WARNING

Studies have shown that older adults with dementia, a brain disorder that impairs memory, thinking clearly, communication, and daily functioning and may result in changes in mood and personality, who take antipsychotics, such as ziprasidone injection, have a higher risk of dying while receiving treatment. Additionally, older people with dementia may be more likely to get a stroke or mini-stroke while receiving treatment.

The Food and Drug Administration (FDA) has not approved ziprasidone injection for the management of behavioral issues in dementia-affected older individuals. If you, a member of your family, or someone you care for has dementia and is taking ziprasidone, speak with the doctor who prescribed it.

Discuss the dangers of obtaining an injection of ziprasidone with your doctor.

Why is this medication prescribed?

Ziprasidone injection is a medication that is primarily prescribed for the treatment of acute agitation in adults with schizophrenia. It belongs to a class of medications called atypical antipsychotics, which work by restoring the balance of certain chemicals in the brain.

When administered as an injection, ziprasidone provides rapid relief from agitation and aggressive behavior associated with schizophrenia. It is typically used in situations where immediate control of symptoms is necessary or when oral medications are not feasible or appropriate.

How should this medicine be used?

The specific dosage and duration of treatment with ziprasidone injection will vary depending on the individual’s condition and response to the medication. It is typically administered by healthcare professionals in a hospital or clinical setting. The injection is given into a muscle (intramuscularly) and may be repeated if necessary. The maximum recommended daily dose should not exceed 40 mg.

It’s important to note that ziprasidone injection is not intended for long-term maintenance treatment, and once the acute agitation is controlled, a switch to oral medications is usually made for continued treatment.

Other uses for this medicine

Ziprasidone is primarily used as an antipsychotic medication to treat conditions such as schizophrenia and bipolar disorder. However, there are no approved alternative uses for Ziprasidone injection beyond its intended purpose. It is important to consult with a healthcare professional regarding the appropriate use and indications of this medication.

What special precautions should I follow?

As for special precautions, here are some general guidelines:

• Medical History: Inform your healthcare provider about your complete medical history, especially if you have or have had any of the following conditions:
  • Heart problems or a history of heart attack or stroke
  • Low or high blood pressure
  • Seizures or epilepsy
  • Diabetes or a family history of diabetes
  • Liver or kidney problems
  • Blood disorders
  • Any allergies to medications
• Medications: Inform your healthcare provider about all the medications you are currently taking, including prescription drugs, over-the-counter medications, vitamins, and herbal supplements. This is important because certain medications can interact with Ziprasidone and cause adverse effects.
• Allergic Reactions: If you have ever had an allergic reaction to Ziprasidone or any other antipsychotic medication, inform your healthcare provider immediately. Allergic reactions may include rash, itching, swelling, severe dizziness, or difficulty breathing.
• Pregnancy and Breastfeeding: It is important to discuss the risks and benefits of using Ziprasidone during pregnancy or while breastfeeding. Your healthcare provider can guide you on the best course of action.
• Driving and Operating Machinery: Ziprasidone may cause drowsiness, dizziness, or blurred vision, which can impair your ability to drive or operate machinery. Avoid these activities until you know how the medication affects you.
• Alcohol and Sedatives: Avoid consuming alcohol or taking sedatives while using Ziprasidone, as they can enhance the sedative effects of the medication.

What special dietary instructions should I follow?

It’s important to consult with your healthcare provider or pharmacist for specific instructions regarding your medication. Here are some general guidelines for Ziprasidone injection:

Special dietary instructions for Ziprasidone Injection:

• Ziprasidone injection is typically administered by healthcare professionals in a clinical setting, so there may not be specific dietary restrictions associated with the injection itself.
• However, it’s important to follow a balanced and healthy diet as recommended by your healthcare provider to support your overall well-being.

What should I do if I forget a dose?

If you forget a dose of Ziprasidone Injection:

• Since Ziprasidone injection is typically administered by healthcare professionals, it is unlikely that you will be responsible for remembering the dose. The healthcare professionals will ensure the appropriate dosage schedule is followed.
• If you have any concerns about missed doses or the administration of the medication, it is best to consult with the healthcare professional overseeing your treatment.

What side effects can this medication cause?

Ziprasidone is an atypical antipsychotic medication that is available in oral and injectable formulations. Like any medication, it can cause side effects. Common side effects of ziprasidone injection may include:

• Injection site reactions: Pain, redness, swelling, or irritation at the site of injection.
• Dizziness: Feeling lightheaded or experiencing a spinning sensation.
• Sedation: Feeling drowsy or excessively sleepy.
• Nausea: An unpleasant sensation in the stomach that may lead to vomiting.
• Headache: Aching or discomfort in the head.
• Restlessness: Feeling agitated or unable to sit still.
• Insomnia: Difficulty falling asleep or staying asleep.
• Abnormal movements: Ziprasidone can rarely cause extrapyramidal symptoms, such as tremors, muscle stiffness, or uncontrollable movements.
• Changes in heart rate and rhythm: Ziprasidone can affect the electrical conduction system of the heart, potentially leading to a prolonged QT interval, which may increase the risk of a life-threatening arrhythmia called torsades de pointes.
• Low blood pressure: Ziprasidone may cause a drop in blood pressure, resulting in dizziness or lightheadedness.

It’s important to note that this is not an exhaustive list, and other side effects may occur. Additionally, individual responses to medication can vary, so not all individuals will experience the same side effects. It is recommended to consult a healthcare professional for more information about the specific side effects of ziprasidone injection and their management.

What should I know about storage and disposal of this medication?

Ziprasidone injection is a medication used to treat certain mental/mood disorders, such as schizophrenia and bipolar disorder. Here’s some important information regarding the storage, disposal, emergency/overdose situations, and other relevant details:

• Storage: Ziprasidone injection should be stored in its original packaging at room temperature, away from moisture and direct sunlight. Follow the specific storage instructions provided by the manufacturer or your healthcare provider.
• Disposal: Do not dispose of ziprasidone injection in household trash or pour it down the drain. Properly dispose of unused or expired medication through designated drug take-back programs or community disposal programs. If no such program is available, consult your pharmacist or healthcare provider for appropriate disposal methods.

In case of emergency/overdose

In case of an emergency or overdose, contact emergency medical services (such as 911) immediately. You can also contact your local poison control center at 1-800-222-1222 (United States) or your regional helpline number for guidance.

What other information should I know?

• • Ziprasidone injection should only be administered by a healthcare professional or under their direct supervision.
  • Inform your healthcare provider about any allergies or adverse reactions you may have to ziprasidone or any other medications.
  • Discuss your medical history, especially if you have a history of heart problems, low blood pressure, seizures, or any other relevant conditions.
  • Notify your healthcare provider about all the medications, supplements, or herbal products you are currently taking to avoid potential interactions.
  • Ziprasidone may cause drowsiness or dizziness, so avoid driving or operating heavy machinery until you know how it affects you.
  • It’s important to attend regular follow-up appointments with your healthcare provider to monitor your progress and any potential side effects.
  • Inform your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding, as the use of ziprasidone during pregnancy or breastfeeding may have risks.

Remember, this information is not exhaustive, and it’s essential to consult your healthcare provider or pharmacist for personalized advice and instructions regarding your specific situation and the use of ziprasidone injection.