WARNING

Evista (raloxifene) is a medication primarily used to treat and prevent osteoporosis in postmenopausal women. However, like any medication, it carries potential risks. Here are some of the main risks associated with taking Evista:

• Blood clots: Evista may increase the risk of blood clots, particularly in the legs (deep vein thrombosis) or lungs (pulmonary embolism). This risk is higher in women with a history of blood clots or who are immobile for long periods.
• Stroke: Some studies have suggested an increased risk of stroke, particularly in women with a history of cardiovascular disease or risk factors for stroke.
• Hot flashes: While Evista can help reduce the risk of osteoporosis and breast cancer, it may also cause hot flashes, similar to those experienced during menopause.
• Increased risk of uterine cancer: Evista may slightly increase the risk of developing uterine cancer. This risk is higher in women who have not had a hysterectomy.
• Other side effects: Other potential side effects of Evista include leg cramps, swelling of the legs or feet, joint pain, and flu-like symptoms.

It’s essential to discuss the potential risks and benefits of taking Evista with your healthcare provider, especially if you have a history of blood clots, stroke, or other medical conditions. Your doctor can help determine if Evista is the right treatment option for you and monitor you for any potential side effects.

Why is this medication prescribed?

Evista (raloxifene) is prescribed for several purposes:

• Treatment of osteoporosis: It’s used to treat osteoporosis in postmenopausal women. Osteoporosis is a condition characterized by weakened bones, making them more prone to fractures.
• Prevention of osteoporosis: Evista can also be prescribed to prevent osteoporosis in postmenopausal women who are at high risk of developing the condition.
• Reduction of breast cancer risk: Evista is approved for reducing the risk of invasive breast cancer in postmenopausal women with osteoporosis or at high risk of breast cancer. It’s also used to reduce the risk of invasive breast cancer in postmenopausal women who have not been diagnosed with osteoporosis but have a high risk of breast cancer.

How should this medicine be used?

As for how Evista should be used:

• Dosage: Evista comes as a tablet to take by mouth. It is usually taken once a day with or without food. The typical dosage of Evista for osteoporosis treatment and prevention is 60 mg once daily, with or without food.
• Duration: Your doctor will determine how long you should take Evista based on your individual circumstances and medical history. It’s essential to follow your doctor’s instructions regarding the duration of treatment.
• Regular follow-up: While taking Evista, your doctor will likely schedule regular follow-up appointments to monitor your response to the medication and check for any potential side effects.
• Other considerations: It’s important to continue with other measures to promote bone health, such as a balanced diet rich in calcium and vitamin D, regular weight-bearing exercise, and lifestyle modifications to reduce the risk of falls.

Always take Evista exactly as prescribed by your healthcare provider and never adjust your dosage without consulting them first. If you have any questions or concerns about how to take Evista, be sure to discuss them with your doctor or pharmacist.

Other uses for this medicine

In addition to treating and preventing osteoporosis, Evista may also be prescribed for:

• Reducing the risk of invasive breast cancer in postmenopausal women with osteoporosis or at high risk for breast cancer.
• Lowering the risk of invasive breast cancer in postmenopausal women with osteoporosis or at high risk for breast cancer.

What special precautions should I follow?

As for precautions when taking Evista, here are some important points to consider:

• Pregnancy: Evista should not be used during pregnancy, as it can cause harm to the fetus. If you become pregnant while taking Evista, you should stop taking it immediately and consult your doctor.
• Blood clots: Evista may increase the risk of blood clots, particularly in the legs (deep vein thrombosis) or lungs (pulmonary embolism). It’s essential to be aware of the signs and symptoms of blood clots, such as swelling, pain, or redness in the legs, chest pain, or difficulty breathing, and seek medical attention if you experience any of these.
• Stroke: Some studies have suggested a potential increased risk of stroke, particularly in women with a history of cardiovascular disease. Discuss your risk factors with your doctor before starting Evista.
• Breast cancer risk: While Evista can reduce the risk of invasive breast cancer in some women, it may increase the risk of certain types of non-invasive breast cancer. Your doctor can help assess your individual risk factors and determine if Evista is appropriate for you.
• Liver function: Evista may affect liver function, so it’s essential to have regular liver function tests while taking this medication.

Always follow your doctor’s instructions and discuss any concerns or questions you have about Evista or any other medication you’re taking.

What special dietary instructions should I follow?

• There are no specific dietary restrictions associated with taking Evista. However, maintaining a balanced diet rich in calcium and vitamin D is important for bone health, especially when taking medications for osteoporosis.
• Foods high in calcium include dairy products, leafy green vegetables, almonds, and fortified foods such as orange juice and cereals.
• Vitamin D can be obtained from sources such as fatty fish (salmon, tuna), egg yolks, fortified foods, and sunlight exposure.

What should I do if I forget a dose?

• If you miss a dose of Evista, take it as soon as you remember, unless it’s almost time for your next scheduled dose. In that case, skip the missed dose and continue with your regular dosing schedule.
• Do not take a double dose to make up for a missed one.
• If you’re unsure about what to do, consult your healthcare provider or pharmacist for guidance.

What side effects can this medication cause?

Evista (raloxifene) may cause some side effects, although not everyone will experience them. Common side effects of Evista include:

• Hot flashes
• Leg cramps
• Swelling of the legs and feet
• Joint pain
• Increased sweating
• Flu-like symptoms
• Dizziness
• Headache
• Nausea
• Stomach pain or upset stomach
• Sinusitis
• Infection

Less common but more severe side effects may include:

• Blood clots, especially in the legs (deep vein thrombosis) or lungs (pulmonary embolism)
• Stroke
• Increased risk of developing certain types of uterine cancer (endometrial cancer)
• Increased triglyceride levels
• Vision changes, including blurred vision or difficulty seeing colors

It’s important to contact your healthcare provider if you experience any of these side effects while taking Evista. Additionally, if you notice any other unusual symptoms or have concerns about the medication, don’t hesitate to discuss them with your doctor or pharmacist.

What should I know about storage and disposal of this medication?

Storage and disposal of Evista:

• Store Evista tablets at room temperature away from moisture and heat.
• Keep Evista out of reach of children and pets.
• Do not use Evista after the expiration date printed on the label.
• Dispose of any unused or expired Evista medication properly according to local regulations or guidelines. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Instead, dispose of them through a medication take-back program or by using a drug disposal kit.

In case of emergency/overdose

• If you suspect an overdose or experience severe symptoms such as difficulty breathing, fainting, or loss of consciousness, seek immediate medical attention or call your local poison control center.
• Be prepared to provide information about the amount of Evista ingested, the time of ingestion, and any symptoms experienced.

What other information should I know?

• Regularly monitor your bone density and follow up with your healthcare provider as recommended.
• Report any unusual symptoms or side effects to your doctor promptly.
• Attend all scheduled appointments with your healthcare provider for monitoring and evaluation of your response to treatment.
• Inform other healthcare professionals, such as dentists or surgeons, about your use of Evista before undergoing any medical procedures.
• Avoid smoking and limit alcohol consumption while taking Evista, as these can increase the risk of side effects.
• Evista is not indicated for use in premenopausal women or men and should only be used under the supervision of a healthcare provider.

Always follow your doctor’s instructions and consult them or a pharmacist if you have any questions or concerns about taking Evista.