WARNING

DHE-45 injection, which contains dihydroergotamine, is primarily used to treat migraines and cluster headaches. However, like any medication, it carries risks. Here’s a brief overview:

• Cardiovascular Risks: DHE-45 can cause vasoconstriction (narrowing of blood vessels), which may lead to increased blood pressure and potential cardiovascular events like heart attack or stroke, especially in individuals with pre-existing cardiovascular conditions.
• Peripheral Ischemia: Vasoconstriction can also affect blood flow to extremities, potentially causing peripheral ischemia, which can manifest as cold or numb fingers or toes.
• Serotonin Syndrome: DHE-45 interacts with serotonin receptors and may lead to serotonin syndrome, a potentially life-threatening condition characterized by symptoms like confusion, agitation, rapid heartbeat, and high blood pressure.
• Drug Interactions: DHE-45 can interact with other medications, particularly those that affect blood pressure or serotonin levels, increasing the risk of adverse effects or reducing effectiveness.
• Rebound Headaches: Prolonged use of DHE-45 can lead to rebound headaches, where the medication itself triggers more frequent or severe headaches when discontinued.
• Pregnancy Risks: DHE-45 is not recommended during pregnancy as it may cause fetal harm.
• Other Side Effects: Common side effects of DHE-45 injection include nausea, vomiting, dizziness, and injection site reactions.

It’s crucial to discuss these risks with a healthcare professional before starting DHE-45 treatment and to use the medication exactly as prescribed to minimize potential adverse effects.

Why is this medication prescribed?

DHE-45 injection, containing dihydroergotamine, is typically prescribed for the treatment of migraines and cluster headaches. Here’s why it’s prescribed and how it should be used:

• Migraines: DHE-45 is often prescribed for the acute treatment of migraines, especially when other medications such as NSAIDs or triptans are ineffective or contraindicated.
• Cluster Headaches: It’s also used to treat cluster headaches, which are severe headaches occurring in cyclical patterns, often several times a day for weeks or months.

How should this medicine be used?

DHE-45 Injection should be used exactly as prescribed by a healthcare professional. Here’s a general guideline for its use:

• Administration: DHE-45 is typically administered via intravenous (IV) infusion or intramuscular (IM) injection. It can also be given subcutaneously, depending on the formulation.
• Dosage: The dosage of DHE-45 varies depending on the condition being treated, the severity of symptoms, and individual patient response. It’s usually administered as a single dose at the onset of a migraine or cluster headache attack.
• Frequency: DHE-45 should not be used more frequently than prescribed to avoid the risk of rebound headaches.
• Caution with Self-Administration: DHE-45 injection should be administered by a healthcare professional in a clinical setting due to the potential for serious side effects, such as cardiovascular events.
• Follow-Up: Patients should be monitored closely during and after administration for any adverse reactions, especially cardiovascular symptoms.
• Other Treatments: DHE-45 may be used in conjunction with other migraine or cluster headache treatments as part of a comprehensive management plan.

It’s essential to follow the instructions provided by the healthcare provider carefully and to discuss any concerns or questions about DHE-45 treatment with them.

Other uses for this medicine

Regarding other uses, DHE-45 Injection is sometimes used off-label for certain other conditions, but this should only be done under the supervision of a healthcare professional. Off-label use means using the medication for a purpose other than what it is approved for by regulatory agencies. Some potential off-label uses may include:

• Treatment of certain types of vascular headaches.
• Management of acute attacks of hypertension.

What special precautions should I follow?

Special Precautions for DHE-45 Injection:

• Cardiovascular Precautions: DHE-45 can cause vasoconstriction and increase blood pressure, so it should be used with caution in individuals with cardiovascular disease, hypertension, or peripheral vascular disease.
• Liver and Kidney Function: DHE-45 is metabolized in the liver and excreted by the kidneys, so individuals with impaired liver or kidney function may require dosage adjustments or closer monitoring.
• Pregnancy and Breastfeeding: DHE-45 should be used with caution during pregnancy, as it may cause fetal harm. It’s not recommended for use during breastfeeding.
• Drug Interactions: DHE-45 can interact with other medications, including potent CYP3A4 inhibitors such as certain antibiotics and antifungal medications. It’s essential to inform your healthcare provider about all medications you’re taking before starting DHE-45 treatment.
• Serotonin Syndrome: DHE-45 interacts with serotonin receptors and may increase the risk of serotonin syndrome, particularly when used with other serotonergic medications. Symptoms include confusion, agitation, rapid heartbeat, and high blood pressure.
• Rebound Headaches: Prolonged use of DHE-45 can lead to rebound headaches, so it should be used sparingly and according to a healthcare provider’s instructions to minimize this risk.
• Allergic Reactions: Individuals with a known allergy to ergot alkaloids should not use DHE-45.

Always follow your healthcare provider’s instructions and discuss any concerns or questions you have about DHE-45 injection before starting treatment.

What special dietary instructions should I follow?

There are no specific dietary instructions associated with DHE-45 injection. However, maintaining a balanced and healthy diet can contribute to overall well-being and may indirectly support your treatment plan.

What should I do if I forget a dose?

If you forget a dose of DHE-45 injection, contact your healthcare provider or pharmacist for guidance. They can advise you on whether to take the missed dose when you remember or if you should skip it and continue with your regular dosing schedule. Do not double up on doses to make up for a missed one unless instructed to do so by your healthcare provider.

What side effects can this medication cause?

DHE-45 injection (dihydroergotamine) can cause various side effects, ranging from mild to severe. Here are some potential side effects to be aware of:

• Nausea and Vomiting: These are common side effects of DHE-45 injection.
• Dizziness: Some individuals may experience dizziness after receiving DHE-45.
• Injection Site Reactions: Pain, redness, or irritation at the injection site can occur.
• Transient Leg Cramps: Some people may experience transient leg cramps after DHE-45 injection.
• Peripheral Ischemia: Vasoconstriction caused by DHE-45 can lead to reduced blood flow to the extremities, resulting in symptoms such as cold or numb fingers or toes.
• Serotonin Syndrome: Although rare, DHE-45 can interact with serotonin receptors and may increase the risk of serotonin syndrome, characterized by symptoms like confusion, agitation, rapid heartbeat, and high blood pressure.
• Cardiovascular Effects: DHE-45 can cause vasoconstriction, which may lead to increased blood pressure and potential cardiovascular events such as heart attack or stroke, especially in individuals with pre-existing cardiovascular conditions.
• Allergic Reactions: Some individuals may experience allergic reactions to DHE-45, which can manifest as rash, itching, swelling, or difficulty breathing.
• Rebound Headaches: Prolonged use of DHE-45 can lead to rebound headaches when the medication is discontinued, resulting in more frequent or severe headaches.
• Other: Other potential side effects include weakness, fatigue, flushing, and transient changes in blood pressure.

It’s essential to report any side effects experienced while using DHE-45 injection to your healthcare provider. They can provide guidance on managing side effects and determine if any adjustments to your treatment plan are necessary. Additionally, seek medical attention immediately if you experience severe or concerning side effects.

What should I know about storage and disposal of this medication?

Storage and Disposal:

• Storage: Store DHE-45 injection vials at room temperature away from light and moisture. Do not freeze. Follow any specific storage instructions provided by your healthcare provider or pharmacist.
• Disposal: Dispose of unused or expired DHE-45 injection vials according to local regulations or guidelines. Do not dispose of medications in wastewater or household waste unless instructed to do so. Ask your pharmacist how to properly dispose of unused medications.

In case of emergency/overdose

• In Case of Emergency: If you experience severe or concerning side effects after using DHE-45 injection, seek medical attention immediately. Call emergency services or go to the nearest emergency room.
• Overdose: Symptoms of DHE-45 overdose may include severe dizziness, confusion, hallucinations, seizures, or difficulty breathing. If you suspect an overdose, seek immediate medical help. Do not attempt to treat an overdose on your own.

What other information should I know?

• Follow Instructions: Always use DHE-45 injection as directed by your healthcare provider. Do not change the dosage or frequency of use without consulting them first.
• Keep Appointments: Attend all scheduled appointments with your healthcare provider for monitoring and evaluation of your condition while using DHE-45 injection.
• Inform Healthcare Providers: Make sure to inform all healthcare providers involved in your care, including dentists and specialists, that you are using DHE-45 injection. They need to be aware of all medications you are taking to avoid potential interactions or complications.
• Avoid Alcohol: Limit or avoid alcohol consumption while using DHE-45 injection, as it may exacerbate certain side effects such as dizziness or drowsiness.
• Driving and Operating Machinery: DHE-45 injection may cause dizziness or drowsiness. Avoid driving or operating heavy machinery until you know how this medication affects you.
• Medical Alert: Consider wearing a medical alert bracelet or carrying a medical alert card indicating that you are using DHE-45 injection, especially if you have a history of severe migraines or cluster headaches.

Always consult your healthcare provider or pharmacist if you have any questions or concerns about the use of DHE-45 injection, including storage, disposal, emergencies, or other important information. They can provide personalized guidance based on your medical history and individual needs.