Why is this medication prescribed?

Erdafitinib is a medication used in the treatment of certain types of advanced or metastatic bladder cancer. It falls under the category of targeted therapy drugs, specifically as a fibroblast growth factor receptor (FGFR) inhibitor. FGFRs are proteins involved in the growth and spread of cancer cells, and inhibiting them can help slow down or stop cancer growth.

Erdafitinib is typically prescribed when the cancer has progressed despite previous treatments or when other treatment options are not suitable. It is specifically indicated for patients with locally advanced or metastatic urothelial carcinoma (cancer of the urinary bladder) with certain FGFR genetic alterations.

How should this medicine be used?

Erdafitinib is typically taken orally in the form of tablets. Here are general guidelines for how Erdafitinib should be used:

• Dosage: The dosage of Erdafitinib can vary depending on factors such as the patient’s weight, overall health, and specific cancer characteristics. The healthcare provider will determine the appropriate dosage for each individual patient.
• Administration: Erdafitinib tablets should be swallowed whole with water, and they can be taken with or without food. It’s important not to crush, chew, or break the tablets.
• Schedule: Erdafitinib is usually taken once daily, following the schedule recommended by the healthcare provider. It’s essential to adhere to the prescribed dosing schedule and not to miss any doses.
• Duration: Patients should continue taking Erdafitinib for as long as their healthcare provider recommends, even if they start to feel better. Stopping the medication prematurely could allow the cancer to progress.
• Monitoring: Patients prescribed Erdafitinib should be regularly monitored by their healthcare team for both effectiveness and potential side effects. This monitoring may include blood tests, imaging studies, and regular check-ups.
• Side Effects: It’s important for patients to be aware of potential side effects associated with Erdafitinib and to promptly report any new or worsening symptoms to their healthcare provider. Common side effects may include fatigue, diarrhea, nausea, vomiting, mouth sores, changes in appetite, and changes in liver function tests.
• Interactions: Patients should inform their healthcare provider about all medications, supplements, and herbal products they are taking, as Erdafitinib may interact with certain medications. This includes prescription drugs, over-the-counter medications, vitamins, and herbal supplements.
• Storage: Erdafitinib tablets should be stored at room temperature away from moisture and heat. They should be kept in their original packaging and out of reach of children.

It’s important for patients to follow the specific instructions provided by their healthcare provider regarding the use of Erdafitinib. Any questions or concerns about the medication should be discussed with the healthcare provider.

Other uses for this medicine

Erdafitinib is primarily indicated for the treatment of certain types of advanced or metastatic bladder cancer with specific FGFR genetic alterations. However, there may be ongoing research or clinical trials investigating its potential effectiveness in other types of cancers or conditions. Patients should consult with their healthcare provider for the most up-to-date information on alternative uses of Erdafitinib.

What special precautions should I follow?

Regarding special precautions for Erdafitinib, patients should consider the following:

• Pregnancy and breastfeeding: Erdafitinib may harm an unborn baby. Therefore, it is essential to inform the healthcare provider if you are pregnant or planning to become pregnant. Similarly, breastfeeding while taking Erdafitinib is not recommended as it may harm the infant.
• Liver function: Erdafitinib can affect liver function, so patients should undergo regular liver function tests while taking the medication. If there are significant changes in liver function tests or if signs of liver problems occur (such as yellowing of the skin or eyes, dark urine, abdominal pain), patients should inform their healthcare provider immediately.
• Eye problems: Erdafitinib has been associated with eye problems, including changes in vision, retinal detachment, and intraocular pressure elevation. Patients should inform their healthcare provider if they experience any visual disturbances while taking Erdafitinib.
• Drug interactions: Erdafitinib may interact with other medications, potentially affecting their effectiveness or increasing the risk of side effects. Patients should inform their healthcare provider about all medications, supplements, and herbal products they are taking before starting Erdafitinib.
• Allergic reactions: Some individuals may experience allergic reactions to Erdafitinib. Patients should seek immediate medical attention if they develop symptoms of an allergic reaction, such as rash, itching, swelling, dizziness, or difficulty breathing.
• Medical history: Patients should inform their healthcare provider about their medical history, especially if they have a history of liver problems, eye problems, or allergic reactions to medications.
• Driving and operating machinery: Erdafitinib may cause dizziness or blurred vision, which can impair the ability to drive or operate machinery safely. Patients should exercise caution when engaging in activities that require mental alertness or visual acuity.
• Storage: Erdafitinib tablets should be stored according to the manufacturer’s instructions, away from moisture and heat, and out of reach of children.

It’s important for patients to discuss any concerns or questions about Erdafitinib with their healthcare provider. They should also adhere to the prescribed dosage and follow-up appointments for monitoring while taking the medication.

What special dietary instructions should I follow?

Special Dietary Instructions:

• Grapefruit and grapefruit juice: Erdafitinib should not be taken with grapefruit or grapefruit juice, as it may increase the levels of Erdafitinib in your blood, leading to an increased risk of side effects.
• High-fat meals: While Erdafitinib can be taken with or without food, it’s advisable to avoid consuming high-fat meals shortly before or after taking the medication. High-fat meals may affect the absorption of Erdafitinib in the body.
• Stay hydrated: It’s important to stay well-hydrated while taking Erdafitinib, as it can help prevent certain side effects such as diarrhea and nausea. Drinking plenty of water throughout the day is recommended unless otherwise advised by your healthcare provider.

What should I do if I forget a dose?

• If it’s within 12 hours of the missed dose: Take the missed dose as soon as you remember. Then, continue with your regular dosing schedule.
• If it’s more than 12 hours since the missed dose: Skip the missed dose and take the next dose at your regular scheduled time. Do not double the dose to make up for the missed one.
• Notify your healthcare provider: If you frequently forget doses or if you’re unsure about what to do, it’s essential to contact your healthcare provider for guidance.

What side effects can this medication cause?

Erdafitinib, like any medication, can cause side effects. It’s important to note that not all individuals will experience these side effects, and the severity can vary from person to person. Common side effects associated with Erdafitinib include:

• Fatigue: Feeling tired or weak is a common side effect of Erdafitinib.
• Diarrhea: Diarrhea is another common side effect that may occur while taking Erdafitinib. It’s important to stay hydrated if you experience diarrhea.
• Nausea and vomiting: Some individuals may experience nausea and vomiting while taking Erdafitinib.
• Mouth sores: Soreness or ulcers in the mouth can occur as a side effect of Erdafitinib.
• Changes in liver function tests: Erdafitinib may affect liver function, leading to changes in liver function tests. Your healthcare provider will monitor your liver function regularly.
• Changes in kidney function tests: Erdafitinib can also affect kidney function, leading to changes in kidney function tests. Regular monitoring is essential.
• Eye problems: Some individuals may experience changes in vision, including blurred vision or visual disturbances, while taking Erdafitinib. In some cases, more severe eye problems such as retinal detachment or increased intraocular pressure may occur.
• High phosphate levels: Erdafitinib may cause an increase in phosphate levels in the blood, which can lead to symptoms such as muscle cramps, joint pain, or weakness.
• Skin reactions: Skin rash, itching, or dry skin may occur as a side effect of Erdafitinib.
• Hair loss: Some individuals may experience hair loss while taking Erdafitinib.

It’s essential to discuss any side effects you experience with your healthcare provider. They can provide guidance on managing side effects and may adjust your treatment plan if necessary. Additionally, contact your healthcare provider immediately if you experience any severe or concerning side effects while taking Erdafitinib.

What should I know about storage and disposal of this medication?

Storage and Disposal:

• Storage: Erdafitinib tablets should be stored at room temperature, away from moisture and heat. Keep the medication in its original packaging and out of reach of children.
• Disposal: Unused or expired Erdafitinib tablets should be disposed of properly. Do not flush them down the toilet or pour them down the drain unless instructed to do so. Instead, consult your healthcare provider or local pharmacy for guidance on the proper disposal method.

In case of emergency/overdose

In case of an emergency or suspected overdose of Erdafitinib, seek immediate medical attention or contact your local poison control center. You can also call emergency services such as 911. Be prepared to provide information about the medication ingested, the dosage, and any symptoms experienced.

What other information should I know?

• Follow-up appointments: Regular follow-up appointments with your healthcare provider are essential while taking Erdafitinib. These appointments allow for monitoring of your condition, assessment of treatment effectiveness, and management of any side effects or complications.
• Lab tests: Your healthcare provider may order regular blood tests and other laboratory tests to monitor your liver function, kidney function, and overall health while taking Erdafitinib.
• Avoid grapefruit: Avoid consuming grapefruit or grapefruit juice while taking Erdafitinib, as it may interact with the medication and increase the risk of side effects.
• Inform healthcare providers: Make sure to inform all healthcare providers involved in your care, including dentists and pharmacists, that you are taking Erdafitinib. This helps ensure coordinated care and prevents potential interactions with other medications or treatments.
• Pregnancy and breastfeeding: Erdafitinib may harm an unborn baby, so it’s essential to use effective birth control during treatment and to avoid becoming pregnant. Additionally, Erdafitinib may pass into breast milk, so breastfeeding is not recommended while taking this medication.
• Driving and operating machinery: Erdafitinib may cause dizziness or blurred vision, which can impair your ability to drive or operate machinery safely. Use caution until you know how Erdafitinib affects you.

Always consult your healthcare provider or pharmacist if you have any questions or concerns about Erdafitinib or its usage. They can provide personalized guidance based on your specific medical history and circumstances.