Why is this medication prescribed?

Gocovri (amantadine) is primarily prescribed for the treatment of dyskinesia, which is a movement disorder characterized by involuntary muscle movements. It is specifically indicated for patients with Parkinson’s disease who experience dyskinesia as a side effect of levodopa/carbidopa therapy.

Dyskinesia often occurs as a complication of long-term treatment with levodopa, a medication commonly used to manage the motor symptoms of Parkinson’s disease. Gocovri works by modulating the release of certain neurotransmitters in the brain, helping to reduce the severity of dyskinesia and improve motor control in patients with Parkinson’s disease.

In addition to dyskinesia, Gocovri may also be prescribed for the management of other symptoms associated with Parkinson’s disease, such as tremors and rigidity. It is typically used as an adjunctive therapy alongside other medications prescribed for Parkinson’s disease management.

How should this medicine be used?

Gocovri (amantadine) should be used exactly as prescribed by your healthcare provider. Here are general guidelines for using Gocovri:

• Dosage: Take Gocovri according to the dosage prescribed by your healthcare provider. The typical starting dose is 137 mg once daily in the morning. Your doctor may adjust the dose based on your individual response and tolerability.
• Administration: Swallow the Gocovri capsule whole with a full glass of water. Do not crush, chew, or break the capsule.
• Timing: Gocovri is usually taken once daily in the morning. Try to take it at the same time each day to maintain consistent levels of the medication in your body.
• Food: Gocovri can be taken with or without food. You can take it with or without a meal based on your preference or as instructed by your healthcare provider.
• Other medications: Inform your healthcare provider about all other medications, supplements, and herbal products you are taking, as Gocovri may interact with certain medications.
• Do not stop suddenly: Do not stop taking Gocovri suddenly without consulting your healthcare provider, as this can lead to withdrawal symptoms or worsening of symptoms. If you and your doctor decide to discontinue Gocovri, your dose should be gradually reduced under medical supervision.
• Follow-up: Attend all follow-up appointments with your healthcare provider to monitor your response to Gocovri and to make any necessary adjustments to your treatment plan.
• Side effects: Be aware of potential side effects of Gocovri and report any unusual symptoms or concerns to your healthcare provider promptly.

Remember to always follow your healthcare provider’s instructions carefully when using Gocovri or any other medication. If you have any questions or concerns about how to use Gocovri, do not hesitate to discuss them with your doctor or pharmacist.

Other uses for this medicine

While Gocovri (amantadine) is primarily prescribed for the treatment of dyskinesia associated with Parkinson’s disease, it may also have off-label uses or be prescribed for other conditions by healthcare providers. Off-label uses may include the treatment of fatigue in multiple sclerosis, bipolar disorder, depression, and ADHD (attention-deficit/hyperactivity disorder). However, it’s important to note that the effectiveness and safety of Gocovri for these off-label uses may vary, and you should only take it as prescribed by your healthcare provider.

What special precautions should I follow?

As for special precautions when using Gocovri, consider the following:

• Medical history: Inform your healthcare provider about your complete medical history, especially if you have a history of seizures, heart problems, kidney disease, liver disease, psychiatric disorders, or any allergies.
• Medication interactions: Gocovri may interact with other medications, including anticholinergic drugs, dopamine agonists, and medications that affect the central nervous system. Inform your healthcare provider about all the medications, supplements, and herbal products you are currently taking to avoid potential interactions.
• Pregnancy and breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss the risks and benefits of using Gocovri with your healthcare provider. It is important to weigh the potential risks to the fetus or infant against the potential benefits of treatment.
• Driving and operating machinery: Gocovri may cause dizziness, lightheadedness, or blurred vision, which can impair your ability to drive or operate machinery safely. Use caution when performing tasks that require mental alertness or coordination until you know how Gocovri affects you.
• Alcohol: Avoid excessive alcohol consumption while taking Gocovri, as it may increase the risk of side effects such as dizziness or drowsiness.
• Heat exposure: Gocovri may increase the risk of overheating or heat stroke, especially in hot weather or during strenuous physical activity. Stay hydrated and avoid prolonged exposure to heat or sunlight, particularly if you are unable to perspire normally.
• Missed doses: If you miss a dose of Gocovri, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
• Side effects: Be aware of potential side effects of Gocovri, such as nausea, dizziness, insomnia, hallucinations, and swelling of the ankles. If you experience any concerning symptoms, contact your healthcare provider promptly.

It’s crucial to follow your healthcare provider’s instructions and guidelines for using Gocovri, and to report any concerns or adverse reactions promptly. Your doctor can provide personalized advice and monitor your response to treatment to ensure your safety and well-being.

What special dietary instructions should I follow?

Regarding special dietary instructions for Gocovri, there are no specific dietary restrictions associated with its use. However, it’s always a good idea to maintain a balanced diet and stay hydrated, especially if you’re experiencing any side effects such as nausea or loss of appetite. If you have any concerns about your diet while taking Gocovri, discuss them with your healthcare provider or a registered dietitian.

What should I do if I forget a dose?

If you forget a dose of Gocovri, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you have any concerns or questions about missed doses, consult your healthcare provider for guidance.

What side effects can this medication cause?

Gocovri (amantadine) can cause various side effects, ranging from mild to severe. Not everyone will experience these side effects, and their severity may vary from person to person. Common side effects of Gocovri include:

• Nausea
• Dizziness
• Dry mouth
• Difficulty sleeping (insomnia)
• Hallucinations
• Lightheadedness
• Blurred vision
• Swelling of the ankles
• Constipation
• Anxiety
• Loss of appetite
• Impaired coordination or balance

Less common but more severe side effects may include:

• Seizures
• Confusion or disorientation
• Depression or suicidal thoughts
• Agitation or aggression
• Difficulty urinating
• Skin rash or allergic reactions
• Changes in heart rate or rhythm
• Unusual muscle movements or stiffness
• Difficulty breathing

If you experience any concerning side effects while taking Gocovri, it’s important to contact your healthcare provider promptly. They can provide guidance, adjust your dosage, or switch you to a different medication if necessary. Additionally, if you have a history of certain medical conditions or are taking other medications, you may be at a higher risk of experiencing certain side effects, so it’s essential to discuss your medical history and current medications with your healthcare provider before starting Gocovri.

What should I know about storage and disposal of this medication?

Storage and disposal of Gocovri:

• Storage: Store Gocovri capsules at room temperature away from moisture, heat, and light. Keep the medication in its original container, tightly closed, and out of reach of children and pets.
• Disposal: Dispose of unused or expired Gocovri capsules properly according to local regulations or guidelines. Do not flush medications down the toilet or pour them down the drain unless instructed to do so. If you have questions about proper disposal, consult your healthcare provider or pharmacist.

In case of emergency/overdose

In case of an overdose of Gocovri, seek emergency medical attention or contact a poison control center immediately. Overdose symptoms may include confusion, hallucinations, agitation, seizures, rapid heartbeat, difficulty breathing, and loss of consciousness.

What other information should I know?

• Gocovri may cause dizziness, lightheadedness, or blurred vision. Use caution when performing tasks that require mental alertness or coordination until you know how Gocovri affects you.
• Avoid sudden discontinuation of Gocovri without consulting your healthcare provider, as it may lead to withdrawal symptoms or worsening of symptoms.
• Inform all healthcare providers involved in your care (doctors, dentists, pharmacists, etc.) about your use of Gocovri to prevent potential interactions with other medications or procedures.
• Attend all follow-up appointments with your healthcare provider to monitor your response to Gocovri and make any necessary adjustments to your treatment plan.
• Keep a list of all medications you are taking, including prescription and over-the-counter drugs, as well as any supplements or herbal products, and share this information with your healthcare provider.
• If you have any questions or concerns about Gocovri or your treatment plan, do not hesitate to discuss them with your healthcare provider or pharmacist.

It’s essential to follow all instructions provided by your healthcare provider and to report any adverse reactions or concerns promptly. Your doctor can provide personalized guidance and support to ensure your safety and well-being while taking Gocovri.