Why is this medication prescribed?

Fasenra (benralizumab) is a medication primarily prescribed for the treatment of severe eosinophilic asthma, which is a type of asthma characterized by high levels of eosinophils, a type of white blood cell, in the blood and airways. It is not intended for the relief of acute asthma symptoms but rather as a maintenance treatment to reduce the frequency of asthma exacerbations.

Fasenra works by binding to the alpha subunit of the interleukin-5 receptor on eosinophils and inducing apoptosis (cell death) of these cells. By reducing the number of eosinophils, Fasenra helps to decrease inflammation in the airways and improve asthma control.

How should this medicine be used?

Fasenra (benralizumab) is a prescription medication used to treat severe eosinophilic asthma. It is typically administered as a subcutaneous injection (under the skin) by a healthcare professional. Here’s how Fasenra is usually used:

• Dosage: The recommended dose of Fasenra is 30 mg administered once every 4 weeks for the first 3 doses, and then once every 8 weeks thereafter. Your healthcare provider will determine the appropriate dosage for you based on your individual circumstances.
• Administration: Fasenra is administered via a prefilled syringe or prefilled autoinjector. Your healthcare provider will show you how to properly inject the medication or may administer it for you.
• Injection Site: Fasenra is injected into the thigh or abdomen. Your healthcare provider will advise you on rotating injection sites to reduce the risk of injection site reactions.
• Preparation: Before administering Fasenra, make sure to check the expiration date and visually inspect the solution for particulate matter or discoloration. Do not use the medication if it appears cloudy or contains particles.
• Storage: Fasenra should be stored in the refrigerator at 2°C to 8°C (36°F to 46°F). Do not freeze. If necessary, Fasenra can be kept at room temperature (up to 25°C or 77°F) for a single period of up to 14 days. Once removed from the refrigerator, Fasenra should be used within 14 days or discarded.
• Follow-up: Your healthcare provider will monitor your progress and may adjust your treatment regimen as needed.

Always follow your healthcare provider’s instructions and read the patient information leaflet provided with the medication for detailed instructions on proper use and administration. If you have any questions or concerns about using Fasenra, don’t hesitate to consult your healthcare provider.

Other uses for this medicine

Fasenra (benralizumab) is primarily indicated for the treatment of severe eosinophilic asthma in patients aged 12 years and older. However, it may have other potential uses or applications, which would be determined by your healthcare provider based on your specific medical condition. Some off-label uses or investigational uses of Fasenra may include other eosinophilic conditions or certain types of chronic obstructive pulmonary disease (COPD), but these uses would need to be discussed with your healthcare provider and considered on a case-by-case basis.

What special precautions should I follow?

Regarding special precautions for Fasenra, here are some important points to consider:

• Allergic Reactions: Some individuals may experience allergic reactions to Fasenra, including rash, itching, swelling of the face, lips, tongue, or throat, and difficulty breathing. If you experience any of these symptoms after receiving Fasenra, seek medical attention immediately.
• Parasitic Infections: Fasenra works by targeting and depleting eosinophils, which are a type of white blood cell involved in allergic inflammation. However, eosinophils also play a role in defending against parasitic infections. Therefore, patients with a history of parasitic infections should be monitored closely during treatment with Fasenra.
• Respiratory Infections: Patients receiving Fasenra may be at an increased risk of respiratory infections, including viral respiratory tract infections. If you develop symptoms of a respiratory infection, such as cough, fever, or difficulty breathing, contact your healthcare provider.
• Immunizations: It is recommended to bring up-to-date on all immunizations before starting treatment with Fasenra, as it may affect your body’s immune response to certain vaccines. Discuss with your healthcare provider which vaccines are appropriate for you.
• Pregnancy and Breastfeeding: The safety of Fasenra during pregnancy and breastfeeding has not been established. Consult your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding before starting treatment with Fasenra.
• Other Medications: Inform your healthcare provider about all medications, supplements, and herbal products you are taking, as they may interact with Fasenra.

Always follow your healthcare provider’s instructions and discuss any questions or concerns you may have about Fasenra or its use. They can provide personalized guidance based on your medical history and individual circumstances.

What special dietary instructions should I follow?

There are no specific dietary instructions associated with Fasenra. However, maintaining a healthy and balanced diet is generally recommended for overall health and may support your treatment regimen.

What should I do if I forget a dose?

If you miss a dose of Fasenra, contact your healthcare provider as soon as possible to discuss the best course of action. Depending on how far past the missed dose you are, your healthcare provider may recommend rescheduling the dose or providing further guidance. It’s important not to double up on doses to make up for a missed one without consulting your healthcare provider first.

What side effects can this medication cause?

Fasenra (benralizumab) may cause side effects in some individuals. It’s important to be aware of these potential side effects and discuss any concerns with your healthcare provider. Common side effects of Fasenra may include:

• Injection Site Reactions: Pain, redness, itching, or swelling at the injection site are common side effects of Fasenra.
• Headache: Some individuals may experience headaches after receiving Fasenra.
• Sore Throat: Fasenra may cause throat irritation or sore throat.
• Fatigue: Feeling tired or fatigued is a potential side effect of Fasenra.
• Muscle Pain: Some individuals may experience muscle pain or discomfort.
• Nasopharyngitis: This refers to inflammation of the nose and throat, which may cause symptoms such as a runny or stuffy nose, sneezing, or sore throat.
• Upper Respiratory Tract Infections: Fasenra may increase the risk of upper respiratory tract infections, such as the common cold.
• Hypersensitivity Reactions: In rare cases, Fasenra may cause serious allergic reactions, including anaphylaxis. Symptoms may include rash, itching, swelling of the face, lips, tongue, or throat, difficulty breathing, or chest tightness. Seek immediate medical attention if you experience any signs of a severe allergic reaction.
• Parasitic Infections: Depletion of eosinophils by Fasenra may increase the risk of parasitic infections in some individuals.
• Elevated Liver Enzymes: Some patients may experience elevated levels of liver enzymes, which can be detected through blood tests.

It’s essential to report any side effects to your healthcare provider, even if they seem mild. Your healthcare provider can provide guidance on managing side effects and may adjust your treatment regimen if necessary. Additionally, if you experience any signs of a severe allergic reaction or other serious side effects, seek immediate medical attention.

What should I know about storage and disposal of this medication?

Storage and Disposal:

• Storage: Fasenra should be stored in the refrigerator at a temperature between 2°C to 8°C (36°F to 46°F). Do not freeze. Keep Fasenra in its original carton to protect it from light. If necessary, it can be stored at room temperature (up to 25°C or 77°F) for a single period of up to 14 days. Once removed from the refrigerator, Fasenra should be used within 14 days or discarded.
• Disposal: Dispose of used needles and syringes in a puncture-resistant container. Do not dispose of needles or syringes in the household trash. Follow local regulations or ask your healthcare provider for guidance on proper disposal.

In case of emergency/overdose

In the case of an emergency or overdose of Fasenra, contact your healthcare provider, local poison control center, or emergency room immediately. Symptoms of an overdose may include an increase in side effects such as headache, muscle pain, sore throat, or respiratory symptoms. Do not attempt to manage an overdose without professional medical guidance.

What other information should I know?

• Follow-Up: Attend all scheduled appointments with your healthcare provider for follow-up evaluations and monitoring of your condition.
• Immunizations: Inform your healthcare provider that you are receiving treatment with Fasenra, as it may affect your immune response to certain vaccines. Discuss which vaccinations are appropriate for you.
• Medical Alert: Wear a medical alert bracelet or carry a medical alert card to inform healthcare providers about your treatment with Fasenra in case of emergency situations.
• Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss the risks and benefits of Fasenra with your healthcare provider. The safety of Fasenra during pregnancy and breastfeeding has not been established.
• Travel: If you need to travel with Fasenra, ensure proper storage and transportation according to the manufacturer’s recommendations. Carry necessary supplies and documentation, such as a prescription and medical alert information, when traveling.
• Storage and Handling: Keep Fasenra out of the reach of children and pets. Store it in a secure location to prevent accidental ingestion or misuse.

Always follow your healthcare provider’s instructions and consult them if you have any questions or concerns about the storage, disposal, emergency procedures, or other aspects of Fasenra treatment.