Why is this medication prescribed?

Gattex (teduglutide) is prescribed for the treatment of short bowel syndrome (SBS). SBS is a condition in which a significant portion of the small intestine is missing or non-functional, leading to malabsorption of nutrients and fluids. Gattex is a synthetic form of human glucagon-like peptide-2 (GLP-2), which is a hormone that helps in the growth and repair of the intestinal lining.

How should this medicine be used?

Gattex is used to reduce the dependence on parenteral nutrition (PN) in adults with SBS. PN is a method of providing nutrition directly into the bloodstream when the digestive system is unable to absorb nutrients adequately. Gattex stimulates the growth of the intestinal lining, increases the absorption of fluids and nutrients, and reduces the need for PN.

Gattex is typically used when other treatments for SBS, such as dietary modifications and medications, have not provided sufficient improvement. It is a prescription medication and should only be used under the guidance and supervision of a healthcare professional experienced in the treatment of SBS.

The specific dosing instructions for Gattex can vary depending on individual factors and should be determined by a healthcare professional. Generally, Gattex is injected subcutaneously (under the skin) once daily. The injection site should be rotated to different areas of the abdomen. Detailed instructions on proper administration techniques, including preparation and storage of the medication, should be provided by the prescribing doctor or pharmacist.

Other uses for this medicine

Gattex (teduglutide) is a medication primarily used for the treatment of short bowel syndrome (SBS), a condition characterized by the inability of the small intestine to adequately absorb nutrients and fluids. It works by stimulating the growth and function of the remaining intestine, reducing the dependence on parenteral nutrition (intravenous feeding).

Aside from its primary use in SBS, Gattex is not typically prescribed for other conditions. However, it’s important to consult with a healthcare professional for personalized advice regarding the use of any medication.

What special precautions should I follow?

Regarding precautions, it’s crucial to follow your healthcare provider’s instructions and adhere to the prescribed dosage. Here are some general precautions to consider:

• Medical supervision: Gattex should be prescribed and monitored by a healthcare professional experienced in managing patients with short bowel syndrome or other related conditions.
• Allergies: Inform your doctor about any known allergies or adverse reactions to teduglutide or any other medications.
• Pregnancy and breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss the potential risks and benefits of Gattex with your healthcare provider. The effects of Gattex on unborn babies or infants through breast milk are not well-studied.
• Medication interactions: Inform your doctor about all the medications, supplements, and herbal products you are currently taking to avoid any potential interactions.
• Side effects: Be aware of the possible side effects of Gattex, which may include gastrointestinal discomfort, injection site reactions, nausea, abdominal pain, vomiting, and headaches. Report any persistent or severe side effects to your healthcare provider.
• Monitoring and testing: Regular monitoring of nutritional status, fluid balance, and liver function may be necessary while taking Gattex.
• Injection technique: If Gattex is administered via injection, make sure to follow proper injection techniques and instructions provided by your healthcare professional.
• Storage and disposal: Store Gattex as directed, and properly dispose of any unused or expired medication in accordance with local regulations.

What special dietary instructions should I follow?

When taking Gattex (teduglutide), there are no specific dietary restrictions that need to be followed. However, it is important to maintain a well-balanced and nutritious diet as recommended by your healthcare provider. Since Gattex is prescribed for short bowel syndrome (SBS), it’s crucial to ensure adequate nutritional intake to support your overall health.

What should I do if I forget a dose?

• If you forget a dose and it has been less than 48 hours since your last dose, take the missed dose as soon as you remember. Continue with your regular dosing schedule afterward.
• If it has been more than 48 hours since your last dose, skip the missed dose and continue with the next scheduled dose. Do not take a double dose to make up for the missed one.
• It’s important to maintain regular dosing intervals to ensure the desired therapeutic effects. If you frequently forget doses, consider setting reminders or alarms to help you remember.

What side effects can this medication cause?

Gattex (teduglutide) may cause several side effects. It’s important to note that not everyone experiences these side effects, and their severity can vary from person to person. Common side effects of Gattex include:

• Gastrointestinal discomfort: This may include symptoms such as abdominal pain, bloating, indigestion, and flatulence.
• Injection site reactions: Gattex is typically administered via subcutaneous injection, and some individuals may experience redness, swelling, itching, or pain at the injection site.
• Nausea and vomiting: These symptoms can occur, especially when initiating treatment, but usually improve with time.
• Headache: Some individuals may experience headaches while taking Gattex.
• Abdominal distension: This refers to a feeling of fullness or swelling in the abdomen.
• Fluid overload: In some cases, Gattex may cause an excessive fluid build-up, resulting in swelling of the extremities or shortness of breath. This is more likely to occur if the dosage is not adjusted properly.

Less common but more serious side effects of Gattex may include:

• Intestinal obstruction: Gattex can increase the risk of intestinal blockage or obstruction. Seek medical attention immediately if you experience severe abdominal pain, bloating, or changes in bowel movements.
• Gallbladder disease: Gattex may increase the risk of developing gallbladder disease, such as gallstones. Symptoms may include abdominal pain, nausea, vomiting, or jaundice (yellowing of the skin or eyes).
• Pancreatitis: In rare cases, Gattex may cause inflammation of the pancreas, leading to severe abdominal pain, nausea, and vomiting.

It’s important to report any persistent or severe side effects to your healthcare provider. They can evaluate your symptoms and provide appropriate guidance or adjust your treatment if necessary.

What should I know about storage and disposal of this medication?

• Gattex (teduglutide) is a medication used to treat Short Bowel Syndrome (SBS) in adults who are dependent on parenteral nutrition. It helps improve intestinal absorption and reduce the need for intravenous nutrition. Here are some important points to know about the storage, disposal, and emergency/overdose procedures for Gattex:Storage:
  • Gattex should be stored in the refrigerator between 36°F and 46°F (2°C and 8°C).
  • Do not freeze Gattex or expose it to temperatures above 86°F (30°C).
  • Keep the Gattex vials in the original carton to protect them from light.

  Disposal:

  • Unused or expired Gattex should be disposed of properly.
  • Do not flush Gattex down the toilet or pour it down the drain unless instructed to do so by your healthcare provider or local waste disposal guidelines.
  • Contact your healthcare provider or a local waste disposal company to learn about the proper disposal methods in your area.

In case of emergency/overdose

• In case of an emergency or overdose, immediately call your local emergency services or go to the nearest emergency room.
• It is important to have the Gattex package or label available to provide necessary information to healthcare professionals in case of an emergency.
• If possible, inform the healthcare professionals about the exact amount of Gattex ingested and the time of ingestion.

What other information should I know?

• Gattex is a prescription medication and should only be used under the guidance of a healthcare professional.
• Inform your healthcare provider about any existing medical conditions or allergies before starting Gattex.
• Keep all appointments with your healthcare provider for regular check-ups and monitoring while using Gattex.
• Report any side effects or concerns to your healthcare provider promptly.
• Do not change the dosage or stop using Gattex without consulting your healthcare provider.

It’s essential to consult with your healthcare provider or pharmacist for specific instructions and any additional information regarding the storage, disposal, and emergency procedures for Gattex, as they can provide personalized guidance based on your individual circumstances.