WARNING

Ferriprox (deferiprone) is a medication used to treat iron overload in people who receive regular blood transfusions, such as those with thalassemia or other types of anemia. While it can be effective, there are several risks associated with taking Ferriprox:

• Neutropenia: This is a condition where the number of white blood cells called neutrophils is abnormally low, increasing the risk of infections.
• Agranulocytosis: This is a severe drop in white blood cells, which can lead to a weakened immune system and increase the risk of severe infections.
• Hepatotoxicity: Ferriprox can cause liver damage, including elevated liver enzymes and hepatitis.
• Gastrointestinal Symptoms: Common side effects include nausea, vomiting, and abdominal pain.
• Joint Pain: Some individuals may experience joint pain or inflammation while taking Ferriprox.
• Neurological Effects: In rare cases, Ferriprox has been associated with neurological side effects such as neuropathy and ataxia (loss of coordination).
• Ocular Effects: There have been reports of changes in visual acuity and color vision while taking Ferriprox.
• Bone Marrow Suppression: Ferriprox can suppress bone marrow function, which may lead to anemia, thrombocytopenia (low platelet count), or leukopenia (low white blood cell count).

It’s important for individuals taking Ferriprox to be closely monitored by their healthcare provider for signs of these potential side effects. Additionally, regular blood tests are typically conducted to monitor blood cell counts, liver function, and other parameters.

Why is this medication prescribed?

Ferriprox (deferiprone) is prescribed primarily for the treatment of iron overload in individuals who receive regular blood transfusions, typically due to conditions such as thalassemia or other types of anemia. Iron overload can occur when the body accumulates excess iron from repeated transfusions, leading to organ damage and other complications.

Ferriprox works by binding to excess iron in the body and helping to remove it through urine excretion. By reducing iron levels, Ferriprox helps prevent organ damage and other complications associated with iron overload.

How should this medicine be used?

Ferriprox is usually taken orally in the form of tablets or oral solution. The dosage and frequency of administration may vary depending on factors such as the individual’s age, weight, and the severity of iron overload. It’s important to follow the dosage instructions provided by a healthcare provider or pharmacist.

Typically, Ferriprox is taken on an empty stomach, at least one hour before or two hours after meals. This helps maximize its absorption in the body. It’s important not to crush or chew Ferriprox tablets, as this can affect its effectiveness.

Patients should continue taking Ferriprox as prescribed by their healthcare provider, even if they start to feel better. Stopping the medication abruptly can lead to a rapid increase in iron levels, which can be dangerous.

Regular monitoring by a healthcare provider is essential while taking Ferriprox to assess its effectiveness and monitor for any potential side effects or complications. This may include blood tests to check iron levels, liver function, and blood cell counts. Any concerns or side effects should be reported to a healthcare provider promptly.

Other uses for this medicine

While Ferriprox (deferiprone) is primarily used for the treatment of iron overload in individuals who receive regular blood transfusions, it has also been investigated for potential use in other conditions. Some research suggests that Ferriprox may have therapeutic potential in diseases such as Friedreich’s ataxia, neurodegenerative disorders associated with iron accumulation, and certain cancers. However, these uses are still under investigation, and Ferriprox is not currently approved for these indications.

What special precautions should I follow?

When taking Ferriprox, there are several special precautions to keep in mind:

• Regular Monitoring: Patients should undergo regular monitoring by their healthcare provider while taking Ferriprox. This includes periodic blood tests to assess iron levels, liver function, and blood cell counts.
• Avoid Alcohol: Alcohol consumption should be limited or avoided while taking Ferriprox, as it may increase the risk of liver toxicity.
• Pregnancy and Breastfeeding: It’s important to inform your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding, as the safety of Ferriprox during pregnancy and breastfeeding has not been established.
• Neutropenia and Infections: Ferriprox can cause neutropenia, a condition characterized by a low white blood cell count, which increases the risk of infections. Patients should be vigilant for signs of infection and report any symptoms to their healthcare provider promptly.
• Liver Function: Patients with pre-existing liver disease or elevated liver enzymes may require close monitoring while taking Ferriprox.
• Vision Changes: Some individuals may experience changes in visual acuity or color vision while taking Ferriprox. Any changes in vision should be reported to a healthcare provider.
• Joint Pain: Patients should be aware of the potential for joint pain or inflammation while taking Ferriprox and report any symptoms to their healthcare provider.
• Medication Interactions: Patients should inform their healthcare provider of all medications, supplements, and herbal products they are taking, as Ferriprox may interact with certain medications.

It’s essential to follow your healthcare provider’s instructions and advice while taking Ferriprox and to report any concerns or side effects promptly.

What special dietary instructions should I follow?

Regarding special dietary instructions for Ferriprox, it’s generally recommended to take the medication on an empty stomach, at least one hour before or two hours after meals. This can help maximize its absorption. Avoid consuming foods or drinks that may interfere with the absorption of Ferriprox, such as dairy products or calcium-rich foods, around the time you take your dose.

What should I do if I forget a dose?

If you forget to take a dose of Ferriprox, take it as soon as you remember, unless it’s almost time for your next scheduled dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you’re unsure about what to do, consult your healthcare provider or pharmacist for guidance.

What side effects can this medication cause?

Ferriprox (deferiprone) can cause various side effects, although not everyone experiences them. Common side effects include:

• Gastrointestinal Symptoms: Nausea, vomiting, abdominal pain, and diarrhea are common side effects of Ferriprox.
• Joint Pain: Some individuals may experience joint pain or inflammation while taking Ferriprox.
• Neutropenia: This is a condition where the number of white blood cells called neutrophils is abnormally low, increasing the risk of infections.
• Agranulocytosis: A severe drop in white blood cell count, which can lead to a weakened immune system and increase the risk of severe infections.
• Hepatotoxicity: Ferriprox can cause liver damage, including elevated liver enzymes and hepatitis.
• Neurological Effects: In rare cases, Ferriprox has been associated with neurological side effects such as neuropathy (nerve damage) and ataxia (loss of coordination).
• Ocular Effects: Changes in visual acuity and color vision have been reported in some individuals taking Ferriprox.
• Bone Marrow Suppression: Ferriprox can suppress bone marrow function, leading to anemia, thrombocytopenia (low platelet count), or leukopenia (low white blood cell count).

It’s essential for individuals taking Ferriprox to be aware of these potential side effects and to report any concerns or symptoms to their healthcare provider promptly. In some cases, dose adjustments or discontinuation of the medication may be necessary to manage side effects effectively.

What should I know about storage and disposal of this medication?

Storage and disposal:

• Storage: Store Ferriprox tablets or oral solution at room temperature away from light and moisture. Keep it out of reach of children and pets.
• Disposal: Dispose of any unused or expired Ferriprox medication properly according to local regulations. Do not flush it down the toilet or pour it down the drain unless instructed to do so. Consult your healthcare provider or pharmacist for guidance on proper disposal methods.

In case of emergency/overdose

If you suspect an overdose of Ferriprox or experience severe symptoms such as difficulty breathing, fainting, or seizures, seek immediate medical attention or call your local poison control center. It’s important to take the medication container or packaging with you to the hospital to help healthcare providers determine the appropriate treatment.

What other information should I know?

• Inform your healthcare provider about all medications, supplements, and herbal products you are taking before starting Ferriprox to avoid potential interactions.
• Attend all scheduled appointments with your healthcare provider for monitoring of iron levels, liver function, and blood cell counts.
• Do not change your dose or stop taking Ferriprox without consulting your healthcare provider.
• Follow dietary instructions provided by your healthcare provider, such as taking Ferriprox on an empty stomach to maximize absorption.
• Report any side effects or concerns to your healthcare provider promptly.
• Keep Ferriprox medication out of reach of children and pets.
• If you have any questions or concerns about Ferriprox, talk to your healthcare provider or pharmacist for guidance.

By following these guidelines, you can ensure the safe and effective use of Ferriprox and minimize the risk of complications.