Why is this medication prescribed?

Esbriet (pirfenidone) is prescribed primarily for the treatment of idiopathic pulmonary fibrosis, a chronic and progressive lung disease characterized by scarring (fibrosis) of the lungs. It works by reducing the production of fibroblasts and certain proteins that contribute to the scarring process, thereby slowing down the progression of the disease and preserving lung function.

How should this medicine be used?

Here are some general guidelines for how Esbriet should be used:

• Dosage: The typical dosage for Esbriet is 801 mg (three 267 mg capsules) taken orally three times a day, with food. The dosage may vary depending on individual patient factors, so it’s essential to follow the prescribing doctor’s instructions carefully.
• Administration: Esbriet capsules should be swallowed whole with plenty of water, and they should be taken with food to minimize gastrointestinal side effects.
• Adherence: It’s crucial to take Esbriet exactly as prescribed by the doctor, at the same times each day, to achieve the best therapeutic outcomes.
• Monitoring: Patients taking Esbriet will likely require regular monitoring by their healthcare provider to assess lung function and monitor for any potential side effects.
• Side effects: Common side effects of Esbriet may include nausea, diarrhea, rash, and fatigue. If these side effects become severe or persistent, it’s important to notify the prescribing doctor.
• Precautions: Before starting Esbriet, patients should inform their healthcare provider about any other medications they are taking, as well as any existing medical conditions. Esbriet may interact with certain medications or exacerbate certain health conditions.
• Pregnancy and breastfeeding: Esbriet may cause harm to a developing fetus, so it’s essential to use effective contraception during treatment and for some time afterward. Additionally, it’s not recommended to breastfeed while taking Esbriet, as it is not known whether the drug passes into breast milk.

It’s important for patients to discuss any questions or concerns about Esbriet with their healthcare provider to ensure safe and effective use of the medication.

Other uses for this medicine

While Esbriet (pirfenidone) is primarily prescribed for the treatment of idiopathic pulmonary fibrosis (IPF), it has also been investigated for potential use in other fibrotic conditions, such as systemic sclerosis-related interstitial lung disease (SSc-ILD) and fibrotic hypersensitivity pneumonitis. However, its effectiveness in these conditions is still being studied, and it’s not currently approved for these uses in many countries.

What special precautions should I follow?

Regarding special precautions for Esbriet use, here are some key points to consider:

• Allergies: Before taking Esbriet, patients should inform their healthcare provider about any known allergies, especially to pirfenidone or any other ingredients in the medication.
• Medical history: Patients should disclose their full medical history, including any liver problems, kidney problems, gastrointestinal disorders, or other significant health issues, to their healthcare provider before starting Esbriet.
• Pregnancy and breastfeeding: Esbriet may cause harm to a developing fetus, so it’s essential for women of childbearing potential to use effective contraception during treatment and for some time afterward. Additionally, it’s not recommended to breastfeed while taking Esbriet, as it is not known whether the drug passes into breast milk.
• Drug interactions: Patients should inform their healthcare provider about all medications, supplements, and herbal products they are currently taking, as Esbriet may interact with certain medications. It’s especially important to mention blood thinners (anticoagulants) and medications that affect liver function.
• Liver function monitoring: Esbriet may cause liver enzyme elevations in some patients. Healthcare providers may perform regular monitoring of liver function tests during Esbriet treatment to detect any abnormalities.
• Kidney function monitoring: Esbriet may also affect kidney function. Therefore, healthcare providers may monitor kidney function through regular testing during treatment.
• Side effects: Patients should be aware of potential side effects of Esbriet, such as nausea, diarrhea, rash, fatigue, and photosensitivity. If any side effects occur, they should promptly notify their healthcare provider.
• Dosage adjustments: Dosage adjustments may be necessary for patients with liver or kidney impairment. Healthcare providers will determine the appropriate dosage based on individual patient factors.
• Follow-up appointments: Patients should attend all follow-up appointments with their healthcare provider to monitor their response to treatment and assess for any potential complications.
• Storage: Esbriet should be stored at room temperature away from moisture and heat, and it should be kept out of reach of children.

Patients should always follow their healthcare provider’s instructions and recommendations for the safe and effective use of Esbriet.

What special dietary instructions should I follow?

There are no specific dietary restrictions associated with Esbriet. However, taking it with food can help minimize gastrointestinal side effects. Follow a balanced diet unless advised otherwise by your healthcare provider.

What should I do if I forget a dose?

If you forget to take a dose of Esbriet, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose and take your next dose at the scheduled time. Do not double the dose to catch up. If you’re unsure about what to do, contact your healthcare provider or pharmacist for guidance.

What side effects can this medication cause?

Esbriet (pirfenidone) may cause various side effects in some individuals. It’s important to note that not everyone will experience these side effects, and their severity can vary. Some common side effects of Esbriet include:

• Nausea: Feeling sick to the stomach or experiencing the urge to vomit.
• Diarrhea: Frequent bowel movements that are loose or watery.
• Fatigue: Feeling tired or lacking energy.
• Rash: Skin irritation or redness, which may or may not be accompanied by itching.
• Photosensitivity: Increased sensitivity to sunlight, which may cause sunburn more easily.
• Loss of appetite: A reduced desire to eat or a feeling of fullness even without eating much.
• Abdominal discomfort: Pain, cramping, or discomfort in the stomach area.
• Headache: Pain or discomfort in the head, which can vary in intensity.
• Dizziness: Feeling lightheaded or unsteady.
• Elevated liver enzymes: Changes in liver function tests, which may indicate liver problems in some individuals.
• Elevated bilirubin: Increased levels of bilirubin in the blood, which may also indicate liver issues.

It’s essential to report any side effects experienced while taking Esbriet to your healthcare provider promptly. They can provide guidance on managing these side effects and may adjust your treatment regimen if necessary. In some cases, discontinuation of Esbriet may be required if severe side effects occur.

Additionally, there may be other side effects not listed here. Patients should consult their healthcare provider or pharmacist for a comprehensive list of potential side effects associated with Esbriet.

What should I know about storage and disposal of this medication?

Regarding storage and disposal of Esbriet:

Storage:

• Store Esbriet at room temperature, preferably between 68°F to 77°F (20°C to 25°C).
• Keep the medication in its original container or packaging to protect it from moisture and light.
• Do not store Esbriet in the bathroom or any other area with high humidity or temperature fluctuations.
• Keep Esbriet out of reach of children and pets.
• Do not use Esbriet if it has passed the expiration date or if the packaging is damaged.

Disposal:

• Dispose of unused or expired Esbriet properly according to local regulations or guidelines.
• Do not flush Esbriet down the toilet or pour it down the drain unless instructed to do so by healthcare professionals or local authorities.
• Consult with your pharmacist or healthcare provider on the appropriate method of disposal.

In case of emergency/overdose

• In case of an overdose or emergency, call your local poison control center or emergency medical services immediately.
• If possible, provide them with information such as the amount of medication taken, the time it was ingested, and any symptoms experienced.
• Do not attempt to induce vomiting unless instructed by medical professionals.

What other information should I know?

• Keep all appointments with your healthcare provider for monitoring and follow-up.
• Inform all healthcare providers involved in your care, including dentists and specialists, that you’re taking Esbriet.
• Carry a list of all medications you’re currently taking, including prescription and over-the-counter drugs, as well as any allergies you may have.
• Avoid prolonged exposure to sunlight and ultraviolet (UV) light while taking Esbriet, as it may increase the risk of sunburn.
• Follow your healthcare provider’s instructions regarding dietary considerations, lifestyle modifications, and other aspects of your treatment plan.
• Report any new or worsening symptoms to your healthcare provider promptly.
• Do not share Esbriet with others, even if they have similar symptoms or conditions.

It’s crucial to follow these guidelines and any additional instructions provided by your healthcare provider to ensure the safe and effective use of Esbriet. If you have any questions or concerns about your medication, don’t hesitate to consult your healthcare provider or pharmacist for clarification.