WARNING

Dulaglutide injection is a medication used to treat type 2 diabetes. Like any medication, it carries certain risks. Some potential risks of taking dulaglutide injection include:

• Hypoglycemia: This is when blood sugar levels drop too low. It can cause symptoms like shakiness, dizziness, confusion, and in severe cases, loss of consciousness.
• Pancreatitis: In some cases, dulaglutide can cause inflammation of the pancreas, leading to pancreatitis. Symptoms include severe abdominal pain, nausea, and vomiting.
• Kidney problems: There have been reports of kidney problems, including worsening kidney function or kidney failure, in people taking dulaglutide.
• Thyroid tumors: Studies in animals have shown an increased risk of thyroid tumors with dulaglutide, although it’s unclear if this risk translates to humans.
• Allergic reactions: Some people may experience allergic reactions to dulaglutide, which can cause symptoms such as rash, itching, difficulty breathing, or swelling of the face, lips, tongue, or throat.

It’s essential to discuss the potential risks and benefits of dulaglutide with your healthcare provider before starting treatment, and to report any unusual symptoms or side effects promptly.

Why is this medication prescribed?

Dulaglutide injection is prescribed primarily for the management of type 2 diabetes. It is used to help control blood sugar levels in adults with type 2 diabetes mellitus, particularly when diet and exercise alone are not sufficient to achieve glycemic control.

The medication works by mimicking the action of a hormone called glucagon-like peptide-1 (GLP-1), which helps regulate blood sugar levels by stimulating insulin release, slowing down digestion, and reducing the liver’s production of glucose. By targeting multiple aspects of glucose metabolism, dulaglutide can help improve glycemic control and may also lead to weight loss in some individuals.

Overall, dulaglutide is prescribed to help people with type 2 diabetes manage their condition effectively and reduce the risk of complications associated with uncontrolled blood sugar levels, such as heart disease, kidney problems, and nerve damage.

How should this medicine be used?

Dulaglutide injection is typically used according to the following guidelines:

• Dosage: The typical starting dose of dulaglutide is 0.75 mg injected once weekly. Your healthcare provider may adjust the dose based on your response to treatment and other factors.
• Administration: Dulaglutide is injected subcutaneously (under the skin) in the abdomen, thigh, or upper arm. You should rotate injection sites to prevent skin irritation.
• Timing: It’s usually injected on the same day each week, at any time of the day, with or without food.
• Follow-up: Regular monitoring by your healthcare provider is important to assess your response to treatment and adjust the dosage if needed.
• Lifestyle: Dulaglutide is often prescribed as part of a comprehensive treatment plan for type 2 diabetes, which may include diet, exercise, and other medications. It’s essential to follow your healthcare provider’s recommendations for diet and exercise while taking dulaglutide.

Always follow your healthcare provider’s instructions and read the medication guide provided with dulaglutide injection. If you have any questions or concerns about how to use it, don’t hesitate to ask your healthcare provider or pharmacist.

Other uses for this medicine

Dulaglutide injection is primarily used for the management of type 2 diabetes. However, it’s essential to note that healthcare providers may sometimes prescribe medications for off-label uses, meaning uses not approved by regulatory agencies such as the FDA. Such uses should be based on clinical judgment and evidence-based practices.

What special precautions should I follow?

As for special precautions when using dulaglutide injection:

• Hypoglycemia: Dulaglutide can lower blood sugar levels, which may lead to hypoglycemia (low blood sugar). Patients should be educated about the signs and symptoms of hypoglycemia and how to treat it, including having a fast-acting source of glucose readily available.
• Pancreatitis: There have been reports of pancreatitis (inflammation of the pancreas) with the use of dulaglutide. Patients should be monitored for signs and symptoms of pancreatitis, such as severe abdominal pain, nausea, and vomiting. If pancreatitis is suspected, dulaglutide should be discontinued.
• Thyroid tumors: Studies in animals have shown an increased risk of thyroid tumors with dulaglutide. Although it’s unclear if this risk translates to humans, patients with a history of thyroid cancer or those at risk for thyroid tumors should use dulaglutide with caution.
• Kidney function: Dulaglutide may affect kidney function, and patients with pre-existing kidney problems may require dose adjustments or closer monitoring while taking this medication.
• Allergic reactions: Some patients may experience allergic reactions to dulaglutide, including rash, itching, difficulty breathing, or swelling of the face, lips, tongue, or throat. Patients should seek medical attention immediately if they experience any signs of an allergic reaction.
• Gastrointestinal effects: Dulaglutide may cause gastrointestinal side effects such as nausea, vomiting, diarrhea, and constipation. Patients should be advised on strategies to manage these symptoms, such as dietary modifications and staying hydrated.
• Pregnancy and breastfeeding: The safety of dulaglutide during pregnancy and breastfeeding is not well-established. Pregnant or breastfeeding individuals should discuss the potential risks and benefits of dulaglutide with their healthcare provider before using the medication.

It’s crucial for patients to communicate openly with their healthcare providers about their medical history, current medications, and any concerns or side effects experienced while taking dulaglutide. This helps ensure safe and effective use of the medication.

What special dietary instructions should I follow?

Special Dietary Instructions for Dulaglutide Injection:

• • While there are no specific dietary restrictions associated with dulaglutide, it’s essential to maintain a healthy diet as recommended by your healthcare provider or dietitian.
  • Focus on a balanced diet rich in fruits, vegetables, whole grains, lean proteins, and healthy fats.
  • Monitor your carbohydrate intake and aim to spread it evenly throughout the day to help manage blood sugar levels.
  • Limit your intake of sugary foods and beverages, processed foods, and high-fat meals.
  • Stay hydrated by drinking plenty of water throughout the day.

What should I do if I forget a dose?

• If you forget to take a dose of dulaglutide, administer it as soon as you remember, unless it’s almost time for your next scheduled dose. In that case, skip the missed dose and continue with your regular dosing schedule.
• Do not take a double dose to make up for a missed one.
• If you’re unsure about what to do, contact your healthcare provider or pharmacist for guidance.

What side effects can this medication cause?

Dulaglutide injection, like any medication, can cause side effects. Common side effects may include:

• Nausea and vomiting: Some people may experience nausea, which may lead to vomiting, especially when starting treatment with dulaglutide. These symptoms often improve over time.
• Diarrhea or constipation: Changes in bowel habits, such as diarrhea or constipation, can occur with dulaglutide use.
• Abdominal pain: Some individuals may experience abdominal discomfort or pain while taking dulaglutide.
• Injection site reactions: Redness, swelling, or itching at the injection site are common side effects of dulaglutide injection. Rotating injection sites and using proper injection technique can help minimize these reactions.
• Hypoglycemia: Dulaglutide can lower blood sugar levels, which may lead to hypoglycemia (low blood sugar). Symptoms of hypoglycemia include shakiness, dizziness, sweating, confusion, and hunger.
• Pancreatitis: Although rare, dulaglutide has been associated with pancreatitis (inflammation of the pancreas). Symptoms include severe abdominal pain, nausea, and vomiting.
• Thyroid tumors: Studies in animals have shown an increased risk of thyroid tumors with dulaglutide. While it’s unclear if this risk translates to humans, individuals should be aware of any changes in the thyroid gland and report them to their healthcare provider.
• Allergic reactions: In rare cases, dulaglutide can cause allergic reactions, which may include rash, itching, difficulty breathing, or swelling of the face, lips, tongue, or throat. Seek medical attention immediately if you experience signs of an allergic reaction.
• Kidney problems: There have been reports of kidney problems, including worsening kidney function or kidney failure, in people taking dulaglutide.

It’s essential to report any side effects or unusual symptoms experienced while taking dulaglutide to your healthcare provider. They can provide guidance on managing side effects and may adjust your treatment if necessary.

What should I know about storage and disposal of this medication?

Regarding storage and disposal of Dulaglutide Injection:

• Storage: Store Dulaglutide Injection in the refrigerator between 36°F to 46°F (2°C to 8°C). Do not freeze. Keep the medication in the original carton to protect it from light. Once a pen is in use, it can be stored at room temperature (up to 86°F or 30°C) for up to 14 days.
• Do not freeze: Do not freeze Dulaglutide Injection. Freezing can damage the medication and make it ineffective.
• Disposal: Dispose of used needles and syringes in a puncture-resistant container. Follow local regulations or guidelines for the proper disposal of medical waste.

In case of emergency/overdose

• Seek medical attention: If you or someone else may have overdosed on Dulaglutide Injection, call your local emergency services or go to the nearest emergency room immediately.
• Symptom management: Depending on the symptoms, healthcare professionals may provide supportive care to manage any adverse effects of overdose, such as monitoring blood sugar levels and treating hypoglycemia if it occurs.

What other information should I know?

• Follow-up: Attend all scheduled appointments with your healthcare provider for monitoring of your diabetes and response to treatment.
• Medication reminders: Establish a routine for taking Dulaglutide Injection to help ensure consistency and effectiveness of treatment.
• Blood sugar monitoring: Continue monitoring your blood sugar levels as directed by your healthcare provider, even while taking Dulaglutide Injection.
• Lifestyle habits: Maintain a healthy lifestyle by following a balanced diet, engaging in regular physical activity, managing stress, and avoiding tobacco and excessive alcohol consumption.
• Interactions: Inform your healthcare provider about all medications, supplements, and herbal products you are taking, as they may interact with Dulaglutide Injection.
• Traveling: Plan ahead for travel to ensure you have an adequate supply of Dulaglutide Injection and necessary supplies, such as needles and syringes, especially if traveling across time zones.

Always follow your healthcare provider’s instructions and read the medication guide provided with Dulaglutide Injection for comprehensive information on its use, storage, and disposal. If you have any questions or concerns, don’t hesitate to consult your healthcare provider or pharmacist.