WARNING

Estrace Cream is a topical medication containing estradiol, a form of estrogen hormone. While it’s commonly prescribed to treat symptoms of menopause such as vaginal dryness and irritation, there are potential risks associated with its use. Some of these risks include:

• Increased Risk of Cancer: Long-term use of estrogen therapy, including Estrace Cream, may increase the risk of certain cancers such as breast cancer and endometrial cancer. This risk tends to increase with higher doses and prolonged use.
• Cardiovascular Risks: Estrogen therapy may increase the risk of cardiovascular events such as heart attacks, strokes, and blood clots, particularly in women with pre-existing cardiovascular conditions or those at high risk.
• Blood Clot Formation: Estrogen can promote blood clot formation, which may lead to serious complications such as deep vein thrombosis (DVT) or pulmonary embolism (PE).
• Endometrial Hyperplasia: In women who have not had a hysterectomy, estrogen therapy alone can lead to thickening of the lining of the uterus (endometrial hyperplasia), which may increase the risk of endometrial cancer.
• Gallbladder Disease: Estrogen therapy may increase the risk of developing gallbladder disease, including gallstones.
• Breast Changes: Some women may experience breast tenderness, enlargement, or changes in breast tissue density while using Estrace Cream.
• Other Side Effects: Other potential side effects of Estrace Cream may include headache, nausea, vaginal bleeding or spotting, mood changes, and fluid retention.

It’s important for individuals using Estrace Cream to discuss the potential risks and benefits with their healthcare provider, especially if they have a history of certain medical conditions or risk factors. Estrogen therapy should be used at the lowest effective dose for the shortest duration necessary to achieve treatment goals. Regular monitoring and follow-up with a healthcare provider are essential to manage risks associated with Estrace Cream use.

Why is this medication prescribed?

Estrace Cream is prescribed primarily to relieve symptoms of menopause, particularly vaginal dryness, itching, and irritation. These symptoms often occur due to decreased estrogen levels during menopause, which can lead to changes in the vaginal tissues. Estrace Cream helps replenish estrogen levels locally in the vaginal area, thereby reducing discomfort and improving vaginal health.

How should this medicine be used?

Here’s how Estrace Cream is typically used:

• Dosage: The dosage of Estrace Cream varies depending on the severity of symptoms and individual response to treatment. Your healthcare provider will prescribe the appropriate strength and dosage regimen for you.
• Administration: Estrace Cream is a topical medication meant for vaginal use only. It should be applied directly into the vagina using the applicator provided with the medication.
• Frequency: The usual dosing schedule for Estrace Cream is once daily, preferably at bedtime. However, your healthcare provider may adjust the frequency of use based on your specific needs and response to treatment.
• Duration: Treatment with Estrace Cream is typically short-term and aimed at relieving acute symptoms. Your healthcare provider will determine the duration of treatment based on your individual circumstances.
• Follow Instructions: It’s essential to follow your healthcare provider’s instructions carefully when using Estrace Cream. Use the prescribed amount of medication and avoid using it more often or in larger amounts than directed.
• Review Side Effects: Be aware of potential side effects associated with Estrace Cream use, and promptly report any adverse reactions to your healthcare provider.
• Regular Follow-Up: Your healthcare provider may schedule regular follow-up appointments to monitor your response to treatment and assess any potential side effects. These appointments are essential for ensuring the safe and effective use of Estrace Cream.
• Storage: Store Estrace Cream at room temperature, away from heat and moisture. Keep it out of reach of children and pets.

It’s important to discuss any questions or concerns about the use of Estrace Cream with your healthcare provider to ensure safe and effective treatment.

Other uses for this medicine

Other uses for Estrace Cream may include:

• Postmenopausal Symptoms: Besides treating vaginal symptoms of menopause, Estrace Cream may also help alleviate other symptoms like hot flashes and night sweats.
• Osteoporosis Prevention: Estrogen therapy, including the use of Estrace Cream, may be prescribed to prevent osteoporosis in postmenopausal women at high risk.
• Hormone Replacement Therapy: In some cases, Estrace Cream may be used as part of hormone replacement therapy to address hormonal imbalances associated with menopause.

What special precautions should I follow?

Special precautions should be followed when using Estrace Cream to ensure safe and effective treatment. Here are some key precautions to consider:

• Medical History: Before using Estrace Cream, inform your healthcare provider about your complete medical history, including any past or present medical conditions, allergies, surgeries, and medications you are currently taking.
• Breast Cancer Risk: Women with a history of breast cancer or those at high risk for breast cancer should use Estrace Cream cautiously, as estrogen therapy may increase the risk of breast cancer recurrence or new breast cancer development.
• Endometrial Cancer Risk: Estrace Cream should be used with caution in women who have not had a hysterectomy, as estrogen therapy alone may increase the risk of endometrial cancer. Your healthcare provider may prescribe progestin therapy in combination with Estrace Cream to reduce this risk.
• Cardiovascular Health: Estrogen therapy may increase the risk of cardiovascular events such as heart attacks and strokes, particularly in women with pre-existing cardiovascular conditions or those at high risk. Discuss your cardiovascular health with your healthcare provider before using Estrace Cream.
• Regular Monitoring: Regular monitoring by a healthcare provider is essential while using Estrace Cream to assess treatment response and monitor for any potential side effects or complications.
• Pregnancy and Breastfeeding: Estrace Cream is not indicated for use during pregnancy or breastfeeding. If you become pregnant while using Estrace Cream, notify your healthcare provider immediately.
• Interactions with Other Medications: Inform your healthcare provider about all medications, vitamins, and supplements you are taking, as they may interact with Estrace Cream and affect its efficacy or safety.
• Routine Examinations: Women using Estrace Cream should undergo regular gynecological examinations, including breast exams and pelvic exams, as recommended by their healthcare provider.

Following these precautions and guidelines can help ensure the safe and effective use of Estrace Cream for the intended purpose. Always consult with your healthcare provider if you have any questions or concerns about using this medication.

What special dietary instructions should I follow?

There are no specific dietary instructions associated with the use of Estrace Cream. However, maintaining a healthy and balanced diet is important for overall health, especially for individuals using hormone therapy. Your healthcare provider may recommend dietary modifications based on your individual health needs.

What should I do if I forget a dose?

If you forget to apply a dose of Estrace Cream, apply it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not apply extra cream to make up for a missed dose. If you are unsure about what to do, consult your healthcare provider or pharmacist for guidance.

What side effects can this medication cause?

Estrace Cream, like any medication, can cause side effects, although not everyone may experience them. Common side effects of Estrace Cream may include:

• Vaginal Irritation: This may manifest as itching, burning, or discomfort in the vaginal area.
• Vaginal Discharge: Some women may experience changes in vaginal discharge, such as an increase in discharge or changes in consistency.
• Headache: Headaches are a common side effect reported by some individuals using Estrace Cream.
• Breast Tenderness: Some women may experience breast tenderness or swelling while using Estrace Cream.
• Nausea: Nausea or gastrointestinal discomfort may occur in some individuals.
• Abdominal Pain: Some women may experience abdominal pain or discomfort while using Estrace Cream.
• Vaginal Bleeding: Spotting or light vaginal bleeding may occur, particularly during the first few months of treatment.
• Fluid Retention: Some individuals may experience fluid retention, leading to swelling or bloating.
• Mood Changes: Changes in mood, including mood swings or emotional fluctuations, are possible side effects of Estrace Cream.
• Skin Irritation: In some cases, application of the cream may cause skin irritation or redness at the site of application.
• Breast Enlargement: Some women may notice an increase in breast size while using Estrace Cream.
• Vision Changes: Blurred vision or other changes in vision have been reported as possible side effects, although they are less common.

It’s essential to note that not all individuals will experience these side effects, and some may experience none at all. Additionally, if any side effects persist or worsen over time, it’s important to inform your healthcare provider promptly.

Some side effects of Estrace Cream may be indicative of more serious complications. These can include:

• Severe allergic reactions (e.g., rash, itching, swelling of the face, tongue, or throat, severe dizziness, trouble breathing)
• Symptoms of a blood clot (e.g., sudden severe headache, weakness on one side of the body, sudden vision changes, chest pain, shortness of breath, leg swelling or pain)

If you experience any severe or concerning side effects, seek immediate medical attention. It’s important to discuss the risks and benefits of Estrace Cream with your healthcare provider before starting treatment.

What should I know about storage and disposal of this medication?

Storage and Disposal:

• Storage: Store Estrace Cream at room temperature (between 20-25°C or 68-77°F), away from heat, moisture, and direct light. Keep it out of reach of children and pets. Do not freeze.
• Disposal: Dispose of Estrace Cream properly according to local regulations or as instructed by your healthcare provider or pharmacist. Do not flush medications down the toilet or pour them into a drain unless instructed to do so.

In case of emergency/overdose

• In Case of Emergency: If you suspect an overdose or experience severe symptoms such as difficulty breathing or loss of consciousness after using Estrace Cream, seek emergency medical attention immediately. Call your local emergency services or go to the nearest emergency room.
• Overdose Symptoms: Symptoms of an overdose may include nausea, vomiting, vaginal bleeding, and other signs of estrogen overdose. Prompt medical attention is necessary to manage potential complications.

What other information should I know?

• Follow Instructions Carefully: Use Estrace Cream exactly as prescribed by your healthcare provider. Do not use more or less of it or use it more often than prescribed.
• Regular Follow-up: Attend regular follow-up appointments with your healthcare provider to monitor your response to treatment and assess any potential side effects or complications.
• Inform Healthcare Providers: Inform all healthcare providers involved in your care, including specialists and dentists, that you are using Estrace Cream. This information is important for avoiding potential drug interactions and ensuring comprehensive care.
• Breast Self-Examination: Perform regular breast self-examinations and report any lumps, changes, or abnormalities to your healthcare provider.
• Annual Physical Examinations: Women using Estrace Cream should undergo regular physical examinations, including pelvic examinations and breast examinations, as recommended by their healthcare provider.
• Medication Interactions: Inform your healthcare provider about all medications, vitamins, and supplements you are taking, as they may interact with Estrace Cream and affect its efficacy or safety.
• Review Side Effects: Be aware of potential side effects associated with Estrace Cream use, and promptly report any adverse reactions to your healthcare provider.
• Pregnancy and Breastfeeding: Estrace Cream is not indicated for use during pregnancy or breastfeeding. If you become pregnant while using Estrace Cream, notify your healthcare provider immediately.

Following these guidelines can help ensure the safe and effective use of Estrace Cream. If you have any questions or concerns about using this medication, consult your healthcare provider or pharmacist for further guidance.