Why is this medication prescribed?
Etelcalcetide injection is prescribed primarily for the treatment of secondary hyperparathyroidism (HPT) in adult patients with chronic kidney disease (CKD) on hemodialysis. Secondary HPT is a condition where the parathyroid glands produce too much parathyroid hormone due to decreased kidney function, leading to imbalances in calcium, phosphorus, and vitamin D metabolism.
Etelcalcetide works by binding to and activating the calcium-sensing receptors on the parathyroid gland, thereby reducing the secretion of parathyroid hormone. By controlling parathyroid hormone levels, it helps in regulating calcium, phosphorus, and vitamin D metabolism in patients undergoing hemodialysis.
How should this medicine be used?
The usage of Etelcalcetide injection is typically as follows:
- Administration Route: Etelcalcetide is administered intravenously (IV), usually during hemodialysis sessions.
- Dosage: The dosage is individualized based on the patient’s serum parathyroid hormone (PTH) levels and calcium levels. The initial dose and subsequent adjustments are determined by the treating healthcare provider.
- Administration: Healthcare professionals administer the injection into the venous line of the dialysis tubing at the end of the hemodialysis session.
- Monitoring: Patients are closely monitored for changes in serum calcium, phosphorus, and PTH levels, as well as any adverse reactions.
- Titration: Dosage adjustments may be necessary based on the patient’s response to treatment and changes in laboratory parameters.
It’s crucial for patients to follow their healthcare provider’s instructions precisely regarding the dosage and administration of Etelcalcetide injection. Additionally, they should report any adverse effects or concerns to their healthcare provider promptly.
Other uses for this medicine
Etelcalcetide injection is primarily used for the treatment of secondary hyperparathyroidism (HPT) in adult patients with chronic kidney disease (CKD) who are on hemodialysis. However, it’s important to note that healthcare providers may sometimes prescribe medications off-label for conditions other than those officially approved by regulatory agencies like the FDA. If you’re considering alternative uses for Etelcalcetide injection, it’s crucial to consult with a qualified healthcare professional who can provide personalized advice based on your specific medical situation.
What special precautions should I follow?
Regarding special precautions for Etelcalcetide injection use, here are some important points to consider:
- Allergies: Inform your healthcare provider if you have any allergies to Etelcalcetide or any other medications.
- Medical History: Provide your healthcare provider with a comprehensive medical history, especially if you have a history of seizures, heart rhythm problems (arrhythmias), or conditions affecting your calcium levels.
- Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss the potential risks and benefits of using Etelcalcetide injection with your healthcare provider.
- Drug Interactions: Inform your healthcare provider about all the medications, supplements, and herbal products you are currently taking to avoid potential drug interactions.
- Monitoring: Regular monitoring of serum calcium, phosphorus, and parathyroid hormone (PTH) levels is essential during treatment with Etelcalcetide injection to ensure proper dosage adjustments and monitor for any adverse effects.
- Administration: Etelcalcetide injection should only be administered intravenously (IV) by healthcare professionals during hemodialysis sessions. Patients should not attempt to self-administer this medication.
Always follow your healthcare provider’s instructions carefully regarding the use of Etelcalcetide injection and any associated precautions. If you have any questions or concerns, don’t hesitate to discuss them with your healthcare provider.
What special dietary instructions should I follow?
Regarding special dietary instructions:
- Calcium and Phosphorus Intake: Your healthcare provider may recommend dietary restrictions on foods high in calcium and phosphorus to help manage secondary hyperparathyroidism. Follow any dietary recommendations provided by your healthcare provider.
- Fluid Intake: Your healthcare provider may also provide guidelines for fluid intake during hemodialysis sessions. Adhering to these recommendations can help maintain proper fluid balance in your body.
What should I do if I forget a dose?
- Contact Your Healthcare Provider: If you miss a dose of Etelcalcetide Injection, notify your healthcare provider as soon as possible. They can advise you on what steps to take next.
- Rescheduling: Your healthcare provider may instruct you to reschedule the missed dose or adjust your treatment schedule accordingly.
- Do Not Double Dose: Do not double the dose to make up for a missed dose unless instructed to do so by your healthcare provider. Taking too much medication can increase the risk of side effects.
What side effects can this medication cause?
Etelcalcetide injection, like any medication, can cause side effects in some individuals. It’s essential to be aware of these potential side effects and to promptly inform your healthcare provider if you experience any adverse reactions. Common side effects of Etelcalcetide injection may include:
- Hypocalcemia: Low levels of calcium in the blood, which may cause symptoms such as muscle cramps, tingling sensations, or spasms.
- Nausea: A feeling of discomfort or queasiness in the stomach, often leading to the urge to vomit.
- Vomiting: The act of forcefully expelling the contents of the stomach through the mouth.
- Muscle Spasms: Involuntary contractions or tightening of muscles, which may cause pain or discomfort.
- Headache: A pain or discomfort in the head or upper neck region.
- Diarrhea: Frequent passage of loose, watery stools.
- Hypotension: Low blood pressure, which may lead to symptoms such as dizziness, lightheadedness, or fainting.
- Nasopharyngitis: Inflammation of the nasal passages and throat, often accompanied by symptoms such as congestion, runny nose, or sore throat.
- Upper Respiratory Tract Infection: Infection of the upper respiratory system, which may cause symptoms such as coughing, sneezing, or nasal congestion.
- Musculoskeletal Pain: Pain or discomfort affecting the muscles, bones, or joints.
It’s important to note that this list may not include all possible side effects of Etelcalcetide injection. Additionally, some individuals may experience severe or uncommon side effects that are not listed here. If you experience any new or worsening symptoms after starting treatment with Etelcalcetide injection, contact your healthcare provider for further evaluation and guidance. They can help determine the appropriate course of action based on your specific situation.
What should I know about storage and disposal of this medication?
Storage and disposal of Etelcalcetide Etelcalcetide:
- Storage:
- Store Etelcalcetide Etelcalcetide vials in the refrigerator at 2°C to 8°C (36°F to 46°F).
- Do not freeze.
- Protect the vials from light by keeping them in the original carton until ready for use.
- Once removed from the refrigerator, Etelcalcetide Injection can be kept at room temperature up to 25°C (77°F) for up to 14 days.
- Do not expose the vials to temperatures above 25°C (77°F) or excessive heat.
- Disposal:
- Dispose of any unused or expired Etelcalcetide Injection vials properly according to local regulations or guidelines.
- Do not dispose of medications in wastewater (e.g., down the sink or toilet) unless instructed to do so. Contact your pharmacist or local waste disposal company for proper disposal instructions.
In case of emergency/overdose
- In case of an overdose or emergency, such as severe hypocalcemia (low blood calcium levels) or severe adverse reactions, seek immediate medical attention or contact your local poison control center.
- Be prepared to provide information about the medication taken, dosage, and time of ingestion.
What other information should I know?
- Keep all appointments for laboratory tests and follow-up visits with your healthcare provider.
- Inform your healthcare provider about all medications, supplements, and herbal products you are taking, as they may interact with Etelcalcetide Injection.
- Report any new or worsening symptoms, side effects, or concerns to your healthcare provider promptly.
- Avoid driving or operating heavy machinery if you experience dizziness or other side effects that may impair your ability to do so safely.
- Keep Etelcalcetide Injection out of reach of children and pets.
- Follow proper injection techniques and safety precautions as instructed by your healthcare provider or healthcare professional.
It’s important to adhere to storage and disposal guidelines to ensure the effectiveness and safety of the medication and to minimize potential harm to others. If you have any questions or concerns about Etelcalcetide Injection, including storage, disposal, or emergency procedures, consult your healthcare provider or pharmacist for further guidance.
