WARNING

Glasdegib is a medication primarily used for the treatment of certain types of blood disorders, particularly acute myeloid leukemia (AML). Like any medication, it comes with potential risks and side effects. Some of the risks associated with taking Glasdegib include:

• Bone marrow suppression: Glasdegib can affect the bone marrow’s ability to produce blood cells, leading to conditions like anemia, neutropenia (low white blood cell count), and thrombocytopenia (low platelet count). This can increase the risk of infections, bleeding, and fatigue.
• Gastrointestinal issues: Common side effects of Glasdegib include nausea, vomiting, diarrhea, and loss of appetite. These symptoms can affect a person’s quality of life and may require supportive care or adjustments in medication.
• Liver toxicity: There is a risk of liver toxicity associated with Glasdegib, which may manifest as elevated liver enzyme levels or liver damage. Monitoring liver function is typically recommended during treatment.
• Musculoskeletal adverse events: Some individuals may experience muscle or joint pain while taking Glasdegib. This can range from mild discomfort to more severe pain that interferes with daily activities.
• Cardiovascular effects: Glasdegib has been associated with an increased risk of QT interval prolongation, which can lead to abnormal heart rhythms. Patients with a history of heart conditions or those taking other medications that prolong the QT interval may be at higher risk.
• Embryo-fetal toxicity: Glasdegib can cause harm to developing fetuses if taken during pregnancy. Therefore, it is contraindicated in pregnancy, and effective contraception is recommended for both males and females during treatment and for a period after discontinuation.
• Other potential side effects: Additional adverse reactions may occur with Glasdegib, including fatigue, headache, dizziness, rash, and fever. It’s essential for patients to communicate any unusual symptoms to their healthcare provider.

It’s important for individuals considering or currently taking Glasdegib to discuss potential risks and benefits with their healthcare provider. Close monitoring and management of side effects can help optimize treatment outcomes while minimizing adverse events.

Why is this medication prescribed?

Glasdegib is a medication prescribed for the treatment of certain types of blood disorders, particularly acute myeloid leukemia (AML) in adults who are not eligible for intensive chemotherapy. AML is a type of cancer that affects the bone marrow and blood cells.

Glasdegib works by inhibiting a protein called smoothened, which plays a role in the growth and development of cancer cells. By blocking this protein, glasdegib helps to slow down or stop the growth of cancer cells, thereby helping to treat the condition.

How should this medicine be used?

When using glasdegib, it’s crucial to follow your doctor’s instructions carefully. Typically, it is taken orally in the form of tablets. The dosage and frequency of administration will depend on various factors such as your medical condition, response to treatment, and any other medications you may be taking.

Usually, glasdegib is taken once daily with or without food. It’s essential to swallow the tablet whole with a full glass of water and not to crush, chew, or break it. If you have trouble swallowing tablets, speak with your doctor or pharmacist for advice.

It’s important not to adjust the dosage or stop taking glasdegib without consulting your doctor, even if you start feeling better. Missing doses can affect the effectiveness of the treatment.

As with any medication, glasdegib may cause side effects, so it’s essential to report any unusual symptoms or reactions to your doctor promptly. Additionally, your doctor will monitor your blood counts and other relevant parameters regularly to ensure the medication is working effectively and to manage any potential side effects.

Other uses for this medicine

While Glasdegib is primarily prescribed for the treatment of acute myeloid leukemia (AML), it may also be investigated for other potential uses in the future. Clinical trials and research studies are ongoing to explore its efficacy in other types of cancers or blood disorders.

What special precautions should I follow?

As for special precautions to follow when taking Glasdegib, it’s important to adhere to the following guidelines:

• Pregnancy and breastfeeding: Glasdegib can cause harm to developing fetuses and is contraindicated during pregnancy. Women of childbearing potential should use effective contraception during treatment and for a period after discontinuation. It is also not recommended for use while breastfeeding.
• Liver function: Since Glasdegib can potentially cause liver toxicity, regular monitoring of liver function tests is typically recommended during treatment. Patients should promptly report any symptoms of liver problems, such as jaundice (yellowing of the skin or eyes), abdominal pain, or dark urine, to their healthcare provider.
• Heart health: Glasdegib has been associated with an increased risk of QT interval prolongation, which can lead to abnormal heart rhythms. Patients with a history of heart conditions or those taking other medications that prolong the QT interval may be at higher risk. Close monitoring of cardiac function and periodic electrocardiograms (ECGs) may be warranted during treatment.
• Bone marrow suppression: Glasdegib can cause bone marrow suppression, leading to low blood cell counts (anemia, neutropenia, thrombocytopenia). Patients should be monitored for signs of infection, bleeding, or fatigue, and appropriate supportive care measures may be necessary.
• Drug interactions: Patients should inform their healthcare provider about all medications, supplements, and herbal products they are taking before starting Glasdegib. Some medications may interact with Glasdegib, potentially affecting its efficacy or increasing the risk of adverse reactions.
• Musculoskeletal effects: Patients may experience muscle or joint pain while taking Glasdegib. If these symptoms become severe or interfere with daily activities, patients should seek medical advice.
• Adverse reactions: Patients should be aware of potential side effects associated with Glasdegib and promptly report any unusual symptoms to their healthcare provider. These may include gastrointestinal issues (nausea, vomiting, diarrhea), fatigue, headache, rash, or fever.

It’s essential for patients to maintain open communication with their healthcare provider throughout treatment with Glasdegib and to follow their recommendations closely to optimize safety and efficacy.

What special dietary instructions should I follow?

There are no specific dietary restrictions associated with Glasdegib. However, it’s generally advisable to maintain a healthy, balanced diet to support overall health and well-being during cancer treatment. Eating a variety of fruits, vegetables, lean proteins, and whole grains can help provide essential nutrients and support the body’s ability to cope with treatment-related side effects.

What should I do if I forget a dose?

If you miss a dose of Glasdegib, take it as soon as you remember, unless it’s almost time for your next scheduled dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you’re unsure about what to do, contact your healthcare provider or pharmacist for advice. It’s essential to try to take Glasdegib consistently as prescribed to maximize its effectiveness in treating your condition.

What side effects can this medication cause?

Glasdegib, like many medications, can cause side effects. Common side effects associated with Glasdegib include:

• Nausea and vomiting: These gastrointestinal symptoms are among the most common side effects reported by patients taking Glasdegib. It’s typically advised to take Glasdegib with food to help reduce the likelihood of experiencing these symptoms.
• Diarrhea: Some individuals may experience diarrhea while taking Glasdegib. Staying hydrated and consuming a balanced diet can help manage this side effect.
• Fatigue: Feeling tired or fatigued is another common side effect of Glasdegib. It’s important to get enough rest and engage in gentle physical activity as tolerated to help combat fatigue.
• Muscle or joint pain: Glasdegib may cause muscle or joint pain in some patients. If these symptoms become bothersome, talk to your healthcare provider about possible management strategies.
• Decreased appetite: Some individuals may experience a decrease in appetite while taking Glasdegib. Eating small, frequent meals and choosing nutrient-dense foods can help maintain adequate nutrition.
• Headache: Headaches are reported by some patients taking Glasdegib. If headaches persist or worsen, discuss them with your healthcare provider.
• Rash: Skin rash or itching may occur as a side effect of Glasdegib. If you develop a rash, inform your healthcare provider for appropriate management.
• Fever: Fever is another possible side effect of Glasdegib. If you develop a fever, especially if it’s accompanied by other symptoms, notify your healthcare provider promptly.
• Abnormal liver function tests: Glasdegib can affect liver function, leading to elevated liver enzyme levels. Regular monitoring of liver function tests is typically recommended during treatment.
• QT interval prolongation: Glasdegib may cause prolongation of the QT interval on electrocardiograms (ECGs), which can increase the risk of abnormal heart rhythms. Patients with pre-existing heart conditions or those taking other medications that affect the QT interval may be at higher risk.

It’s essential to report any side effects you experience while taking Glasdegib to your healthcare provider. They can provide guidance on managing these side effects and determine if any adjustments to your treatment plan are necessary.

What should I know about storage and disposal of this medication?

Storage and disposal of Glasdegib:

• Storage: Store Glasdegib tablets at room temperature away from moisture and heat. Keep the medication in its original packaging and out of reach of children and pets.
• Disposal: Dispose of unused or expired Glasdegib tablets according to local regulations or guidelines. Do not flush them down the toilet or pour them down the drain unless instructed to do so. Consult with your pharmacist or healthcare provider for proper disposal methods, such as using a medication take-back program or a designated disposal container.

In case of emergency/overdose

In case of emergency/overdose of Glasdegib:

• Seek medical attention: If you suspect an overdose of Glasdegib or experience severe symptoms such as fainting, difficulty breathing, or irregular heartbeats, seek immediate medical assistance by calling emergency services or going to the nearest emergency room.
• Poison control: Contact your local poison control center or emergency department for guidance on what to do in case of an overdose. Be prepared to provide information about the amount of Glasdegib ingested and any symptoms experienced.

What other information should I know?

• Follow-up appointments: Attend all scheduled follow-up appointments with your healthcare provider while taking Glasdegib. Regular monitoring is important to assess treatment effectiveness and detect any potential side effects or complications.
• Patient support: Consider joining a support group for individuals with AML or other blood disorders. Connecting with others who are undergoing similar experiences can provide valuable emotional support and practical tips for coping with treatment.
• Medication adherence: Take Glasdegib exactly as prescribed by your healthcare provider. Do not alter your dosage or stop taking the medication without consulting them first, even if you feel better. Skipping doses or discontinuing treatment prematurely can reduce its effectiveness.
• Drug interactions: Inform your healthcare provider about all medications, supplements, and herbal products you are taking, as Glasdegib may interact with other drugs. Avoid starting any new medications without consulting your healthcare provider first.
• Travel considerations: If you plan to travel while taking Glasdegib, ensure you have an adequate supply of medication and any necessary medical documentation. Considerations such as time zone changes and access to healthcare services at your destination should also be taken into account.

If you have any questions or concerns about Glasdegib or its use, do not hesitate to consult your healthcare provider or pharmacist for guidance. They can provide personalized advice based on your individual health needs and circumstances.