WARNING

Daurismo (glasdegib) is a medication used to treat acute myeloid leukemia (AML). Like any medication, it carries certain risks and side effects. Some of the potential risks of taking Daurismo include:

• Bone marrow suppression: Daurismo can lower the production of blood cells in the bone marrow, leading to an increased risk of anemia, bleeding, and infections.
• Liver problems: It may cause liver toxicity or damage, leading to symptoms such as jaundice (yellowing of the skin and eyes), abdominal pain, and elevated liver enzymes.
• Muscle toxicity: Rarely, Daurismo can cause muscle problems such as muscle pain, weakness, and elevated levels of creatine kinase in the blood.
• Heart problems: There is a risk of heart-related side effects, including QT interval prolongation, which can lead to abnormal heart rhythms and potentially life-threatening complications.
• Drug interactions: Daurismo may interact with other medications, potentially increasing the risk of side effects or reducing the effectiveness of either medication.
• Birth defects: Daurismo can cause harm to a developing fetus, so it is not recommended for use during pregnancy. Women of childbearing age should use effective contraception while taking this medication.

It’s essential for patients taking Daurismo to be closely monitored by their healthcare provider for any signs of side effects or complications. Always discuss the risks and benefits of any medication with your doctor before starting treatment.

Why is this medication prescribed?

Daurismo (glasdegib) is prescribed for the treatment of newly diagnosed acute myeloid leukemia (AML) in adult patients who are not candidates for intensive chemotherapy. AML is a type of cancer that affects the blood and bone marrow, and Daurismo works by inhibiting a protein called smoothened, which is involved in the growth and survival of cancer cells.

How should this medicine be used?

As for how Daurismo should be used, it’s typically taken orally, in tablet form. The recommended dosage and duration of treatment will be determined by the healthcare provider based on factors such as the patient’s age, overall health, and the specific characteristics of their leukemia.

Here are some general guidelines for using Daurismo:

• Dosage: The usual dose of Daurismo is one tablet (100 mg) taken orally once daily. It’s important to follow the dosage instructions provided by your doctor.
• Administration: Daurismo tablets should be swallowed whole with water and can be taken with or without food.
• Duration of treatment: Treatment with Daurismo is usually continued until disease progression or unacceptable toxicity occurs, as determined by the healthcare provider.
• Monitoring: During treatment with Daurismo, patients will need regular monitoring, including blood tests to check for any potential side effects or complications.
• Interactions: Daurismo may interact with other medications, so it’s essential to inform your doctor about all the medications, supplements, or herbal products you are taking before starting treatment with Daurismo.
• Pregnancy and contraception: Daurismo can cause harm to a developing fetus, so it’s important to use effective contraception during treatment and avoid becoming pregnant. If you are pregnant or planning to become pregnant, discuss the risks and benefits of Daurismo with your doctor.

Always follow your healthcare provider’s instructions carefully when taking Daurismo, and do not adjust your dosage or stop taking the medication without consulting your doctor first.

Other uses for this medicine

• Daurismo is primarily indicated for the treatment of newly diagnosed AML in combination with low-dose cytarabine.
• It’s important to note that Daurismo is not approved for use in children.

What special precautions should I follow?

Regarding special precautions for taking Daurismo, here are some important points to consider:

• Pregnancy and contraception: Daurismo can cause harm to a developing fetus, so it’s important for women of childbearing age to use effective contraception during treatment and avoid becoming pregnant. If you are pregnant or planning to become pregnant, discuss the risks and benefits of Daurismo with your doctor.
• Liver function: Daurismo can cause liver toxicity or damage, so it’s essential to monitor liver function through blood tests before starting treatment and regularly during treatment. Inform your doctor if you experience symptoms such as jaundice (yellowing of the skin and eyes) or abdominal pain, as these may indicate liver problems.
• Muscle toxicity: While rare, Daurismo can cause muscle problems such as muscle pain, weakness, and elevated levels of creatine kinase in the blood. Report any unusual muscle symptoms to your healthcare provider.
• Heart health: Daurismo may prolong the QT interval, which can lead to abnormal heart rhythms. Patients with a history of heart problems or those taking other medications that can prolong the QT interval may require closer monitoring.
• Drug interactions: Daurismo may interact with other medications, including certain antiarrhythmics, antifungals, and antibiotics. Inform your doctor about all the medications, supplements, or herbal products you are taking before starting treatment with Daurismo.
• Bone marrow suppression: Daurismo can lower the production of blood cells in the bone marrow, leading to an increased risk of anemia, bleeding, and infections. Regular blood tests will be necessary to monitor blood cell counts during treatment.

Always follow your healthcare provider’s instructions and guidance when taking Daurismo, and don’t hesitate to discuss any concerns or questions you may have about the medication or its potential side effects.

What special dietary instructions should I follow?

Regarding special dietary instructions for Daurismo, there are no specific dietary restrictions associated with this medication. However, it’s always advisable to maintain a healthy, balanced diet to support overall well-being during cancer treatment. If you have any concerns about diet and nutrition while taking Daurismo, consult your healthcare provider or a registered dietitian for personalized advice.

What should I do if I forget a dose?

If you forget to take a dose of Daurismo, take it as soon as you remember, unless it’s almost time for your next scheduled dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you have any questions or concerns about missed doses, contact your healthcare provider or pharmacist for guidance.

What side effects can this medication cause?

Daurismo (glasdegib) can cause various side effects, ranging from mild to severe. Not everyone will experience these side effects, and their severity can vary from person to person. Common side effects of Daurismo include:

• Bone marrow suppression: Daurismo can lower the production of blood cells in the bone marrow, leading to side effects such as anemia (low red blood cell count), thrombocytopenia (low platelet count), and neutropenia (low white blood cell count). This may result in symptoms like fatigue, weakness, increased risk of bleeding or infection, and easy bruising.
• Gastrointestinal effects: Nausea, vomiting, diarrhea, constipation, and abdominal pain are common gastrointestinal side effects of Daurismo. These symptoms are typically mild to moderate and can often be managed with supportive measures such as dietary changes or medications.
• Fatigue: Many patients experience fatigue or weakness while taking Daurismo. Getting adequate rest and engaging in gentle exercise or activities may help alleviate these symptoms.
• Musculoskeletal symptoms: Some people may experience muscle pain, joint pain, or weakness while taking Daurismo. These symptoms are usually mild and temporary but should be reported to your healthcare provider if they persist or worsen.
• Electrolyte abnormalities: Daurismo may cause changes in electrolyte levels, such as hypokalemia (low potassium levels) or hypomagnesemia (low magnesium levels), which can lead to symptoms like muscle cramps, weakness, or irregular heartbeats.
• Liver toxicity: Rarely, Daurismo can cause liver problems, including elevated liver enzymes, hepatitis, or liver failure. Symptoms may include jaundice (yellowing of the skin and eyes), abdominal pain, or dark urine. If you experience any signs of liver problems, contact your healthcare provider immediately.
• Cardiac effects: Daurismo may prolong the QT interval, which can lead to abnormal heart rhythms. While this side effect is uncommon, it can be serious. Symptoms of cardiac toxicity may include dizziness, fainting, or irregular heartbeats.
• Other side effects: Additional side effects of Daurismo may include headache, rash, fever, cough, and respiratory infections.

It’s essential to report any side effects or concerns to your healthcare provider promptly. They can provide guidance on managing side effects and adjust your treatment plan if necessary.

What should I know about storage and disposal of this medication?

For the storage and disposal of Daurismo (glasdegib), here are some important points to keep in mind:

Storage:

• Store Daurismo tablets at room temperature between 20°C to 25°C (68°F to 77°F).
• Keep the medication in its original packaging or container to protect it from light and moisture.
• Avoid storing Daurismo in the bathroom or kitchen, where moisture and heat levels can fluctuate.
• Keep Daurismo out of reach of children and pets.

Disposal:

• Dispose of any unused or expired Daurismo tablets properly according to local regulations or guidelines.
• Do not flush Daurismo down the toilet or pour it down the drain unless instructed to do so by a healthcare professional or pharmacist.
• Consult your healthcare provider or pharmacist for information on how to safely dispose of Daurismo tablets. They may recommend using a drug take-back program or returning the medication to a pharmacy for disposal.

In case of emergency/overdose

• Contact emergency medical services (911 in the United States or your local emergency number) immediately if you or someone else may have overdosed on Daurismo.
• If possible, provide information about the medication taken, the amount ingested, and the time of ingestion.
• Do not attempt to induce vomiting unless instructed to do so by medical personnel.
• Seek medical attention promptly, as overdose of Daurismo may require supportive care and monitoring by healthcare professionals.

What other information should I know?

• Inform all healthcare providers involved in your care, including dentists and pharmacists, that you are taking Daurismo.
• Attend all scheduled appointments for monitoring and blood tests as recommended by your healthcare provider.
• Do not stop taking Daurismo or change your dosage without consulting your doctor, as this may affect the effectiveness of your treatment.
• It’s important to understand the potential side effects of Daurismo and report any new or worsening symptoms to your healthcare provider promptly.
• If you have any questions or concerns about Daurismo or your treatment plan, don’t hesitate to discuss them with your healthcare provider.