WARNING

Exjade (deferasirox) is a medication used to treat chronic iron overload in patients who receive regular blood transfusions. While it can be effective, there are potential risks associated with its use:

• Kidney and Liver Problems: Exjade may cause kidney and liver problems, including acute kidney injury and liver failure. Monitoring of kidney and liver function is essential during treatment.
• Gastrointestinal Issues: Common side effects include nausea, vomiting, diarrhea, and abdominal pain. In some cases, severe gastrointestinal bleeding can occur.
• Skin Reactions: Exjade may cause skin rashes, itching, and other allergic reactions. Severe skin reactions like Stevens-Johnson syndrome have been reported, although rare.
• Auditory and Visual Changes: Some patients may experience changes in hearing or vision while taking Exjade. Regular monitoring of auditory and visual function is recommended.
• Bone Marrow Suppression: Exjade can suppress bone marrow function, leading to anemia, thrombocytopenia, and leukopenia. Regular blood tests are necessary to monitor blood cell counts.
• Interactions with Other Medications: Exjade may interact with other medications, potentially increasing the risk of adverse effects or reducing its effectiveness.
• Long-term Safety: The long-term safety of Exjade, particularly with prolonged use, is still being studied. Some concerns exist regarding its effects on growth and development in pediatric patients.

It’s important for patients taking Exjade to be closely monitored by their healthcare providers and to report any unusual symptoms or side effects promptly.

Why is this medication prescribed?

Exjade is typically taken once daily, usually on an empty stomach, at least 30 minutes before eating. It comes in the form of tablets that should be swallowed whole with water or dispersed in water for those who have difficulty swallowing. The dosage is based on the patient’s weight and is determined by their healthcare provider.

It’s crucial to follow the prescribed dosage and administration instructions precisely. Additionally, regular monitoring of kidney and liver function, as well as blood counts, is necessary during treatment to monitor for any potential side effects or complications. Any concerns or adverse effects should be reported to the healthcare provider promptly

How should this medicine be used?

Exjade is typically taken once daily, usually on an empty stomach, at least 30 minutes before eating. It comes in the form of tablets that should be swallowed whole with water or dispersed in water for those who have difficulty swallowing. The dosage is based on the patient’s weight and is determined by their healthcare provider.

It’s crucial to follow the prescribed dosage and administration instructions precisely. Additionally, regular monitoring of kidney and liver function, as well as blood counts, is necessary during treatment to monitor for any potential side effects or complications. Any concerns or adverse effects should be reported to the healthcare provider promptly.

Other uses for this medicine

Some potential off-label uses of Exjade may include:

• Iron overload caused by hereditary hemochromatosis.
• Iron overload in patients with myelodysplastic syndromes (MDS).
• Iron overload in patients with certain types of chronic liver disease.

What special precautions should I follow?

Regarding special precautions for taking Exjade, here are some key points:

• Medical History: Before starting Exjade, inform your healthcare provider about any medical conditions you have, especially kidney or liver problems, as well as any medications you are currently taking.
• Pregnancy and Breastfeeding: Exjade may harm an unborn baby, so it’s important to discuss the risks and benefits with your doctor if you are pregnant or planning to become pregnant. It’s also not recommended to breastfeed while taking Exjade, as it may pass into breast milk.
• Monitoring: Regular monitoring of kidney and liver function, as well as blood counts, is essential during treatment with Exjade. Your healthcare provider will determine the frequency of these tests based on your individual circumstances.
• Drug Interactions: Exjade may interact with other medications, including certain antacids, anticoagulants, and other drugs that affect kidney function. Make sure your healthcare provider is aware of all medications you are taking to avoid potential interactions.
• Adverse Effects: Be vigilant for any signs of allergic reactions, skin rashes, gastrointestinal issues, changes in hearing or vision, or any other unusual symptoms while taking Exjade. Report any concerns to your healthcare provider promptly.
• Dosage and Administration: Take Exjade exactly as prescribed by your doctor. Do not alter the dosage or stop taking it without consulting your healthcare provider.

By following these precautions and staying in close communication with your healthcare provider, you can help ensure the safe and effective use of Exjade.

What special dietary instructions should I follow?

Regarding special dietary instructions for Exjade, it is typically recommended to take the medication on an empty stomach, at least 30 minutes before eating. This allows for better absorption. However, if you experience gastrointestinal discomfort, you can take Exjade with food. Avoid consuming foods or beverages high in iron, as they may counteract the effects of Exjade.

What should I do if I forget a dose?

If you forget to take a dose of Exjade, take it as soon as you remember, unless it is almost time for your next scheduled dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are unsure about what to do, consult your healthcare provider or pharmacist for guidance.

What side effects can this medication cause?

Exjade (deferasirox) can cause various side effects, ranging from mild to severe. Common side effects may include:

• Nausea and Vomiting: Some individuals may experience nausea and vomiting, especially when starting treatment with Exjade. Taking the medication with food or adjusting the dosage may help alleviate these symptoms.
• Abdominal Pain: Stomach pain or discomfort is another common side effect of Exjade. This may include cramping or bloating.
• Diarrhea or Constipation: Changes in bowel habits, such as diarrhea or constipation, can occur while taking Exjade. Staying hydrated and consuming a balanced diet rich in fiber may help manage these symptoms.
• Skin Reactions: Exjade may cause skin rashes, itching, or other allergic reactions in some individuals. Severe skin reactions such as Stevens-Johnson syndrome are rare but possible.
• Headache: Headaches are a relatively common side effect of Exjade treatment. These headaches may range from mild to moderate in intensity.
• Auditory and Visual Changes: Some patients may experience changes in hearing or vision while taking Exjade. Regular monitoring of auditory and visual function is recommended.
• Bone Marrow Suppression: Exjade can suppress bone marrow function, leading to anemia, thrombocytopenia (low platelet count), and leukopenia (low white blood cell count). Regular blood tests are necessary to monitor blood cell counts.
• Kidney and Liver Problems: Exjade may cause kidney and liver problems, including acute kidney injury and liver failure. Monitoring of kidney and liver function is essential during treatment.
• Gastrointestinal Bleeding: In rare cases, Exjade may cause severe gastrointestinal bleeding. Seek medical attention immediately if you experience symptoms such as black, tarry stools or vomiting blood.
• Other Potential Side Effects: Other less common side effects of Exjade may include fatigue, dizziness, shortness of breath, and allergic reactions.

It’s important to report any side effects or unusual symptoms to your healthcare provider promptly. They can help manage side effects and adjust your treatment plan if necessary.

What should I know about storage and disposal of this medication?

For storage and disposal of Exjade (deferasirox), here’s what you should know:

• Storage: Store Exjade tablets at room temperature away from moisture and heat. Keep the medication in its original container, tightly closed, and out of reach of children and pets.
• Disposal: Dispose of any unused or expired Exjade tablets properly according to local regulations or guidelines. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Consult your pharmacist or local waste disposal authority for proper disposal methods.

In case of emergency/overdose

In case of emergency or overdose of Exjade, take the following steps:

• Seek Medical Attention: If you suspect an overdose or experience severe symptoms such as severe stomach pain, vomiting blood, or difficulty breathing, seek immediate medical attention or call your local poison control center.
• Symptom Management: While waiting for medical help, you can try to manage symptoms by staying hydrated and comfortable. Do not attempt to induce vomiting unless instructed by a healthcare professional.

What other information should I know?

• Regular Monitoring: Follow your healthcare provider’s instructions for regular monitoring of kidney and liver function, as well as blood counts, during treatment with Exjade. This helps ensure the medication’s safety and effectiveness.
• Patient Education: Be sure to understand how to take Exjade correctly, including dosage instructions, potential side effects, and special precautions. Ask your healthcare provider or pharmacist if you have any questions or concerns.
• Follow-up Visits: Attend all scheduled follow-up appointments with your healthcare provider to monitor your response to Exjade treatment and adjust your treatment plan as needed.
• Drug Interactions: Inform your healthcare provider about all medications, supplements, and herbal products you are taking before starting Exjade, as it may interact with certain drugs.
• Medical Alert: Carry a medical alert card or wear a medical alert bracelet indicating that you are taking Exjade. This can be helpful in case of emergencies or if you require medical treatment from healthcare providers who may not be familiar with your medical history.

By following these guidelines and staying informed about Exjade, you can help ensure safe and effective treatment.