Why is this medication prescribed?

Dinoprostone, a synthetic form of prostaglandin E2 (PGE2), is prescribed for various medical purposes, primarily related to pregnancy and childbirth. Dinoprostone is commonly used to induce labor in pregnant women at term or near term when there is a medical need to deliver the baby. It helps to ripen (soften and dilate) the cervix and stimulate uterine contractions.

How should this medicine be used?

Dinoprostone comes as a vaginal insert and as a gel that is inserted high into the vagina. It is administered using a syringe, by a health professional in a hospital or clinic setting. After the dose has been administered you should remain lying down for up to 2 hours as directed by your physician. A second dose of the gel may be administered in 6 hours if the first dose does not produce the desired response.

Other uses for this medicine

In addition to its primary uses in obstetrics and gynecology, Dinoprostone has a few other applications:

• Therapeutic Abortion: Beyond the second trimester, Dinoprostone can be used as part of a regimen to induce abortion.
• Cervical Ripening for Hysteroscopy: In some cases, Dinoprostone is used to soften the cervix before procedures like hysteroscopy.
• Inducing Labor in Specific Medical Conditions: It can be used to induce labor in cases where continuing the pregnancy poses a risk to the mother or baby, such as preeclampsia, diabetes, or Rh incompatibility.

What special precautions should I follow?

Special precautions should be observed when using Dinoprostone:

• Medical Supervision: Dinoprostone should only be administered under the supervision of qualified medical personnel in a hospital setting.
• Fetal Monitoring: Continuous fetal monitoring is essential during Dinoprostone administration to ensure the safety of the fetus.
• Uterine Hyperstimulation: There’s a risk of uterine hyperstimulation (excessive uterine contractions), which can compromise fetal oxygenation. Close monitoring for signs of hyperstimulation is crucial.
• Previous Cesarean Section: Caution is advised when using Dinoprostone in women with a history of cesarean section due to the risk of uterine rupture.
• Allergic Reactions: Patients with a known hypersensitivity to Dinoprostone or any of its components should not receive the medication.
• Other Medical Conditions: Inform your healthcare provider about any other medical conditions you have, as well as any medications you are currently taking, to avoid potential interactions or complications.

Always follow your healthcare provider’s instructions and ask any questions you have about Dinoprostone or your treatment plan. They can provide personalized guidance based on your specific medical history and needs.

What special dietary instructions should I follow?

There are generally no specific dietary restrictions or instructions that need to be followed when using Dinoprostone. However, it is always a good idea to maintain a balanced diet and stay hydrated. If your healthcare provider gives any specific dietary advice related to your condition or treatment, be sure to follow it.

What should I do if I forget a dose?

• Contact Your Healthcare Provider: Inform your healthcare provider or nurse about the missed dose. They will provide guidance on what to do next based on your specific situation.
• Do Not Double Up: Do not take an extra dose to make up for the missed dose unless specifically instructed by your healthcare provider.
• Follow Instructions: Adhere to any instructions given by your healthcare provider regarding the missed dose and any adjustments to your dosing schedule.

What side effects can this medication cause?

Dinoprostone is a medication used to induce labor or to terminate pregnancy. Like any medication, it can cause side effects. Common side effects of dinoprostone include:

• Uterine contractions: Since dinoprostone stimulates uterine contractions, it can cause discomfort, cramping, or pain.
• Nausea and vomiting: Some individuals may experience nausea or vomiting while using dinoprostone.
• Diarrhea: Diarrhea can occur as a side effect of dinoprostone use.
• Fever: A low-grade fever may develop in some people after using dinoprostone.
• Headache: Headaches are another possible side effect.
• Fetal distress: Dinoprostone can occasionally cause fetal distress, which may necessitate intervention.
• Allergic reactions: Although rare, allergic reactions to dinoprostone can occur, presenting as rash, itching, swelling, or difficulty breathing.

It’s important to discuss any concerns or potential side effects with your healthcare provider before using dinoprostone or any other medication. They can provide guidance and monitor your response to the medication closely.

What should I know about storage and disposal of this medication?

Storage and Disposal of Dinoprostone:

• Storage: Store dinoprostone as directed by your healthcare provider or pharmacist. It is typically stored at room temperature away from moisture and heat. Avoid freezing. Keep it out of reach of children and pets.
• Disposal: Dispose of unused dinoprostone according to local regulations or as instructed by your healthcare provider or pharmacist. Do not flush it down the toilet unless instructed to do so. Proper disposal helps prevent environmental contamination and accidental ingestion.

In case of emergency/overdose

• Seek Medical Assistance: If you suspect an overdose or experience severe side effects, seek immediate medical attention by calling emergency services or visiting the nearest emergency room.
• Symptom Management: While waiting for medical help, follow any instructions provided by your healthcare provider or poison control center. If possible, provide information about the amount of dinoprostone ingested and the time of ingestion.

What other information should I know?

• Follow Instructions Carefully: Always use dinoprostone as directed by your healthcare provider. Do not exceed the recommended dosage or frequency of administration.
• Regular Monitoring: During dinoprostone treatment, you will be closely monitored by healthcare professionals for any adverse effects or signs of progress.
• Medical History: Inform your healthcare provider about any medical conditions you have, especially asthma, glaucoma, heart, liver, or kidney disease, as well as any allergies you may have.
• Interactions: Inform your healthcare provider about all medications, supplements, and herbal products you are currently taking, as dinoprostone may interact with certain medications.
• Follow-up Appointments: Attend all follow-up appointments with your healthcare provider to monitor your condition and ensure the effectiveness and safety of the treatment.
• Pregnancy and Breastfeeding: If you are pregnant or breastfeeding, discuss the risks and benefits of using dinoprostone with your healthcare provider before starting treatment.
• Be Informed: Educate yourself about dinoprostone, including its purpose, administration, potential side effects, and what to do in case of complications.

By following these guidelines and staying informed, you can safely use dinoprostone as prescribed by your healthcare provider. If you have any concerns or questions about its use, don’t hesitate to consult your healthcare provider for clarification and guidance.