WARNING

Desvenlafaxine, commonly known as Pristiq, is an antidepressant medication used to treat major depressive disorder. Like all medications, it carries certain risks and potential side effects. Here are some of the risks associated with taking Desvenlafaxine:

• Side Effects: Common side effects include nausea, dizziness, insomnia, dry mouth, constipation, and sweating. These side effects are usually mild and may improve over time.
• Serotonin Syndrome: Desvenlafaxine can increase serotonin levels in the brain, and in rare cases, this can lead to a condition called serotonin syndrome. Symptoms may include confusion, hallucinations, rapid heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea. Severe cases can be life-threatening and require immediate medical attention.
• Withdrawal Symptoms: Suddenly stopping Desvenlafaxine can lead to withdrawal symptoms such as dizziness, nausea, headache, irritability, insomnia, fatigue, tingling sensations, and electric shock-like sensations. It’s important to gradually taper off the medication under medical supervision to minimize withdrawal effects.
• Suicidal Thoughts: Like other antidepressants, Desvenlafaxine may increase the risk of suicidal thoughts or behavior, especially in young adults, children, and adolescents. Close monitoring by a healthcare professional is crucial, especially when starting the medication or adjusting the dosage.
• Increased Blood Pressure: Desvenlafaxine may raise blood pressure, particularly at higher doses. Patients with preexisting hypertension should be closely monitored while taking this medication.
• Other Precautions: Desvenlafaxine should be used cautiously in patients with a history of seizures, bipolar disorder, liver or kidney problems, and those taking other medications that can interact with it.

It’s important for individuals considering Desvenlafaxine to discuss the potential risks and benefits with their healthcare provider, who can provide personalized guidance based on their medical history and individual circumstances.

Why is this medication prescribed?

Desvenlafaxine is typically prescribed for the treatment of major depressive disorder (MDD), a mood disorder characterized by persistent feelings of sadness, loss of interest or pleasure in activities, changes in appetite or weight, difficulty sleeping or oversleeping, energy loss, feelings of worthlessness or guilt, difficulty concentrating, and in severe cases, thoughts of death or suicide.

It belongs to a class of medications called serotonin-norepinephrine reuptake inhibitors (SNRIs), which work by increasing the levels of serotonin and norepinephrine, two neurotransmitters in the brain associated with mood regulation.

How should this medicine be used?

Desvenlafaxine is typically taken orally in the form of an extended-release tablet, once daily. Here are some general guidelines on how Desvenlafaxine should be used:

• Dosage: The dosage of Desvenlafaxine varies depending on the individual’s condition, response to treatment, and other factors. It’s usually started at a low dose and gradually increased over time, as determined by a healthcare professional. The maximum recommended dose is 400 milligrams per day, although most individuals are prescribed lower doses.
• Timing: Desvenlafaxine can be taken with or without food. It’s essential to take it at the same time each day to maintain consistent levels of the medication in the bloodstream and to help establish a routine.
• Swallowing: Swallow the extended-release tablet whole with water. Do not crush, chew, or break the tablet, as this can interfere with the extended-release mechanism and may lead to too much medication being released at once.
• Duration: Continue taking Desvenlafaxine even if you start feeling better unless instructed otherwise by your healthcare provider. Suddenly stopping the medication can lead to withdrawal symptoms, so it’s important to follow your healthcare provider’s guidance on when and how to discontinue its use.
• Monitoring: Your healthcare provider may need to monitor your progress regularly while you are taking Desvenlafaxine. This may involve periodic check-ups, blood tests, or other assessments to ensure the medication is working effectively and to monitor for any potential side effects or complications.
• Missed Doses: If you miss a dose of Desvenlafaxine, take it as soon as you remember, unless it is close to the time of your next scheduled dose. In that case, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
• Storage: Store Desvenlafaxine at room temperature away from light and moisture. Keep it out of reach of children and pets.

It’s crucial to follow your healthcare provider’s instructions and dosage recommendations precisely when taking Desvenlafaxine. If you have any questions or concerns about how to use this medication, don’t hesitate to discuss them with your healthcare provider or pharmacist for personalized guidance and advice.

Other uses for this medicine

As for other uses, desvenlafaxine may also be prescribed off-label for conditions such as generalized anxiety disorder, social anxiety disorder, and panic disorder. However, its effectiveness for these conditions may vary, and it’s essential to consult with a healthcare professional for proper diagnosis and treatment.

What special precautions should I follow?

As with any medication, it’s important to take special precautions when using Desvenlafaxine. Here are some key precautions to keep in mind:

• Medical History: Inform your healthcare provider about any medical conditions you have, including allergies, bipolar disorder, glaucoma, high blood pressure, liver or kidney problems, seizures, and history of drug abuse or suicidal thoughts.
• Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss the potential risks and benefits of Desvenlafaxine with your healthcare provider. The medication may pose risks to the fetus or newborn, and alternatives may need to be considered.
• Interactions: Desvenlafaxine can interact with certain medications, including monoamine oxidase inhibitors (MAOIs), linezolid, methylene blue, other SNRIs, SSRIs, tricyclic antidepressants, triptans, tramadol, St. John’s wort, and certain drugs that affect blood clotting. Inform your healthcare provider about all the medications, supplements, and herbal products you are currently taking to avoid potential interactions.
• Suicidal Thoughts: Desvenlafaxine, like other antidepressants, may increase the risk of suicidal thoughts or behavior, especially in young adults, children, and adolescents. Close monitoring by a healthcare professional is crucial, especially when starting the medication or adjusting the dosage.
• Alcohol and Other Substances: Avoid consuming alcohol while taking Desvenlafaxine, as it may increase the risk of side effects such as dizziness or drowsiness. Also, be cautious when using other substances that can affect mood or cognition.

Always follow your healthcare provider’s instructions and guidance when using Desvenlafaxine or any other medication to ensure safe and effective treatment. If you have any questions or concerns about Desvenlafaxine or its use, don’t hesitate to discuss them with your healthcare provider.

What special dietary instructions should I follow?

Regarding special dietary instructions, there are no specific dietary restrictions associated with Desvenlafaxine. However, it’s essential to maintain a balanced diet and avoid excessive alcohol consumption, as alcohol can interact with the medication and increase the risk of side effects.

What should I do if I forget a dose?

If you forget a dose of Desvenlafaxine, take it as soon as you remember, unless it is close to the time of your next scheduled dose. In that case, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up. If you are unsure about what to do, consult your healthcare provider or pharmacist for guidance.

What side effects can this medication cause?

Desvenlafaxine, like any medication, can cause side effects. Common side effects of Desvenlafaxine include:

• Nausea: Feeling sick to your stomach, which may be temporary and improve over time.
• Dizziness: Feeling lightheaded or unsteady, especially when standing up quickly.
• Insomnia: Difficulty falling asleep or staying asleep.
• Dry Mouth: Feeling thirsty due to reduced saliva production.
• Constipation: Difficulty passing stools, which may cause discomfort.
• Sweating: Increased sweating, particularly during sleep or physical activity.
• Fatigue: Feeling tired or lacking energy.
• Decreased Appetite: Reduced desire to eat, which may lead to weight loss.
• Anxiety: Feeling nervous, restless, or on edge.
• Headache: Mild to moderate head pain, which may occur especially at the beginning of treatment.
• Sexual Side Effects: Changes in libido, erectile dysfunction, or difficulty achieving orgasm.
• Tremor: Involuntary shaking of hands or other parts of the body.
• Increased Blood Pressure: Desvenlafaxine can sometimes raise blood pressure, particularly at higher doses.
• Serotonin Syndrome: Though rare, an excessive increase in serotonin levels in the body can lead to symptoms such as confusion, hallucinations, rapid heart rate, fever, sweating, shivering, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea.

It’s essential to note that not everyone will experience these side effects, and some individuals may experience different or more severe side effects. If you experience any side effects while taking Desvenlafaxine, it’s essential to discuss them with your healthcare provider. They can provide guidance on managing side effects or adjusting your treatment regimen if necessary. Additionally, if you experience severe or concerning side effects such as chest pain, difficulty breathing, or suicidal thoughts, seek medical attention immediately.

What should I know about storage and disposal of this medication?

Storage and Disposal:

• Storage: Store Desvenlafaxine at room temperature away from light and moisture. Keep it in its original packaging, and make sure it’s out of reach of children and pets.
• Disposal: If you no longer need Desvenlafaxine or it has expired, it’s essential to dispose of it properly. Do not flush it down the toilet or pour it down the drain unless instructed to do so. Instead, check with your pharmacist or local waste disposal company for guidance on how to dispose of medication safely. Some communities offer drug take-back programs or provide specific instructions for medication disposal.

In case of emergency/overdose

• Seek Medical Help: In case of an overdose or if you suspect someone has taken too much Desvenlafaxine, seek medical attention immediately by calling emergency services or a poison control center. Do not wait for symptoms to develop before seeking help.
• Symptoms of Overdose: Symptoms of Desvenlafaxine overdose may include dizziness, drowsiness, nausea, vomiting, rapid heart rate, seizures, confusion, hallucinations, and loss of consciousness. Prompt medical treatment is necessary to address these symptoms and prevent complications.

What other information should I know?

• Follow Instructions: Always follow your healthcare provider’s instructions and dosage recommendations precisely when taking Desvenlafaxine. Do not change your dose or stop taking the medication without consulting your healthcare provider first.
• Regular Monitoring: Your healthcare provider may need to monitor your progress regularly while you are taking Desvenlafaxine. This may involve periodic check-ups, blood tests, or other assessments to ensure the medication is working effectively and to monitor for any potential side effects or complications.
• Avoid Alcohol: It’s important to avoid consuming alcohol while taking Desvenlafaxine, as it may increase the risk of side effects such as dizziness or drowsiness.
• Inform Healthcare Providers: Make sure to inform all healthcare providers involved in your care, including doctors, dentists, and pharmacists, that you are taking Desvenlafaxine. This will help them make informed decisions about your treatment and avoid potential drug interactions.
• Be Patient: It may take several weeks for Desvenlafaxine to start working fully. Continue taking the medication as directed by your healthcare provider, even if you do not notice immediate improvements in your symptoms.
• Suicidal Thoughts: Desvenlafaxine, like other antidepressants, may increase the risk of suicidal thoughts or behavior, especially in young adults, children, and adolescents. Close monitoring by a healthcare professional is crucial, especially when starting the medication or adjusting the dosage.

Always keep Desvenlafaxine and all medications out of reach of children and pets, and never share your medication with others. If you have any questions or concerns about Desvenlafaxine or its use, don’t hesitate to discuss them with your healthcare provider or pharmacist for personalized guidance and advice.