Why is this medication prescribed?

Pancrelipase is an enzyme replacement therapy that helps to digest fats, proteins, and carbohydrates in the food we eat. People with pancreatic insufficiency lack the necessary digestive enzymes produced by the pancreas, leading to difficulty in digesting food and absorbing nutrients.

How should this medicine be used?

Creon, which is a brand name for pancrelipase, is used to aid in the digestion of fats, proteins, and carbohydrates in people who have pancreatic enzyme deficiencies, such as those with cystic fibrosis or chronic pancreatitis. Here’s how Creon (pancrelipase) should typically be used:

• Dosage: The dosage of Creon depends on the individual’s needs, typically determined by a healthcare provider based on the severity of pancreatic insufficiency and the patient’s diet.
• Administration: Creon should be taken with every meal or snack to help digest food properly. It is usually taken orally, with sufficient liquid, and ideally at the beginning of the meal.
• Dosage Adjustment: The dosage may need adjustment based on the patient’s response and changes in diet or pancreatic function over time. This should always be done under medical supervision.
• Monitoring: Regular monitoring by a healthcare provider is important to ensure that the dosage is appropriate and to assess any changes in pancreatic function or dietary needs.
• Storage: Store Creon at room temperature away from moisture and heat. Avoid storing it in the bathroom or other humid places.
• Special Instructions: Always follow the specific instructions given by your healthcare provider or pharmacist regarding the use of Creon. They can provide guidance on how to take it effectively and maximize its benefits.

It’s crucial to take Creon as prescribed and to follow dietary recommendations provided by your healthcare provider to manage pancreatic insufficiency effectively. If there are any questions or concerns about using Creon, consulting with a healthcare professional is advisable.

Other uses for this medicine

• Pancreatic Cancer: In some cases of pancreatic cancer where the tumor obstructs the pancreatic ducts and affects enzyme production, Creon may be prescribed to aid digestion.
• Post-Surgical Pancreatic Insufficiency: After surgical procedures involving the pancreas, such as pancreatectomy (partial or complete removal of the pancreas), Creon may be used to manage pancreatic enzyme deficiencies.

What special precautions should I follow?

Special Precautions for Creon:

• Allergies: If you have known allergies to pork (since Creon is derived from pigs) or any other ingredients in Creon, inform your healthcare provider.
• Dosage Adjustment in Children: Pediatric dosing of Creon should be carefully monitored and adjusted based on weight and age to ensure effectiveness and safety.
• Pregnancy and Breastfeeding: There is limited information on the use of Creon during pregnancy and breastfeeding. Consult with your healthcare provider to weigh the benefits and risks before using Creon in these situations.
• Other Medical Conditions: Inform your healthcare provider about any other medical conditions you have, especially gastrointestinal conditions, before starting Creon.
• Drug Interactions: Creon may interact with certain medications, such as antacids and proton pump inhibitors, affecting its effectiveness. Discuss all medications and supplements you are taking with your healthcare provider.
• Monitoringv Regular monitoring of pancreatic function, nutritional status, and response to Creon is important. Your healthcare provider may adjust the dosage based on these factors.
• Storage: Store Creon according to the manufacturer’s instructions, usually at room temperature away from moisture and heat.

Always follow the specific instructions provided by your healthcare provider or pharmacist regarding the use of Creon. They can provide guidance tailored to your individual needs and medical history. If you experience any unusual symptoms or side effects while taking Creon, contact your healthcare provider promptly.

What special dietary instructions should I follow?

• High-fat Meals: Creon is taken with meals to aid in the digestion of fats, proteins, and carbohydrates. Follow a diet that includes adequate fat intake to ensure Creon is effective. Your healthcare provider or dietitian can provide specific guidance on your dietary needs.
• Balanced Diet: Maintain a balanced diet that includes a variety of foods to support overall nutrition. Avoid skipping meals, as this can affect the effectiveness of Creon.
• Fluid Intake: Drink sufficient fluids with each dose of Creon to help ensure proper digestion and absorption of nutrients.

What should I do if I forget a dose?

• If it’s close to your next scheduled dose: Skip the missed dose and take your next dose at the regular time.
• If it’s not close to your next scheduled dose: Take the missed dose as soon as you remember, then continue with your regular dosing schedule.

What side effects can this medication cause?

Creon (pancrelipase) may cause some side effects, although not everyone using it will experience them. Common side effects include:

• Gastrointestinal Upset: This can include abdominal pain, bloating, gas, diarrhea, or constipation. These symptoms may occur if the dosage of Creon is not adjusted correctly or if there are changes in diet or pancreatic function.
• Nausea and Vomiting: Some people may experience nausea or vomiting, particularly if Creon is not taken with enough fluid or if the dosage is too high.
• Allergic Reactions: Rarely, allergic reactions to Creon may occur, which can manifest as rash, itching, swelling of the face or throat, severe dizziness, or trouble breathing. Seek immediate medical attention if you experience any signs of an allergic reaction.
• High Uric Acid Levels (Hyperuricemia): In some cases, Creon may increase uric acid levels in the blood, which could lead to gout or kidney stones.
• Fibrosing Colonopathy: This is a rare condition associated with high doses of pancreatic enzyme supplements like Creon. It involves thickening of the wall of the colon and may lead to symptoms similar to those of Crohn’s disease or intestinal obstruction.
• Mouth Irritation: Some users may experience irritation or sores in the mouth.
• Elevated Blood Glucose Levels: Creon may affect blood glucose levels, especially in individuals with diabetes. Monitoring blood sugar levels may be necessary.
• Respiratory Symptoms: There have been reports of respiratory symptoms such as coughing or shortness of breath, although these are less common.

It’s important to note that these are not all the possible side effects of Creon. If you experience any unusual symptoms while taking Creon, particularly severe abdominal pain, persistent diarrhea, or signs of an allergic reaction, contact your healthcare provider immediately.

To minimize the risk of side effects, follow your healthcare provider’s instructions carefully regarding dosage, dietary adjustments, and any other recommendations specific to your condition. Regular monitoring and communication with your healthcare provider can help manage any potential side effects effectively.

What should I know about storage and disposal of this medication?

Storage and Disposal:

• Storage: Store Creon (pancrelipase) capsules at room temperature, away from moisture and heat. Avoid storing them in the bathroom or kitchen where humidity and temperature fluctuations can affect the medication.
• Capsules: Keep the capsules in their original container with the lid tightly closed.
• Keep Out of Reach: Store Creon out of reach of children and pets to prevent accidental ingestion.

In case of emergency/overdose

• Signs of Overdose: Symptoms of Creon overdose may include abdominal pain, bloating, diarrhea, or constipation. If you suspect an overdose or experience severe symptoms, seek immediate medical attention or contact a poison control center.
• Treatment of Overdose: Treatment for Creon overdose typically involves supportive care to manage symptoms. It may include adjustments to fluid intake, electrolyte balance, and possibly reducing or temporarily stopping Creon until symptoms resolve.

What other information should I know?

• Administration: Creon should be taken with meals and snacks according to your doctor’s instructions.
• Monitoring: Regularly monitor your response to Creon and report any persistent or worsening symptoms to your healthcare provider.
• Side Effects: Be aware of common side effects such as abdominal pain, diarrhea, or changes in bowel habits. Contact your doctor if these become severe or persistent.
• Interactions: Inform your doctor of all other medications you are taking, as some drugs may interact with Creon.
• Pregnancy and Breastfeeding: Discuss the risks and benefits of taking Creon if you are pregnant or breastfeeding.

Always follow your healthcare provider’s instructions regarding the use, storage, and disposal of Creon. If you have any questions or concerns, do not hesitate to consult your pharmacist or doctor for clarification.