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Etodolac

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WARNING

Nonsteroidal anti-inflammatory drugs (NSAIDs) other than aspirin, such etodolac, may increase the chance of having a heart attack or stroke compared to those who do not take them. These occurrences have the potential to be fatal and come about suddenly. For those who use NSAIDs often, this risk can be increased. If you have had a recent heart attack, you shouldn’t take an NSAID like etodolac unless your doctor specifically instructs you to. Inform your doctor if you smoke, have high cholesterol, high blood pressure, or diabetes, or if you or anybody in your family has ever experienced any of these conditions. You should also mention any history of heart disease, a heart attack, or a stroke. If you develop any of the following signs or symptoms, get immediate emergency medical attention: chest pain, shortness of breath, weakness on one side or arm, or slurred speech.

Etodolac should not be taken just before or immediately after a coronary artery bypass graft (CABG; a form of cardiac surgery).

NSAIDs, including etodolac, can result in stomach or intestine ulcers, bleeding, or holes. These issues can arise at any point during therapy, without any prior symptoms, and they have the potential to be fatal. If you take NSAIDs frequently, are older, are in poorer health, or consume a lot of alcohol while taking etodolac, your risk may be higher. Inform your physician if you use any of the following drugs: Aspirin, warfarin (Coumadin, Jantoven), and other anticoagulants (sometimes known as “blood thinners”); oral steroids such dexamethasone, methylprednisolone (Medrol), and prednisone (Rayos); additional NSAIDs like ibuprofen (Advil, Motrin) and naproxen (Aleve, Naprosyn); selective serotonin reuptake inhibitors (SSRIs), including paroxetine (Brisdelle, Paxil, Pexeva), fluoxetine (Prozac, Sarafem, Selfemra, in Symbyax), fluvoxamine (Luvox), citalopram (Celexa), and sertraline (Zoloft); or SNRIs (serotonin norepinephrine reuptake inhibitors), which include desvenlafaxine (Khedezla, Pristiq), duloxetine (Cymbalta), and venlafaxine (Effexor XR). Additionally, let your doctor know if you suffer from or have ever suffered from ulcers, gastrointestinal bleeding, or any other bleeding disorders. Call your doctor and stop taking etodolac if you notice any of the following signs: stomach pain, heartburn, bloody or resembling coffee grounds vomit, blood in the stool, or tarry or black faeces.

Keep all of your appointments with your physician and the lab. In order to determine how your body is responding to etodolac, your doctor will likely closely monitor your symptoms and run a number of tests. Inform your physician about your feelings so that they can prescribe the ideal dosage of medication to cure your problem with the least chance of negative side effects.

The patient information sheet (Medication Guide) from the manufacturer will be sent to you by your doctor or chemist when you start treatment with etodolac and at each time you get a new prescription. If you have any questions, carefully read the information and ask your doctor or chemist. The Medication Guide is also available on the manufacturer’s website or the Food and Drug Administration (FDA) website (http://www.fda.gov/drugs/drugsafety/ucm085729.htm).

Why is this medication prescribed?

In order to treat osteoarthritis (arthritis brought on by the breakdown of the lining of the joints) and rheumatoid arthritis (arthritis brought on by swelling of the lining of the joints), etodolac is available as tablets, capsules, and extended-release (long-acting) tablets. Etodolac pills and capsules are also used to treat pain from other sources. Etodolac belongs to a group of drugs known as NSAIDs. It functions by preventing the body from producing a chemical that causes discomfort, fever, and inflammation.

How should this medicine be used?

There are three oral dosage forms of etodolac: tablets, capsules, and extended-release tablets. The extended-release tablet is often taken once day, whereas the tablet and capsule are typically given two to three times daily to treat arthritis. The tablets and capsules are typically given every 6 to 8 hours to treat pain from different sources. Every day, take etodolac at around the same time(s). Ask your doctor or chemist to explain any instructions on your prescription label that you are unsure about following. Todolac should be taken as prescribed. Never take it in larger or less amounts or more frequently than directed by your doctor.

Do not split, chew, or crush the extended-release pills; instead, swallow them whole.

Your doctor may put you on a high dose of etodolac for arthritis and then reduce it once your symptoms are under control. You might not experience all of the benefits of this drug for 1 to 2 weeks.

Other uses for this medicine

Ask your doctor or chemist for more details if you believe this drug should be used for something else.

What special precautions should I follow?

Before taking etodolac,

  • Aspirin, other NSAIDs including ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn), or any other drugs, as well as any of the inactive chemicals in etodolac tablets, capsules, or extended-release tablets, should be disclosed to your doctor and chemist if you are allergic to any of these substances. Request an ingredient list from your chemist.
  • Inform your doctor and chemist about all prescription and over-the-counter drugs, vitamins, dietary supplements, and herbal products that you are now taking or intend to use. Mention any of the following as well as the medications specified in the IMPORTANT WARNING section. the angiotensin-converting enzyme (ACE) inhibitors benazepril (Lotensin, in Lotrel), enalapril, fosinopril, lisinopril (in Zestoretic), moexipril (Univasc), captopril, ramipril (Altace), perindopril (Aceon, in Prestalia), quinapril (Accupril, in Quinaretic), and trandolapril (Mavik, in Tarka); angiotensin receptor blockers such candesartan (Atacand, in Atacand HCT), eprosartan (Teveten), irbesartan (Avapro, in Avalide), and losartan (Cozaar, in Hyzaar), olmesartan (Benicar, Azor, Benicar HCT, Tribenzor), telmisartan (Micardis, Micardis HCT, Twynsta), and valsartan (in Exforge HCT); cyclosporine (Gengraf, Neoral, Sandimmune); digoxin (Lanoxin), diuretics (‘water pills’), lithium (Lithobid), and methotrexate (Otrexup, Rasuvo, Trexall) are examples of these medications. Your doctor might need to adjust the dosage of your drugs or keep a close eye on you for side effects.
  • Inform your physician if you have or have ever had asthma, particularly if you also suffer from chronic sinusitis, frequent runny or stuffy nose, nasal polyps (swelling of the nasal lining), heart failure, swelling of the hands, feet, ankles, or lower legs, or kidney or liver problems.
  • Inform your doctor if you are expecting, especially if you are 20 weeks or older, planning to get pregnant, or planning to breastfeed. Call your doctor if you become pregnant while taking etodolac. If etodolac is consumed beyond 20 weeks of pregnancy, it may harm the foetus and complicate delivery. Unless specifically instructed to do so by your doctor, avoid using etodolac around or after 20 weeks of pregnancy.
  • If you are 75 years of age or older, discuss the advantages and disadvantages of taking etodolac with your doctor. Never use this medication for a longer time or at a greater dose than what your doctor has prescribed.
  • Inform your doctor or dentist that you are taking etodolac if you are having surgery, including dental surgery.

What special dietary instructions should I follow?

Keep eating normally unless your doctor instructs you otherwise.

What should I do if I forget a dose?

If you miss a dosage, take it as soon as you recall. If the next dose is soon due, skip the missed one and carry on with your regular dosing plan. To make up for a missing dose, do not take a second one.

What side effects can this medication cause?

Etodolac could have negative effects. If any of these symptoms are severe or do not go away, let your doctor know right once:

  • Constipation
  • Diarrhea
  • Bloating or gas
  • Vomiting
  • Headache
  • Dizziness
  • Hearing ringing
  • Clogged nose
  • Unwell throat
  • Fuzzy vision

Some adverse effects can be very harmful. Call your doctor right away if you have any of the following symptoms or those listed in the IMPORTANT WARNING section. Till you speak to your doctor, stop taking etodolac.

  • Rise in weight without cause
  • Respiratory issues or lack of breath
  • Abdomen, lower legs, or foot and ankles swelling
  • Eyes, face, lips, tongue, throat, or hands swelling
  • Cold or fever
  • Blisters
  • Rash
  • Itching
  • Hives
  • Hoarseness
  • Having trouble swallowing
  • Eyes or skin that have a yellow tint
  • Extreme fatigue
  • Uncommon bruising or bleeding
  • Not enough energy
  • Reduced appetite
  • Stomach ache in the top right corner
  • Flu-like signs
  • Light skin
  • Rapid heart rate
  • Urine that is hazy, discoloured, or bloody
  • Uncomfortable or challenging urinating
  • Back ache

Other negative effects of etodolac are possible. If you experience any strange issues while taking this medicine, contact your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting program online at http://www.fda.gov/Safety/MedWatch or by phone at 1-800-332-1088 if you have a serious side event.

What should I know about storage and disposal of this medication?

Keep this medication tightly closed in the original container and out of the reach of children. Etodolac pills shouldn’t be prepared in advance; instead, leave them in their original packaging until you’re ready to consume them. Etodolac should be kept at room temperature, away from sources of extreme heat, and dry (not in the bathroom).

As many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for young children to open, it is crucial to keep all medications out of sight and out of reach of children. Always lock safety caps and promptly stash medication up and away from young children where it is out of their sight and reach to prevent poisoning.http://www.upandaway.org

Unused prescriptions must be disposed of carefully to prevent pets, kids, and other people from ingesting them. You should not, however, dispose of this medication in the toilet. Instead, utilizing a medicine take-back program is the easiest approach to get rid of your medication. To find out about take-back programs in your area, speak with your chemist or the garbage/recycling agency in your city. If you do not have access to a take-back program, see the FDA’s Safe Disposal of Medicines website at http://goo.gl/c4Rm4p for additional information.

In case of emergency/overdose

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Additionally, information can be found online at https://www.poisonhelp.org/help. Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

Overdose signs could include the following:

  • Not enough energy
  • Drowsiness
  • Nausea
  • Vomiting
  • Abdominal pain
  • Viscous, black, or bloody stool
  • Vomit that is reddish-colored or resembles coffee grounds
  • Coma (a temporary loss of consciousness)

What other information should I know?

Inform the lab staff and your doctor that you are taking etodolac prior to any laboratory test.

You should be aware that etodolac may affect the results of a urine test for ketones if you have diabetes and do such a test. Consult your physician.

No one else should take your medication. Any queries you may have regarding prescription refills should be directed to your chemist.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Lodine®
  • Lodine® XL
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