WARNING

Farydak (panobinostat) is a medication used in the treatment of multiple myeloma, a type of blood cancer. Like all medications, Farydak carries potential risks and side effects. Some of the risks associated with taking Farydak include:

• Cardiovascular Effects: Farydak may increase the risk of heart problems, including heart rhythm abnormalities and heart failure. Patients with a history of heart disease should be closely monitored.
• Gastrointestinal Issues: Common side effects of Farydak include nausea, diarrhea, vomiting, and decreased appetite. These symptoms can sometimes be severe and may require treatment or adjustment of the medication dosage.
• Bleeding: Farydak can increase the risk of bleeding, including gastrointestinal bleeding and hemorrhage. Patients should be monitored for signs of bleeding and precautions should be taken in individuals at increased risk.
• Liver Toxicity: Farydak can cause liver damage, leading to elevated liver enzymes and potentially liver failure. Regular liver function tests are typically recommended during treatment.
• Fatigue: Many patients experience fatigue while taking Farydak, which can affect daily functioning and quality of life.
• Infections: Farydak may suppress the immune system, increasing the risk of infections. Patients should be vigilant for signs of infection and may require prophylactic antibiotics or antiviral medications.
• Blood Disorders: Farydak can cause low blood cell counts, including low white blood cell counts (neutropenia), low platelet counts (thrombocytopenia), and low red blood cell counts (anemia). These can increase the risk of infection, bleeding, and fatigue.
• Drug Interactions: Farydak can interact with other medications, potentially affecting their effectiveness or increasing the risk of side effects. Patients should inform their healthcare provider of all medications they are taking.
• Skin Reactions: Some patients may experience skin reactions such as rash or pruritus (itching) while taking Farydak.
• Tumor Lysis Syndrome: In some cases, Farydak can cause tumor lysis syndrome, a condition characterized by the rapid breakdown of cancer cells, leading to metabolic abnormalities and organ damage.

It’s essential for patients taking Farydak to discuss these risks with their healthcare provider and report any concerning symptoms promptly for proper management. Additionally, close monitoring and regular follow-up appointments are typically recommended to monitor for potential side effects and adjust treatment as needed.

Why is this medication prescribed?

Farydak (panobinostat) is prescribed primarily for the treatment of multiple myeloma, a type of blood cancer. It is typically used in combination with other medications, such as bortezomib and dexamethasone, in patients who have received at least two prior therapies, including bortezomib and an immunomodulatory agent.

The main goal of Farydak treatment is to inhibit the growth and spread of cancer cells, thereby slowing down the progression of multiple myeloma and potentially extending patients’ lives.

Farydak is a type of medication known as a histone deacetylase (HDAC) inhibitor. It works by interfering with certain enzymes in cancer cells, which can disrupt their growth and survival mechanisms.

How should this medicine be used?

Here are some key points on how Farydak should be used:

• Dosage: The dosage of Farydak can vary based on individual factors such as the patient’s weight, overall health, and other medications they may be taking. It is typically taken orally in capsule form.
• Treatment Schedule: Farydak is usually taken in cycles, with the specific dosing schedule determined by the healthcare provider. Each treatment cycle may consist of several days of taking Farydak followed by a rest period.
• Combination Therapy: Farydak is often used in combination with other medications, such as bortezomib and dexamethasone. The healthcare provider will determine the most appropriate combination therapy based on the individual patient’s condition and treatment history.
• Monitoring: During treatment with Farydak, patients will typically undergo regular monitoring, including blood tests to assess their blood cell counts and liver function. This helps to monitor for potential side effects and adjust treatment as needed.
• Adherence: It’s essential for patients to take Farydak exactly as prescribed by their healthcare provider. Missing doses or taking the medication incorrectly can affect its effectiveness and increase the risk of side effects.
• Side Effect Management: Patients should communicate any side effects or concerns with their healthcare provider promptly. Some side effects, such as nausea, diarrhea, or fatigue, can often be managed with supportive care or adjustments to the treatment regimen.

Overall, Farydak is a valuable medication in the treatment of multiple myeloma, but its use requires close monitoring and careful management to optimize effectiveness and minimize risks.

Other uses for this medicine

• Farydak is primarily used in combination with other medications, such as bortezomib and dexamethasone, for the treatment of multiple myeloma that has relapsed or has not responded to previous treatments.
• Research into the potential use of Farydak for other types of cancer or medical conditions may be ongoing, but its use is currently approved only for multiple myeloma.

What special precautions should I follow?

As for special precautions to follow when taking Farydak:

• Cardiac Monitoring: Due to the potential for cardiovascular effects, including heart rhythm abnormalities and heart failure, your healthcare provider may monitor your heart function regularly, especially if you have a history of heart disease.
• Liver Function Monitoring: Regular liver function tests are typically conducted during Farydak treatment to monitor for signs of liver toxicity. If you have pre-existing liver conditions, your healthcare provider may adjust your treatment regimen accordingly.
• Blood Cell Counts: Farydak can lower blood cell counts, including white blood cells, red blood cells, and platelets. Your healthcare provider will monitor these levels regularly to assess your risk of infection, anemia, or bleeding.
• Infection Risk: Due to the potential suppression of the immune system, you should take precautions to minimize the risk of infection. This includes practicing good hygiene, avoiding close contact with sick individuals, and promptly reporting any signs of infection to your healthcare provider.
• Pregnancy and Contraception: Farydak can harm an unborn baby, so it’s crucial to use effective contraception during treatment and for at least 3 months after the last dose. If you become pregnant or plan to become pregnant while taking Farydak, notify your healthcare provider immediately.
• Food Interactions: Farydak should be taken with food to help reduce gastrointestinal side effects. Your healthcare provider may recommend specific types of food or meals to consume with each dose.
• Grapefruit Warning: Avoid consuming grapefruit or grapefruit juice while taking Farydak, as it can increase the risk of side effects or alter the medication’s effectiveness.

Always follow your healthcare provider’s instructions and recommendations regarding the use of Farydak, and communicate any concerns or side effects promptly.

What special dietary instructions should I follow?

Special Dietary Instructions:

• Food Interactions: Farydak should be taken with food to help reduce gastrointestinal side effects. Your healthcare provider may recommend specific types of food or meals to consume with each dose.
• Grapefruit Warning: Avoid consuming grapefruit or grapefruit juice while taking Farydak, as it can increase the risk of side effects or alter the medication’s effectiveness.

What should I do if I forget a dose?

If you forget to take a dose of Farydak at your scheduled time, take it as soon as you remember, unless it’s within 12 hours of your next dose. In that case, skip the missed dose and take your next dose at the regular time. Do not double the dose to make up for a missed one. It’s essential to communicate any missed doses or concerns with your healthcare provider, who can provide guidance on how to proceed.

What side effects can this medication cause?

Farydak (panobinostat), like many medications, can cause various side effects. It’s essential to be aware of these potential side effects and communicate with your healthcare provider if you experience any of them. Common side effects of Farydak may include:

• Gastrointestinal Issues: Nausea, vomiting, diarrhea, and loss of appetite are common side effects of Farydak. These symptoms can sometimes be severe and may require supportive care or adjustments to the treatment regimen.
• Fatigue: Many patients experience fatigue or weakness while taking Farydak, which can affect daily activities and quality of life.
• Hematologic Effects: Farydak can cause changes in blood cell counts, including low white blood cell counts (neutropenia), low red blood cell counts (anemia), and low platelet counts (thrombocytopenia). This can increase the risk of infections, fatigue, and bleeding.
• Cardiovascular Effects: Farydak may lead to heart-related side effects, including heart rhythm abnormalities and heart failure. Patients with pre-existing heart conditions may be at higher risk.
• Liver Toxicity: Farydak can cause liver damage, leading to elevated liver enzymes and potential liver failure. Regular monitoring of liver function tests is typically recommended during treatment.
• Infections: Farydak can suppress the immune system, increasing the risk of infections. Patients should be vigilant for signs of infection and may require prophylactic antibiotics or antiviral medications.
• Bleeding: Farydak can increase the risk of bleeding, including gastrointestinal bleeding and hemorrhage. Patients should be cautious, especially if they have a history of bleeding disorders or are taking blood-thinning medications.
• Skin Reactions: Some patients may experience skin reactions such as rash, itching, or dry skin while taking Farydak.
• Electrolyte Imbalance: Farydak may cause electrolyte imbalances, including low potassium levels (hypokalemia) and low magnesium levels (hypomagnesemia), which can lead to muscle weakness and other symptoms.
• Tumor Lysis Syndrome: In rare cases, Farydak can cause tumor lysis syndrome, a condition characterized by the rapid breakdown of cancer cells, leading to metabolic abnormalities and organ damage.

It’s essential to report any side effects or concerns to your healthcare provider promptly. They can provide guidance on managing side effects and may adjust your treatment regimen if necessary to minimize discomfort and maximize effectiveness.

What should I know about storage and disposal of this medication?

Storage and disposal instructions for Farydak:

• Storage: Farydak should be stored at room temperature between 68°F to 77°F (20°C to 25°C) in its original container. Keep the container tightly closed and protect it from moisture and light.
• Keep away from children and pets: Store Farydak in a safe place out of the reach of children and pets, as it can be harmful if accidentally ingested.
• Disposal: Dispose of any unused or expired Farydak tablets properly according to local regulations. Do not flush them down the toilet or pour them down the drain. Check with your pharmacist or local waste disposal facility for guidance on how to dispose of medications safely.

In case of emergency/overdose

In case of emergency or overdose of Farydak, take the following steps:

• Contact emergency medical services: If you suspect an overdose or experience severe side effects such as difficulty breathing, fainting, or seizures, seek immediate medical attention by calling emergency services or going to the nearest emergency room.
• Poison control: If you believe someone has ingested Farydak accidentally or taken more than the prescribed dose, contact your local poison control center or emergency room for guidance.
• Provide information: When seeking medical help for an overdose, be prepared to provide information about the medication ingested, the amount taken if known, and any symptoms experienced.

What other information should I know?

• Side effects: Farydak may cause side effects such as nausea, diarrhea, fatigue, loss of appetite, and low blood cell counts. It’s essential to report any side effects to your healthcare provider promptly.
• Regular monitoring: Your doctor will monitor your blood counts and liver function regularly while you are taking Farydak to assess your response to treatment and monitor for any potential side effects.
• Drug interactions: Farydak may interact with other medications, including over-the-counter drugs and supplements. Before starting Farydak, inform your healthcare provider about all medications you are taking to avoid potential interactions.
• Follow-up appointments: Attend all scheduled appointments with your healthcare provider while taking Farydak to monitor your progress and adjust treatment as needed.
• Pregnancy and breastfeeding: Farydak can harm an unborn baby, so it’s essential to use effective birth control while taking this medication and avoid breastfeeding. If you are pregnant or planning to become pregnant, discuss the risks and benefits of Farydak with your doctor.

Always follow your healthcare provider’s instructions and ask any questions you may have about Farydak or its use.