WARNING

Erelzi is a medication used to treat autoimmune diseases like rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis. It is a biosimilar to Enbrel (etanercept), which means it has similar properties to Enbrel but is not an exact copy. Like any medication, Erelzi comes with potential risks and side effects. Some of the risks associated with taking Erelzi include:

• Infections: Erelzi can increase the risk of infections, including serious ones like tuberculosis and fungal infections. Patients taking Erelzi should be monitored for signs of infection, and they should not take it if they have an active infection.
• Injection site reactions: Common side effects of Erelzi include redness, swelling, itching, or pain at the injection site. These reactions are usually mild but can sometimes be severe.
• Allergic reactions: Some people may experience allergic reactions to Erelzi, which can be serious and require immediate medical attention. Symptoms may include difficulty breathing, swelling of the face, lips, tongue, or throat, and rash.
• Autoimmune reactions: Erelzi works by suppressing the immune system, which can lead to autoimmune reactions in some people. This may cause symptoms such as lupus-like syndrome or worsening of existing autoimmune diseases.
• Neurological events: Rarely, Erelzi can cause neurological events such as seizures, multiple sclerosis-like symptoms, or optic neuritis.
• Heart failure: Erelzi may increase the risk of congestive heart failure, especially in people with a history of heart problems.
• Blood disorders: Some patients may experience changes in blood cell counts while taking Erelzi, which can increase the risk of anemia, leukopenia, or thrombocytopenia.

It’s important for patients considering Erelzi to discuss the potential risks and benefits with their healthcare provider. They should also be monitored closely for any signs of adverse reactions while taking the medication.

Why is this medication prescribed?

Erelzi is prescribed primarily to treat autoimmune diseases that involve inflammation, particularly those conditions associated with overactivity of the immune system and excess production of a protein called tumor necrosis factor-alpha (TNF-alpha). It is used to manage conditions such as:

• Rheumatoid Arthritis (RA): Erelzi is indicated for reducing signs and symptoms, inhibiting the progression of structural damage, and improving physical function in adult patients with moderately to severely active rheumatoid arthritis.
• Psoriatic Arthritis (PsA): Erelzi is prescribed for treating active psoriatic arthritis, a type of arthritis that affects some people with psoriasis.
• Ankylosing Spondylitis (AS): Erelzi is used to reduce signs and symptoms in adult patients with active ankylosing spondylitis, a type of arthritis that primarily affects the spine.
• Plaque Psoriasis: Erelzi is indicated for the treatment of chronic moderate to severe plaque psoriasis in adults who are candidates for systemic therapy or phototherapy.

These conditions are all characterized by inflammation, joint pain, stiffness, and sometimes skin involvement (in the case of psoriasis). Erelzi works by targeting and neutralizing TNF-alpha, which is a pro-inflammatory cytokine involved in the immune response. By inhibiting TNF-alpha, Erelzi helps reduce inflammation, relieve symptoms, and slow down the progression of joint damage in these autoimmune diseases.

How should this medicine be used?

Erelzi is a brand name for the medication etanercept, which is a tumor necrosis factor (TNF) inhibitor. It is primarily used to treat autoimmune diseases such as rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, and plaque psoriasis.

Here are general guidelines for using Erelzi:

• Dosage: The dosage of Erelzi varies depending on the condition being treated and the severity of the disease. Your healthcare provider will determine the appropriate dosage for you.
• Administration: Erelzi is typically administered by subcutaneous injection. The injections can be self-administered or given by a healthcare professional. It’s important to follow the instructions provided by your healthcare provider for the correct administration technique.
• Frequency: The frequency of Erelzi injections also depends on the condition being treated. Typically, it is administered once or twice a week initially, and then the frequency may be adjusted based on your response to the medication.
• Storage: Erelzi should be stored in the refrigerator between 2°C to 8°C (36°F to 46°F). It should not be frozen. Before use, it can be left at room temperature for about 15 to 30 minutes to allow it to warm up slightly.
• Monitoring: While using Erelzi, your healthcare provider may monitor your condition regularly to assess the effectiveness of the medication and to check for any potential side effects.
• Adverse Reactions: Like all medications, Erelzi can cause side effects. Common side effects may include injection site reactions, upper respiratory infections, headache, and nausea. Serious side effects such as infections or allergic reactions are possible but less common. It’s important to report any unusual symptoms to your healthcare provider.
• Precautions: Before starting Erelzi, inform your healthcare provider about any other medications you are taking, including over-the-counter drugs and supplements. Also, inform them about any medical conditions you have, particularly if you have a history of infections or tuberculosis.
• Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss the risks and benefits of using Erelzi with your healthcare provider.

Always follow your healthcare provider’s instructions precisely when using Erelzi or any other medication. Do not adjust your dosage or frequency without consulting your healthcare provider first.

Other uses for this medicine

Regarding other uses for Erelzi, it’s primarily indicated for the treatment of autoimmune conditions such as rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, and plaque psoriasis. However, it may also be used off-label for other autoimmune or inflammatory conditions, but this should only be done under the supervision of a healthcare professional.

What special precautions should I follow?

As for special precautions to follow when taking Erelzi, it’s essential to adhere to the guidance provided by your healthcare provider. Here are some general precautions:

• Infections: Erelzi can increase the risk of infections, so it’s important to avoid close contact with individuals who have contagious illnesses. If you develop any signs of infection, such as fever, chills, cough, or sore throat, notify your healthcare provider promptly.
• Vaccinations: Before starting Erelzi, make sure you’re up-to-date on all recommended vaccinations. Avoid live vaccines while taking Erelzi, as they may pose a risk of infection.
• Monitoring: Your healthcare provider may monitor you closely while you’re taking Erelzi, including checking for signs of infection and monitoring your blood cell counts, liver function, and other relevant parameters.
• Allergic reactions: If you’ve had a previous allergic reaction to Erelzi or any of its components, make sure to inform your healthcare provider. Allergic reactions can be serious and require immediate medical attention.
• Pre-existing conditions: Inform your healthcare provider about any pre-existing medical conditions you have, especially if you have a history of heart problems, neurological disorders, or blood disorders.
• Pregnancy and breastfeeding: If you’re pregnant, planning to become pregnant, or breastfeeding, discuss the risks and benefits of Erelzi with your healthcare provider. The medication’s safety during pregnancy and breastfeeding is not well-established.
• Other medications: Inform your healthcare provider about all medications, supplements, and herbal products you’re taking, as they may interact with Erelzi.

Always follow your healthcare provider’s instructions regarding the use of Erelzi and report any concerns or side effects promptly.

What special dietary instructions should I follow?

Regarding special dietary instructions for Erelzi, there are typically no specific dietary restrictions associated with its use. However, maintaining a balanced and healthy diet is essential for overall well-being, especially if you’re managing a chronic condition like rheumatoid arthritis or psoriatic arthritis. Your healthcare provider may recommend dietary changes to support your treatment plan, such as reducing inflammation through an anti-inflammatory diet.

What should I do if I forget a dose?

If you forget a dose of Erelzi, take it as soon as you remember. However, if it’s almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. If you’re unsure about what to do, consult your healthcare provider or pharmacist for guidance.

What side effects can this medication cause?

Erelzi (etanercept) can cause various side effects, ranging from mild to severe. It’s essential to be aware of these potential side effects and discuss any concerns with your healthcare provider. Some common side effects of Erelzi include:

• Injection site reactions: Redness, swelling, itching, or pain at the injection site are common side effects. These reactions are usually mild and temporary.
• Upper respiratory infections: Erelzi may increase the risk of upper respiratory infections, such as the common cold or sinusitis.
• Headache: Headaches are a common side effect of Erelzi treatment.
• Nausea: Some people may experience nausea or stomach discomfort while taking Erelzi.
• Diarrhea: Diarrhea is another gastrointestinal side effect that may occur.
• Rash: Skin rash or irritation may occur as a side effect of Erelzi.
• Fatigue: Some individuals may experience fatigue or tiredness while taking Erelzi.
• Dizziness: Dizziness or lightheadedness may occur in some people.
• Elevated liver enzymes: Erelzi can sometimes affect liver function, leading to elevated liver enzymes.
• Serious infections: While less common, Erelzi can increase the risk of serious infections, including bacterial, fungal, and viral infections. These infections may require medical attention and can be life-threatening if not treated promptly.
• Allergic reactions: Allergic reactions to Erelzi, although rare, can occur. Symptoms may include difficulty breathing, swelling of the face, lips, tongue, or throat, and rash. Allergic reactions require immediate medical attention.
• Neurological events: Rarely, Erelzi can cause neurological events such as seizures, multiple sclerosis-like symptoms, or optic neuritis.
• Heart failure: Erelzi may increase the risk of congestive heart failure, especially in people with a history of heart problems.
• Blood disorders: Changes in blood cell counts, such as anemia, leukopenia, or thrombocytopenia, may occur in some individuals taking Erelzi.

It’s important to report any side effects you experience while taking Erelzi to your healthcare provider promptly. They can help determine whether the side effect requires further evaluation or if any adjustments to your treatment plan are necessary.

What should I know about storage and disposal of this medication?

Storage and Disposal:

• Storage: Erelzi should be stored in the refrigerator at a temperature between 36°F to 46°F (2°C to 8°C). Do not freeze. Keep the medication in its original carton to protect it from light. Do not use Erelzi if it has been frozen or exposed to extreme temperatures. If needed, Erelzi can be stored at room temperature (up to 77°F or 25°C) for up to 14 days. Once removed from the refrigerator, do not put it back.
• Disposal: Dispose of used Erelzi prefilled syringes or autoinjectors properly according to local regulations or guidelines provided by your healthcare provider or pharmacist. Do not dispose of them in household trash. Sharps containers may be available at pharmacies or healthcare facilities for safe disposal of needles and syringes.

In case of emergency/overdose

In case of an emergency or overdose involving Erelzi, seek immediate medical attention or contact your local poison control center. Symptoms of overdose may include severe headache, weakness, confusion, difficulty breathing, seizures, or loss of consciousness.

What other information should I know?

• Keep Erelzi and all medications out of the reach of children and pets.
• Do not share Erelzi with others, even if they have similar symptoms or conditions.
• Follow your healthcare provider’s instructions carefully regarding the dosage and administration of Erelzi.
• Inform all healthcare providers involved in your care (including dentists and surgeons) that you are taking Erelzi.
• Attend all scheduled appointments with your healthcare provider for monitoring and follow-up.
• Report any new or worsening symptoms, side effects, or concerns to your healthcare provider promptly.
• Inform your healthcare provider if you are planning to have surgery, as Erelzi may need to be temporarily discontinued.
• Keep a record of your injections, including the date, time, and injection site, to ensure proper administration and rotation of injection sites.
• Store Erelzi prefilled syringes or autoinjectors away from direct sunlight, heat, and moisture.
• Do not use Erelzi if the prefilled syringe or autoinjector appears damaged or if the liquid is discolored or contains particles.
• If you have any questions or concerns about Erelzi, consult your healthcare provider or pharmacist for guidance.