Why is this medication prescribed?

Gefitinib is a medication that belongs to a class of drugs called tyrosine kinase inhibitors. It is primarily prescribed for the treatment of a specific type of lung cancer known as non-small cell lung cancer (NSCLC) that has certain genetic mutations.

Gefitinib is specifically used for patients with NSCLC who have mutations in the epidermal growth factor receptor (EGFR) gene. These mutations cause the cancer cells to grow and divide rapidly. Gefitinib works by blocking the activity of the EGFR protein, which helps to slow down or stop the growth of cancer cells.

How should this medicine be used?

When using Gefitinib, it is important to follow the instructions provided by your healthcare provider. Typically, it is taken orally in the form of tablets. The dosage and frequency of administration will be determined by your doctor based on various factors, including your overall health, the stage of your cancer, and your specific genetic mutation.

Gefitinib is usually taken once daily with or without food. It is important to swallow the tablet whole with a glass of water and not to crush or chew it. If you have difficulty swallowing tablets, you should consult your doctor or pharmacist for possible alternatives.

Other uses for this medicine

Gefitinib is primarily used for the treatment of non-small cell lung cancer (NSCLC) with specific EGFR mutations. However, it may also be prescribed off-label for other types of cancer or conditions. Off-label use means that the medication is being used for a purpose other than its approved indication. The decision to prescribe Gefitinib off-label is typically made by a healthcare provider based on their clinical judgment and the available evidence.

Some potential off-label uses of Gefitinib may include the treatment of other EGFR-mutated cancers, such as certain types of colorectal cancer or head and neck cancer. However, it’s important to note that the efficacy and safety of Gefitinib for these off-label uses may not have been extensively studied, and more research is needed to establish its effectiveness in these conditions.

What special precautions should I follow?

When taking Gefitinib, it is important to follow certain precautions:

• Inform your doctor about all medications you are currently taking, including prescription drugs, over-the-counter medications, and herbal supplements. Certain medications can interact with Gefitinib and affect its effectiveness or increase the risk of side effects.
• Notify your doctor if you have a history of liver disease, lung disease, or any other medical conditions, as Gefitinib may require dosage adjustments or careful monitoring in these cases.
• Discuss any known allergies you have, particularly to Gefitinib or any of its components.
• Women who are pregnant or planning to become pregnant should inform their healthcare provider, as Gefitinib may harm the unborn baby. Reliable contraception should be used during treatment and for a period of time after stopping the medication. It is also not recommended for breastfeeding women.
• Gefitinib can cause side effects such as diarrhea, skin rash, nausea, and changes in liver function. It is important to promptly report any side effects to your doctor and follow their guidance on managing them.
• Regular monitoring of liver function and other blood parameters may be required during treatment with Gefitinib.

Always consult with your healthcare provider for specific instructions and precautions based on your individual circumstances before starting Gefitinib or any other medication.

What special dietary instructions should I follow?

There are no specific dietary restrictions associated with Gefitinib. However, it is generally recommended to follow a healthy and balanced diet during cancer treatment to support overall well-being and maintain adequate nutrition. It is advisable to consult with a healthcare professional or a registered dietitian who specializes in oncology for personalized dietary recommendations.

What should I do if I forget a dose?

If you forget to take a dose of Gefitinib, it is important to follow these general guidelines:

• If it has been less than 12 hours since the missed dose, take the missed dose as soon as you remember. Then, continue with your regular dosing schedule.
• If it has been more than 12 hours since the missed dose, skip the missed dose and resume your medication at the next scheduled dose. Do not take a double dose to make up for the missed one.

It’s essential to adhere to the prescribed dosing schedule as closely as possible for the best outcomes. If you have any concerns or questions about missed doses or the dosing schedule, it is advisable to consult your healthcare provider or pharmacist for guidance.

What side effects can this medication cause?

Gefitinib can cause various side effects, and their severity and frequency may vary from person to person. It’s important to note that not all individuals will experience these side effects, and some side effects may be rare. Common side effects of Gefitinib may include:

• Skin rash: This is one of the most common side effects, typically appearing as a mild or moderate acne-like rash on the face, chest, back, or other parts of the body. It is important to inform your healthcare provider if you develop a rash, as they may recommend appropriate management strategies.
• Diarrhea: Gefitinib can cause an increase in bowel movements and loose stools. It is important to stay hydrated and inform your doctor if you experience persistent or severe diarrhea.
• Nausea and vomiting: Some individuals may experience nausea and vomiting while taking Gefitinib. Medications to manage these symptoms may be prescribed if needed.
• Fatigue: Feeling tired or fatigued is a common side effect. It is important to get enough rest and inform your healthcare provider if fatigue becomes severe or persists.
• Changes in liver function: Gefitinib may affect liver function, leading to elevated liver enzymes. Regular monitoring of liver function is typically recommended during treatment.
• Interstitial lung disease (ILD): Although rare, Gefitinib has been associated with the risk of ILD, which is a serious lung condition. Symptoms may include cough, difficulty breathing, and fever. It is important to seek immediate medical attention if you experience any new or worsening respiratory symptoms.
• Other side effects: Gefitinib may also cause other less common side effects, such as changes in appetite, weight loss, dry skin, nail changes, mouth sores, eye irritation, and elevated blood pressure.

What should I know about storage and disposal of this medication?

Gefitinib is a medication used in the treatment of certain types of lung cancer. Here’s what you should know about its storage, disposal, emergency procedures in case of overdose, and other relevant information:

• Storage of Gefitinib:
  • Store Gefitinib at room temperature, typically between 68°F and 77°F (20°C and 25°C).
  • Keep the medication in its original container, tightly closed, and away from moisture and direct sunlight.
  • Do not store Gefitinib in the bathroom or near the kitchen sink.
• Disposal of Gefitinib:
  • Follow your local regulations and guidelines for the proper disposal of medications.
  • If you are unsure about the disposal process, consult your healthcare provider or pharmacist.
  • Do not flush Gefitinib down the toilet or pour it into drains unless specifically instructed to do so.

In case of emergency/overdose

• In case of an overdose or emergency, immediately call your local emergency helpline (e.g., 911 in the United States) or seek medical assistance.
• If possible, provide the medical personnel with information such as the name of the medication (Gefitinib), dosage, and the time of the overdose.

What other information should I know?

1. • Take Gefitinib exactly as prescribed by your healthcare provider. Do not modify the dosage or stop taking it without consulting your doctor.
   • Inform your doctor about any other medications, vitamins, or herbal supplements you are taking, as they may interact with Gefitinib.
   • Gefitinib can cause side effects such as diarrhea, rash, nausea, or changes in liver function. Report any unusual or severe side effects to your healthcare provider.
   • If you miss a dose, take it as soon as you remember. However, if it is close to the time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule.
   • Keep Gefitinib out of reach of children and pets.

Remember, this information is a general guideline, and it’s essential to follow the specific instructions provided by your healthcare provider or the medication’s packaging. If you have any doubts or questions regarding Gefitinib or its usage, consult your doctor or pharmacist for personalized advice.