new symptoms, seek medical advice.

Remember, this information serves as a general guideline. Always read the packaging and consult your healthcare provider or pharmacist for specific instructions and advice regarding the use, storage, and disposal of Guaifenesin.