Dantrolene can seriously harm the liver. Dantrolene should only be used for the problems that your doctor has prescribed. Do not take more medication than your doctor has advised. If you have liver illness, avoid taking dantrolene. Call your doctor right away if you have any of the following symptoms: Yellowing of the skin or eyes, dark urine, black tarry stools, nausea, vomiting, weight loss, stomach pain in the upper right portion, or unusual bleeding or bruising.

Keep all of your appointments with your physician and the lab. Before and during your therapy, your doctor will request specific lab tests to monitor how you are responding to dantrolene.

Dantrolene is used to treat spasticity (muscle stiffness and tightness) or muscular spasms brought on by cerebral palsy, multiple sclerosis, spinal cord injuries, and strokes. Dantrolene belongs to a group of drugs known as skeletal muscle relaxants and is used to treat, prevent, or lessen the risk of malignant hyperthermia, a disease that involves a rapid rise in body temperature and muscle spasms. Dantrolene treats and prevents malignant hyperthermia by acting on the spinal cord’s nerves.

Dantrolene is available as a capsule to ingest. When used to treat spasticity, the dosage is often increased gradually every 7 days from once daily for 7 days to three to four times daily. It is often administered three to four times per day beginning one or two days before to surgery when used to avoid malignant hyperthermia. After a malignant hyperthermia crisis, it is often administered for 1 to 3 days in 4 split doses. Ask your doctor or chemist to explain any instructions on your prescription label that you are unsure about following. Follow the prescription for dantrolene exactly. Never take it in larger or less amounts or more frequently than recommended by your doctor.

For spasticity, your doctor will likely put you on a modest dose of dantrolene and gradually increase it, not more than once every seven days. Call your doctor if, 45 days after starting to use dantrolene, your symptoms do not improve or worsen.

Ask your doctor or chemist for more details if you’re interested in using this medication for any other conditions.

Before taking dantrolene,

• If you have an allergy to dantrolene, any other medications, or any of the substances in dantrolene capsules, let your doctor and chemist know right once. Get a list of the ingredients from your chemist.
• Inform your doctor and chemist about any additional prescription and over-the-counter drugs, vitamins, dietary supplements, and herbal products you are now taking or intend to use. Incorporate any of the following: Antidepressants, anxiety drugs, and calcium channel blockers including felodipine (Plendil), isradipine (DynaCirc), nicardipine, and diltiazem (Cardizem, Dilacor, and others) (Cardene), estrogen-containing birth control pills, patches, rings, and injections; nifedipine (Adalat, Procardia), nimodipine (Nimotop), nisoldipine (Sular), and verapamil (Calan, Verelan); or oestrogen replacement therapy, drugs for seizures, drugs for mental illness, sedatives, sleep aids, or tranquillizers. Your physician might need to adjust the dosage of your drugs or keep a close eye on you for side effects.
• Inform your doctor if you suffer from, or have ever suffered from, muscle spasms as a result of a rheumatic disorder, heart illness, or lung disease.
• Inform your doctor if you are expecting, intend to get pregnant, or are nursing a baby. Dial your doctor at once if you become pregnant while using dantrolene.
• You should let your doctor or dentist know if you are taking dantrolene if you are undergoing surgery, including dental surgery.
• You ought to be aware that dantrolene might make you sleepy. Prior to understanding how this drug affects you, avoid using machinery or driving a car.
• Inquire with your doctor if drinking alcohol is okay for you to do so while taking dantrolene. The negative effects of dantrolene might be exacerbated by alcohol.
• You should make a plan to limit your time spent in the sun and to wear sunscreen, sunglasses, and protective clothes. Your skin could become photosensitive if you take dandrolene.

If you miss a dosage, take it as soon as you recall. If the next dose is soon due, skip the missed one and carry on with your regular dosing plan. To make up for a missing dose, do not take a second one.

Dantrolene could have negative effects. If any of these symptoms are severe or do not go away, let your doctor know right once:

• Muscular tremor
• Dizziness
• Diarrhea
• Fatigue

Call your doctor right away if you suffer any of the following symptoms in addition to those listed in the IMPORTANT CAUTION section:

• Seizures
• Breathing issues or shallow, sluggish breathing

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

Keep this medication tightly closed in the original container and out of the reach of children. Keep it away from excessive heat and moisture at room temperature (not in the bathroom).

Although many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for young children to open, it is crucial to keep all medications out of sight and out of reach of children. Always lock safety caps and promptly stash medication up and away from young children where it is out of their sight and reach to prevent poisoning. http://www.upandaway.org

Unused prescriptions must be disposed of carefully to prevent pets, kids, and other people from ingesting them. You should not, however, dispose of this medication in the toilet. Instead, utilising a medicine take-back programme is the easiest approach to get rid of your medication. To find out about take-back programmes in your area, speak with your chemist or the garbage/recycling agency in your city. If you do not have access to a take-back programme, see the FDA’s Safe Disposal of Medications website at http://goo.gl/c4Rm4p for additional information.

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Moreover, information can be found online at https://www.poisonhelp.org/help. Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

Symptoms of overdose may include:

• Vomiting
• Diarrhea
• Muscular tremor
• Extreme fatigue
• Coma

No one else should take your medication. Any queries you may have regarding prescription refills should be directed to your chemist.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.