Why is this medication prescribed?

Enspryng (satralizumab) is prescribed for the treatment of neuromyelitis optica spectrum disorder (NMOSD) in adults and children aged 12 years and older. NMOSD is a rare autoimmune disorder that affects the optic nerves and spinal cord, leading to inflammation and damage.

Satralizumab works by targeting and blocking interleukin-6 (IL-6) receptors, which are involved in the inflammatory process implicated in NMOSD. By blocking IL-6 receptors, Enspryng helps to reduce inflammation and the frequency of relapses associated with NMOSD.

How should this medicine be used?

Enspryng (satralizumab) is typically used for the treatment of neuromyelitis optica spectrum disorder (NMOSD). It’s important to use Enspryng exactly as prescribed by your healthcare provider. Here are general guidelines for how Enspryng is typically used:

• Administration: Enspryng is administered as a subcutaneous injection, which means it is injected under the skin. It is usually given by a healthcare professional initially to ensure proper technique. If self-administration is appropriate, your healthcare provider will provide training on how to administer the injections yourself.
• Dosage: The dosage of Enspryng may vary depending on factors such as your weight, medical condition, and response to treatment. Typically, the initial loading dose is given as two injections two weeks apart. Following the loading dose, maintenance doses are administered every four weeks thereafter.
• Injection Sites: Enspryng injections are usually administered into the thigh, abdomen, or outer area of the upper arm. Your healthcare provider will provide guidance on rotating injection sites to minimize discomfort and potential injection site reactions.
• Storage: Enspryng should be stored in the refrigerator at a temperature of 2°C to 8°C (36°F to 46°F). Do not freeze Enspryng. Before administration, allow the medication to reach room temperature by leaving it out of the refrigerator for about 30 minutes.
• Preparation: Before administering the injection, ensure that you have all necessary supplies including the Enspryng prefilled syringe, alcohol wipes, and a sharps disposal container. Wash your hands thoroughly with soap and water. Clean the injection site with an alcohol wipe and allow it to dry completely.
• Injection Technique: Follow the instructions provided by your healthcare provider for proper injection technique. Hold the syringe firmly and insert the needle into the skin at a 45- to 90-degree angle, depending on the injection site. Inject the medication slowly and steadily, and then remove the needle. Do not rub the injection site after administration.
• Disposal: Safely dispose of used needles and syringes in a puncture-resistant container designated for sharps disposal. Do not reuse needles or syringes.
• Follow-Up: Attend all scheduled appointments with your healthcare provider for monitoring of your condition and response to treatment.

Always consult your healthcare provider if you have any questions or concerns about the use of Enspryng. They can provide personalized guidance based on your individual needs and circumstances.

Other uses for this medicine

Enspryng (satralizumab) is primarily indicated for the treatment of neuromyelitis optica spectrum disorder (NMOSD). However, as with many medications, there may be off-label or investigational uses that are being explored beyond its approved indication. It’s important to note that the off-label use of Enspryng should only be done under the guidance and supervision of a healthcare professional.

What special precautions should I follow?

Regarding special precautions for Enspryng, here are some important points to consider:

• Allergies: Inform your healthcare provider if you have any known allergies to satralizumab or any other ingredients in Enspryng. Allergic reactions can occur and may require immediate medical attention.
• Infections: Enspryng can increase the risk of infections. Before starting treatment, make sure to inform your healthcare provider if you have a history of chronic or recurrent infections. Additionally, it’s important to promptly report any signs or symptoms of infection, such as fever, cough, or sore throat, to your healthcare provider.
• Vaccinations: Discuss with your healthcare provider whether it is safe to receive vaccinations while taking Enspryng. Live vaccines should generally be avoided due to the risk of infection.
• Liver Function: Enspryng may affect liver function. Your healthcare provider may monitor your liver function with blood tests before and during treatment.
• Pregnancy and Breastfeeding: It is essential to inform your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding. The potential risks and benefits of Enspryng during pregnancy and breastfeeding should be discussed with your healthcare provider.
• Immunosuppression: Enspryng may suppress the immune system, which can increase the risk of certain conditions or infections. Your healthcare provider may monitor your immune function and adjust treatment accordingly.
• Interactions: Inform your healthcare provider about all medications, supplements, and herbal products you are taking, as they may interact with Enspryng.
• Storage: Store Enspryng prefilled syringes in the refrigerator at a temperature of 2°C to 8°C (36°F to 46°F). Do not freeze Enspryng. Keep it out of the reach of children.

Always follow your healthcare provider’s instructions and guidance regarding the use of Enspryng and any special precautions that may apply to your individual situation. If you have any questions or concerns, do not hesitate to discuss them with your healthcare provider.

What special dietary instructions should I follow?

Regarding special dietary instructions for Enspryng, there are no specific dietary restrictions associated with its use. However, maintaining a balanced and nutritious diet can support overall health and may complement your treatment plan. If you have any concerns or questions about your diet while taking Enspryng, consult your healthcare provider or a registered dietitian for personalized advice.

What should I do if I forget a dose?

If you forget to take a dose of Enspryng, take it as soon as you remember. If it is close to the time of your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you have questions about missed doses or need guidance, contact your healthcare provider or pharmacist for advice tailored to your situation.

What side effects can this medication cause?

Enspryng (satralizumab) can cause side effects, although not everyone will experience them. Some common side effects may include:

• Injection site reactions: This can include redness, swelling, pain, or itching at the injection site. These reactions are usually mild to moderate in severity.
• Upper respiratory tract infections: Symptoms may include cough, sore throat, runny nose, and congestion.
• Headache: Some people may experience headaches while taking Enspryng.
• Nasopharyngitis: This refers to inflammation of the nasal passages and throat, leading to symptoms such as congestion, runny nose, and sore throat.
• Nausea: Some individuals may experience feelings of nausea or gastrointestinal discomfort.
• Arthralgia: This refers to joint pain, which may occur as a side effect of Enspryng.
• Fatigue: Some people may experience increased fatigue or tiredness.
• Rash: Skin rash or itching may occur in some individuals.
• Urinary tract infection: Symptoms may include painful urination, frequent urination, or urgency to urinate.
• Elevations in liver enzymes: Enspryng may cause increases in liver enzymes, which can be detected through blood tests.

It’s essential to report any side effects to your healthcare provider, even if they seem mild, as they can provide guidance on managing side effects or adjusting your treatment if necessary. Additionally, seek medical attention if you experience any severe or concerning side effects while taking Enspryng.

This list does not include all possible side effects of Enspryng. If you have specific concerns about side effects or require further information, consult your healthcare provider or pharmacist. They can provide personalized advice based on your medical history and individual circumstances.

What should I know about storage and disposal of this medication?

Storage and disposal of Enspryng:

• Storage:
  • Store Enspryng prefilled syringes in the refrigerator at a temperature of 2°C to 8°C (36°F to 46°F).
  • Do not freeze Enspryng.
  • Keep Enspryng out of the reach of children and pets.
  • Do not use Enspryng if it has been frozen or if the expiration date has passed.
• Disposal:
  • Safely dispose of used needles and syringes in a puncture-resistant container designated for sharps disposal.
  • Do not reuse needles or syringes.
  • Follow any local regulations or guidelines for the disposal of Enspryng prefilled syringes.

In case of emergency/overdose

• In case of an overdose or emergency, such as an allergic reaction, contact emergency medical services immediately.
• If possible, provide the healthcare provider with information about the medication, dosage, and any other relevant details.
• If someone has accidentally injected too much Enspryng, seek medical attention promptly.

What other information should I know?

• Keep all appointments with your healthcare provider for monitoring of your condition and response to treatment.
• Inform your healthcare provider about all medications, supplements, and herbal products you are taking, as they may interact with Enspryng.
• Attend regular follow-up appointments for blood tests or other monitoring as recommended by your healthcare provider.
• Be aware of the signs and symptoms of infection and report them promptly to your healthcare provider.
• If you are pregnant, planning to become pregnant, or breastfeeding, discuss the risks and benefits of Enspryng with your healthcare provider.
• Inform any other healthcare providers or emergency responders that you are taking Enspryng if you require medical treatment or procedures.

It’s essential to follow your healthcare provider’s instructions and guidelines for the safe and effective use of Enspryng. If you have any questions or concerns about storage, disposal, emergency procedures, or other aspects of Enspryng treatment, consult your healthcare provider or pharmacist for personalized advice.