Why is this medication prescribed?

Emgality (generic name: galcanezumab) is a medication primarily prescribed for the prevention of migraines in adults. Migraines are intense headaches that can be debilitating, often accompanied by symptoms such as nausea, vomiting, and sensitivity to light and sound. Emgality belongs to a class of medications called calcitonin gene-related peptide (CGRP) inhibitors, which work by blocking the activity of CGRP, a molecule involved in the transmission of pain signals during migraines.

How should this medicine be used?

Emgality is typically administered as a subcutaneous injection, meaning it is injected under the skin. The usual recommended dose is 120 mg once monthly, but some patients may benefit from a higher dose of 240 mg once monthly, which involves two consecutive injections of 120 mg each. It’s important for patients to follow the dosage instructions provided by their healthcare provider.

Here’s how Emgality should be used:

• Preparation: Before administering the injection, it’s important to wash hands thoroughly with soap and water. The injection site should also be cleaned with an alcohol wipe and allowed to dry.
• Administration: Emgality is injected into the fatty tissue just under the skin (subcutaneously). The common injection sites include the abdomen, thigh, or upper arm. The injection should not be given in areas where the skin is tender, bruised, red, or hard.
• Injection Technique: The injection can be self-administered or given by a caregiver. If self-administering, patients should follow the instructions provided in the Emgality package insert or by their healthcare provider. The injection technique involves pinching a fold of skin and injecting the medication at a 45 to 90-degree angle. After injection, the needle should be withdrawn, and pressure can be applied to the injection site with a cotton ball or gauze.
• Disposal: Used needles and syringes should be disposed of properly in a puncture-resistant container according to local regulations. This helps prevent accidental needle sticks and reduces the risk of infection.

It’s essential for patients to receive proper training from their healthcare provider on how to administer Emgality correctly. Additionally, patients should not change the dosage or frequency of administration without consulting their healthcare provider. If there are any concerns or questions about using Emgality, it’s important to discuss them with a healthcare professional.

Other uses for this medicine

While Emgality (galcanezumab) is primarily prescribed for the prevention of migraines, there have been studies exploring its potential use in other conditions. Some research suggests that CGRP inhibitors like Emgality may also be effective in treating other headache disorders such as cluster headaches and tension-type headaches. However, these uses are still being investigated, and Emgality is not currently approved for these indications.

What special precautions should I follow?

Special precautions should be taken when using Emgality. Here are some important considerations:

• Allergies: Before using Emgality, patients should inform their healthcare provider about any allergies they have, especially if they are allergic to galcanezumab or any other ingredients in the medication. Allergic reactions to Emgality can include rash, itching, swelling, severe dizziness, or trouble breathing.
• Pregnancy and Breastfeeding: The safety of Emgality during pregnancy and breastfeeding is not well established. Pregnant or breastfeeding individuals should discuss the potential risks and benefits of using Emgality with their healthcare provider before starting treatment.
• Liver and Kidney Function: Emgality is primarily metabolized and eliminated by the liver, so individuals with impaired liver function may require dose adjustments or closer monitoring. Similarly, patients with significant kidney impairment may also need dosage modifications.
• Immunosuppression: Patients receiving immunosuppressive therapy or who have a weakened immune system may be at increased risk of infections while using Emgality. It’s important to discuss any existing medical conditions or medications with a healthcare provider before starting treatment.
• Injection Site Reactions: Injection site reactions such as redness, swelling, or pain may occur with the use of Emgality. Patients should rotate injection sites and report any persistent or severe reactions to their healthcare provider.
• Driving and Operating Machinery: Emgality may cause dizziness or fatigue in some individuals. Patients should exercise caution when driving or operating machinery until they know how Emgality affects them.
• Interactions with Other Medications: It’s important to inform healthcare providers about all medications, vitamins, and supplements being taken, as they may interact with Emgality.

As with any medication, it’s crucial to follow the healthcare provider’s instructions regarding the use of Emgality and to report any concerning symptoms or side effects promptly.

What special dietary instructions should I follow?

Regarding special dietary instructions for Emgality, there are no specific dietary restrictions associated with its use. However, maintaining a healthy diet and lifestyle can contribute to overall well-being and may complement the management of migraine symptoms.

What should I do if I forget a dose?

If you forget a dose of Emgality, administer it as soon as you remember. Then, resume your regular dosing schedule. If it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up. If you are unsure about what to do, consult your healthcare provider or pharmacist for guidance.

What side effects can this medication cause?

Like all medications, Emgality (galcanezumab) may cause side effects in some individuals. Common side effects of Emgality include:

• Injection Site Reactions: Pain, redness, or swelling at the injection site are common.
• Allergic Reactions: Some people may experience allergic reactions to Emgality, which can include rash, itching, swelling (especially of the face, tongue, or throat), severe dizziness, or trouble breathing. Seek immediate medical attention if you experience any signs of an allergic reaction.
• Headache: It’s possible to experience headache as a side effect of Emgality, although this may be less common compared to its primary use in migraine prevention.
• Nausea: Some individuals may experience nausea as a side effect of Emgality.
• Fatigue: Feeling tired or fatigued is another possible side effect.
• Upper Respiratory Tract Infections: Some people may experience symptoms of upper respiratory tract infections, such as the common cold, while using Emgality.
• Muscle Pain: Muscle pain or stiffness may occur as a side effect.
• Dizziness: Feeling dizzy or lightheaded is possible with Emgality use.

It’s important to note that not everyone will experience these side effects, and some individuals may experience side effects not listed here. If you experience any concerning or persistent side effects while using Emgality, it’s essential to inform your healthcare provider. They can provide guidance on managing side effects and determine if any adjustments to your treatment plan are necessary.

What should I know about storage and disposal of this medication?

Storage and disposal of Emgality:

• Storage: Emgality should be stored in the refrigerator at a temperature between 36°F to 46°F (2°C to 8°C). Do not freeze. Keep the medication in its original carton to protect it from light. Once removed from the refrigerator, Emgality can be stored at room temperature (up to 77°F or 25°C) for up to 7 days. If not used within 7 days, discard any remaining medication.
• Disposal: Used needles and syringes should be disposed of properly in a puncture-resistant container according to local regulations. This helps prevent accidental needle sticks and reduces the risk of infection. Do not reuse needles or syringes. Unused or expired Emgality should be disposed of in accordance with local regulations for medication disposal.

In case of emergency/overdose

In case of emergency or overdose of Emgality, seek immediate medical attention or contact a poison control center. Symptoms of overdose may include severe headache, dizziness, nausea, vomiting, or allergic reactions. It’s essential to follow the guidance of healthcare professionals in managing any overdose situation.

What other information should I know?

• Effectiveness: Emgality is most effective when used as prescribed by your healthcare provider. It may take some time before you notice the full benefits of the medication in preventing migraines.
• Monitoring: Your healthcare provider may monitor your response to Emgality and adjust your treatment plan accordingly. Be sure to attend all scheduled appointments and communicate any changes or concerns regarding your migraine symptoms.
• Medication Interactions: Inform your healthcare provider about all medications, vitamins, and supplements you are taking, as they may interact with Emgality. This includes both prescription and over-the-counter medications.
• Travel: If you need to travel with Emgality, it’s important to store the medication properly and ensure that it remains within the recommended temperature range. Consider bringing a travel cooler if necessary.
• Patient Support: Some pharmaceutical companies offer patient support programs for individuals prescribed Emgality. These programs may provide assistance with insurance coverage, access to medication, or educational resources. You can inquire with your healthcare provider or the manufacturer of Emgality for more information about available support programs.

As always, if you have any questions or concerns about using Emgality, don’t hesitate to discuss them with your healthcare provider or pharmacist. They can provide personalized guidance based on your individual needs and circumstances.