WARNING

Elzonris (tagraxofusp) is a medication used to treat a rare blood disorder called blastic plasmacytoid dendritic cell neoplasm (BPDCN), which typically affects the bone marrow and blood. Like all medications, Elzonris carries certain risks. Some potential risks and side effects of taking Elzonris may include:

• Capillary Leak Syndrome: This is a serious condition where fluid and proteins leak out of tiny blood vessels into surrounding tissues, leading to swelling, low blood pressure, and potential organ damage.
• Liver Toxicity: Elzonris can cause liver problems, which may manifest as elevated liver enzymes or more serious conditions such as liver failure.
• Fluid Retention: Some patients may experience fluid retention, leading to swelling in various parts of the body.
• Hemorrhage: Elzonris can increase the risk of bleeding, which may be serious in some cases.
• Increased Susceptibility to Infections: Elzonris can suppress the immune system, making patients more vulnerable to infections.
• Fatigue: Fatigue is a common side effect of Elzonris treatment.
• Gastrointestinal Symptoms: Nausea, vomiting, diarrhea, and abdominal pain are potential gastrointestinal side effects of Elzonris.
• Electrolyte Imbalance: Elzonris may cause electrolyte abnormalities, which can affect various bodily functions.

It’s important for patients taking Elzonris to be closely monitored by their healthcare provider for any signs of these potential side effects. Additionally, patients should discuss any concerns or questions with their healthcare team before starting treatment with Elzonris.

Why is this medication prescribed?

Elzonris (tagraxofusp-erzs) is prescribed for the treatment of blastic plasmacytoid dendritic cell neoplasm (BPDCN) in adults and pediatric patients, typically in cases where the disease has returned (relapsed) or is not responding to other treatments (refractory). BPDCN is a rare and aggressive type of blood cancer that often affects the bone marrow, blood, and skin.

Elzonris is a targeted therapy that works by binding to CD123, a protein found on the surface of certain cancer cells, and delivering a toxic protein directly to these cells, which can help to destroy them.

How should this medicine be used?

The dosage and administration of Elzonris typically involve an intravenous (IV) infusion over a specified period of time. The specific dosage and schedule will be determined by the healthcare provider based on factors such as the patient’s weight, overall health, and response to treatment.

It’s important for patients to receive Elzonris under the supervision of a healthcare professional experienced in administering chemotherapy or other cancer treatments. Additionally, patients should adhere to the treatment schedule recommended by their healthcare provider and follow any instructions provided for managing potential side effects.

As with any medication, patients should discuss any questions or concerns about Elzonris with their healthcare provider before starting treatment.

Other uses for this medicine

Elzonris (tagraxofusp-erzs) is specifically approved for the treatment of blastic plasmacytoid dendritic cell neoplasm (BPDCN) and is not indicated for other uses. It is a targeted therapy that works by binding to CD123, a protein found on the surface of certain cancer cells, and delivering a toxic protein directly to these cells to help destroy them.

What special precautions should I follow?

As for special precautions, patients should follow the guidance provided by their healthcare provider closely. Some general precautions for taking Elzonris may include:

• Regular Monitoring: Patients may need to undergo regular blood tests and other monitoring to check for potential side effects and assess the effectiveness of treatment.
• Precautions for Capillary Leak Syndrome: Capillary Leak Syndrome is a potentially serious side effect of Elzonris. Patients should be monitored closely for symptoms such as swelling, low blood pressure, and difficulty breathing. If these symptoms occur, patients should seek medical attention promptly.
• Infections: Elzonris can suppress the immune system, increasing the risk of infections. Patients should take precautions to avoid exposure to infections and notify their healthcare provider if they develop signs of an infection, such as fever or persistent cough.
• Liver Function: Elzonris may cause liver toxicity. Patients should undergo regular liver function tests to monitor for any signs of liver damage.
• Pregnancy and Breastfeeding: Elzonris may harm an unborn baby, so it is important for pregnant women to avoid using this medication. Women of childbearing age should use effective contraception during treatment with Elzonris. It is not known whether Elzonris passes into breast milk, so breastfeeding is not recommended during treatment.
• Interactions with Other Medications: Patients should inform their healthcare provider about all medications, supplements, and herbal products they are taking, as some medications may interact with Elzonris.
• Allergic Reactions: Some patients may experience allergic reactions to Elzonris. Patients should seek medical attention immediately if they develop symptoms such as rash, itching, difficulty breathing, or swelling of the face, lips, or tongue.

These are general precautions, and patients should discuss any specific concerns or questions with their healthcare provider before starting treatment with Elzonris.

What special dietary instructions should I follow?

Regarding special dietary instructions for Elzonris, there are no specific dietary restrictions associated with this medication. However, maintaining a balanced and nutritious diet is generally recommended to support overall health and well-being during cancer treatment.

What should I do if I forget a dose?

If you forget a dose of Elzonris, contact your healthcare provider or treatment team immediately for guidance. They will provide instructions on whether to take the missed dose or adjust your treatment schedule accordingly. It’s crucial not to double up on doses unless specifically instructed by your healthcare provider to avoid potential overdose or complications.

What side effects can this medication cause?

Elzonris (tagraxofusp-erzs) can cause several side effects, some of which may be serious. It’s important to note that not all individuals will experience these side effects, and the severity can vary from person to person. Common side effects of Elzonris may include:

• Capillary Leak Syndrome (CLS): This is a potentially serious condition where fluid and proteins leak out of tiny blood vessels into surrounding tissues, leading to swelling, low blood pressure, and potential organ damage.
• Liver Toxicity: Elzonris can cause liver problems, which may manifest as elevated liver enzymes or more serious conditions such as liver failure.
• Fluid Retention: Some patients may experience fluid retention, leading to swelling in various parts of the body.
• Hemorrhage: Elzonris can increase the risk of bleeding, which may be serious in some cases.
• Increased Susceptibility to Infections: Elzonris can suppress the immune system, making patients more vulnerable to infections.
• Fatigue: Fatigue is a common side effect of Elzonris treatment.
• Gastrointestinal Symptoms: Nausea, vomiting, diarrhea, and abdominal pain are potential gastrointestinal side effects of Elzonris.
• Electrolyte Imbalance: Elzonris may cause electrolyte abnormalities, which can affect various bodily functions.

Other less common but potentially serious side effects may include allergic reactions, including rash, itching, difficulty breathing, or swelling of the face, lips, or tongue. Additionally, some patients may experience infusion-related reactions during or shortly after receiving Elzonris.

It’s essential for patients to discuss any concerns or questions about potential side effects with their healthcare provider before starting treatment with Elzonris. Healthcare providers will monitor patients closely for side effects and provide guidance on managing them effectively.

What should I know about storage and disposal of this medication?

Storage and disposal instructions for Elzonris:

• Storage: Elzonris should be stored at the recommended temperature as indicated on the product packaging or by your healthcare provider. It should be kept in its original packaging and protected from light. Do not freeze Elzonris. Keep it out of the reach of children and pets.
• Disposal: Unused or expired Elzonris should be disposed of properly according to local regulations. Check with your healthcare provider or pharmacist for guidance on how to dispose of the medication safely. Do not dispose of Elzonris by pouring it down the drain or flushing it down the toilet unless instructed to do so.

In case of emergency/overdose

In case of emergency or overdose of Elzonris, it is important to seek immediate medical attention. Contact your healthcare provider, local emergency services, or go to the nearest emergency room right away. Be sure to bring the medication packaging or container with you to provide information to healthcare professionals.

What other information should I know?

• Follow-up appointments: Your healthcare provider will schedule regular follow-up appointments to monitor your progress, assess any side effects, and adjust your treatment plan as needed.
• Medication interactions: Inform your healthcare provider about all medications, supplements, and herbal products you are taking, as they may interact with Elzonris.
• Infusion administration: Elzonris is administered through intravenous (IV) infusion by a healthcare professional in a medical setting, such as a hospital or clinic.
• Patient support: Your healthcare provider or treatment center may offer support services and resources to help you manage your condition and treatment effectively.
• Symptom management: If you experience any side effects or symptoms while taking Elzonris, notify your healthcare provider promptly. They can provide guidance on managing side effects and may adjust your treatment regimen if necessary.

Always follow your healthcare provider’s instructions and guidance regarding the use of Elzonris and any other medications or treatments. If you have any questions or concerns, do not hesitate to discuss them with your healthcare provider.