Why is this medication prescribed?

Fusilev (levoleucovorin) is a medication used in combination with other chemotherapy drugs to treat certain types of cancer. It is primarily prescribed to help reduce the toxic effects of methotrexate, a chemotherapy drug, and to increase the effectiveness of other chemotherapy agents.

Here are some specific reasons why Fusilev may be prescribed:

• To counteract the toxic effects of methotrexate: Methotrexate is commonly used in the treatment of various cancers, including breast cancer, lung cancer, and certain types of leukemia. However, it can cause serious side effects, particularly when given in high doses. Fusilev is often used to “rescue” patients from the toxic effects of methotrexate by providing a form of folate that helps protect healthy cells.
• To enhance the effectiveness of chemotherapy: Fusilev can also increase the effectiveness of other chemotherapy drugs when used in combination. By providing an active form of folate, it helps support the production of DNA and RNA, which is essential for the growth and division of cancer cells. This can improve the overall response to chemotherapy treatment.

How should this medicine be used?

Fusilev (levoleucovorin) is typically administered intravenously (IV) by a healthcare professional in a clinical setting, such as a hospital or infusion center. Here’s a general guideline on how Fusilev is commonly used:

• Dosage: The dosage of Fusilev depends on several factors, including the type of cancer being treated, the other chemotherapy drugs being used, and the patient’s individual medical history and response to treatment. Your healthcare provider will determine the appropriate dosage for you.
• Frequency of Administration: Fusilev is usually given either once daily or once every few days, depending on the specific treatment regimen prescribed by your healthcare provider.
• Administration: Fusilev is administered intravenously (IV) over a period of time, typically ranging from a few minutes to several hours, depending on the dosage and infusion rate. The infusion is usually done through a vein in your arm or hand.
• Precautions: Before administering Fusilev, your healthcare provider will check your blood counts and liver function to ensure it is safe to proceed with treatment. They will also monitor you closely during and after the infusion for any signs of allergic reactions or other adverse effects.
• Duration of Treatment: The duration of treatment with Fusilev will vary depending on the specific cancer being treated and the overall treatment plan developed by your healthcare provider. Treatment may consist of multiple cycles of chemotherapy, with Fusilev being administered during each cycle.
• Follow-Up: It’s essential to attend all scheduled treatment appointments and follow-up visits with your healthcare provider during and after treatment with Fusilev. They will monitor your progress, assess your response to treatment, and make any necessary adjustments to your treatment plan.

Always follow the instructions provided by your healthcare provider regarding the use of Fusilev, including dosage, frequency of administration, and any special precautions or instructions. If you have any questions or concerns about how Fusilev is being used or its potential side effects, be sure to discuss them with your healthcare provider.

Other uses for this medicine

Some potential off-label uses of Fusilev include:

• Treatment of Methotrexate Overdose: Fusilev may be used as part of the treatment for methotrexate overdose or toxicity. By providing a source of active folate, it can help counteract the toxic effects of methotrexate and reduce the risk of severe complications.
• Supportive Therapy for Certain Autoimmune Diseases: Fusilev may be used as adjunctive therapy in the treatment of certain autoimmune diseases, such as rheumatoid arthritis or psoriasis, especially when methotrexate is used as a disease-modifying anti-rheumatic drug (DMARD). Similar to its role in cancer treatment, Fusilev can help reduce the toxicity of methotrexate in these conditions.

What special precautions should I follow?

Regarding special precautions to follow for Fusilev, here are some important considerations:

• Allergy: Inform your healthcare provider if you have a known allergy to levoleucovorin, folic acid, or any other ingredients in Fusilev. Allergic reactions to Fusilev are rare but can occur.
• Medical Conditions: Inform your healthcare provider about any pre-existing medical conditions you have, especially conditions affecting the liver, kidneys, or bone marrow. Fusilev may require dosage adjustments or special monitoring in patients with certain medical conditions.
• Pregnancy and Breastfeeding: Inform your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding. The safety of Fusilev during pregnancy and breastfeeding has not been established, so the potential risks and benefits should be carefully considered.
• Interactions: Inform your healthcare provider about all other medications, supplements, or herbal products you are taking, as they may interact with Fusilev. This includes both prescription and over-the-counter medications.
• Monitoring: Your healthcare provider will monitor your blood counts, liver function, and kidney function regularly during treatment with Fusilev to detect any potential side effects or adverse reactions.
• Administration: Fusilev is typically administered intravenously by a healthcare professional in a clinical setting. It’s essential to follow the dosage instructions provided by your healthcare provider and to attend all scheduled treatment appointments.

Always follow your healthcare provider’s instructions and guidance regarding the use of Fusilev, including any special precautions or considerations specific to your individual circumstances.

What special dietary instructions should I follow?

Regarding special dietary instructions for Fusilev, there are no specific dietary restrictions associated with its use. However, maintaining a healthy and balanced diet is generally recommended during cancer treatment to support overall health and well-being.

What should I do if I forget a dose?

If you forget a dose of Fusilev, contact your healthcare provider or medical team for guidance. They can advise you on whether the missed dose needs to be rescheduled or if any adjustments to your treatment plan are necessary. It’s important not to double up on doses unless instructed to do so by your healthcare provider.

What side effects can this medication cause?

Fusilev (levoleucovorin) is generally well-tolerated, but like any medication, it can cause side effects. Common side effects of Fusilev may include:

• Nausea and vomiting: These are common side effects of many chemotherapy drugs, including Fusilev. Your healthcare provider may prescribe anti-nausea medications to help manage these symptoms.
• Diarrhea or constipation: Changes in bowel habits, including diarrhea or constipation, may occur with Fusilev treatment. It’s essential to stay hydrated and maintain a healthy diet to help manage these symptoms.
• Mouth sores: Fusilev may cause mouth sores or mucositis (inflammation of the mucous membranes in the mouth and throat). Maintaining good oral hygiene and using mouthwash as recommended by your healthcare provider can help alleviate this side effect.
• Fatigue: Feeling tired or fatigued is a common side effect of chemotherapy, including Fusilev. It’s essential to get plenty of rest and conserve energy during treatment.
• Low blood cell counts: Fusilev can cause a decrease in certain blood cell counts, including white blood cells, red blood cells, and platelets. This may increase the risk of infections, anemia, and bleeding. Your healthcare provider will monitor your blood counts regularly during treatment.
• Allergic reactions: Although rare, allergic reactions to Fusilev can occur. Seek medical attention immediately if you experience symptoms such as rash, itching, swelling, difficulty breathing, or dizziness.
• Liver toxicity: Fusilev may cause liver toxicity, resulting in elevated liver enzymes. Your healthcare provider will monitor your liver function regularly during treatment.
• Kidney toxicity: In some cases, Fusilev may cause kidney toxicity, resulting in changes in kidney function or kidney damage. Your healthcare provider will monitor your kidney function regularly during treatment.

It’s essential to communicate any side effects or concerns you may have with your healthcare provider during Fusilev treatment. They can provide guidance on managing side effects and may adjust your treatment plan if necessary to minimize discomfort and maximize the effectiveness of the medication.

What should I know about storage and disposal of this medication?

Storage and disposal of Fusilev:

• Storage: Fusilev should be stored at room temperature, away from moisture and heat. Avoid freezing the medication. Keep it out of reach of children and pets.
• Disposal: Dispose of any unused Fusilev according to local regulations or guidelines provided by your healthcare provider or pharmacist. Do not flush medications down the toilet or pour them down the drain unless instructed to do so.

In case of emergency/overdose

In case of emergency or overdose, seek immediate medical attention or contact a poison control center (such as the Poison Help hotline in the United States at 1-800-222-1222). Overdose symptoms may include severe nausea, vomiting, diarrhea, mouth sores, and changes in blood cell counts.

What other information should I know?

• Follow all instructions provided by your healthcare provider or pharmacist regarding the administration of Fusilev.
• Inform your healthcare provider about any other medications, supplements, or herbal products you are taking, as they may interact with Fusilev.
• Attend all scheduled appointments for blood tests and monitoring of your condition during Fusilev treatment.
• Report any new or worsening symptoms to your healthcare provider promptly.
• Discuss any concerns or questions you have about Fusilev with your healthcare provider or pharmacist.
• Keep a list of all medications you are taking, including Fusilev, and share it with your healthcare provider and pharmacist.

Overall, it’s crucial to store Fusilev properly, dispose of it safely, seek medical attention in case of emergency or overdose, and stay informed about its use and potential side effects. Always follow the instructions provided by your healthcare provider for the safest and most effective treatment.