Why is this medication prescribed?

Cosentyx (secukinumab) is prescribed primarily to treat certain autoimmune conditions, particularly moderate to severe plaque psoriasis, psoriatic arthritis, ankylosing spondylitis, and moderate to severe plaque psoriasis in children ages 6 years and older. It is a biologic medication that works by targeting and inhibiting a specific protein (IL-17A) involved in the inflammatory response of these conditions.

Here’s a brief overview of the conditions Cosentyx is prescribed for:

• Plaque Psoriasis: This is a chronic autoimmune skin condition characterized by red, raised, and scaly patches on the skin. Cosentyx helps reduce the inflammation associated with plaque psoriasis, leading to clearer skin.
• Psoriatic Arthritis: This is a type of arthritis that affects some people with psoriasis. It causes joint pain, stiffness, and swelling, along with inflammation in other parts of the body. Cosentyx helps reduce symptoms and progression of psoriatic arthritis.
• Ankylosing Spondylitis: This is a type of arthritis that primarily affects the spine, causing inflammation, pain, and stiffness in the back and neck. Cosentyx helps reduce inflammation in the spine and other joints affected by ankylosing spondylitis.

Cosentyx is usually prescribed when other treatments, such as nonsteroidal anti-inflammatory drugs (NSAIDs) or disease-modifying antirheumatic drugs (DMARDs), have not provided adequate relief or are not suitable. It is typically administered as an injection under the skin (subcutaneous injection) and is known for its efficacy in managing symptoms and improving quality of life for patients with these conditions.

How should this medicine be used?

Cosentyx (secukinumab) is a medication that is typically administered as a subcutaneous injection. Here are the general guidelines on how it should be used:

• Dosage: The dosage of Cosentyx can vary depending on the condition being treated and the patient’s response to the medication. It is important to follow the specific dosage instructions provided by your healthcare provider.
• Administration: Cosentyx is injected under the skin (subcutaneously). It can be self-administered or administered by a healthcare professional. Your doctor or nurse will instruct you on the proper technique for administering the injection.
• Injection Sites: Common injection sites for Cosentyx include the thighs, abdomen (except for the navel area), or upper arms. It’s important to rotate injection sites to minimize the risk of injection site reactions.
• Frequency: The dosing schedule for Cosentyx can vary. Initially, it may be given as a loading dose followed by maintenance doses. For example, for plaque psoriasis, the usual maintenance dosing schedule is every 4 weeks after the initial loading doses.
• Monitoring: Your healthcare provider will monitor your response to Cosentyx and may adjust the dosage or frequency of injections based on your condition and how well you respond to treatment.
• Storage: Cosentyx should be stored in the refrigerator between 36°F to 46°F (2°C to 8°C). It should be protected from light and should not be frozen. Before use, allow the prefilled syringe or pen to sit at room temperature for about 30 minutes to reach a comfortable temperature.
• Consultation: Always consult your healthcare provider if you have any questions or concerns about how to use Cosentyx. They can provide personalized guidance based on your specific medical condition and needs.

It’s crucial to follow your doctor’s instructions carefully regarding the use of Cosentyx to ensure its effectiveness and minimize any potential risks or side effects.

Other uses for this medicine

Cosentyx (secukinumab) is primarily used for treating autoimmune conditions such as plaque psoriasis, psoriatic arthritis, and ankylosing spondylitis. It specifically targets and inhibits interleukin-17A (IL-17A), a cytokine involved in the inflammatory processes of these conditions. While it’s mainly prescribed for these conditions, there are ongoing studies exploring its potential use in other autoimmune and inflammatory diseases.

What special precautions should I follow?

Special Precautions for Cosentyx:

• Infections: Cosentyx can suppress the immune system, increasing the risk of infections. Before starting treatment, inform your healthcare provider about any current infections or a history of recurrent infections. It’s important to avoid administration of live vaccines during treatment with Cosentyx.
• Tuberculosis (TB): Patients should be screened for latent TB infection before starting Cosentyx. Treatment for latent TB should be initiated prior to starting Cosentyx if indicated.
• Allergic Reactions: If you have had a severe allergic reaction to Cosentyx or any of its ingredients, inform your healthcare provider. Allergic reactions to Cosentyx are rare but can occur.
• Immunizations: Ensure that all recommended vaccinations are up to date before starting Cosentyx. Live vaccines should not be administered during treatment with Cosentyx.
• Pregnancy and Breastfeeding: Cosentyx should be used during pregnancy only if clearly needed and after discussion with your healthcare provider. It is not known whether Cosentyx passes into breast milk, so a decision should be made whether to discontinue breastfeeding or discontinue Cosentyx, taking into account the importance of the drug to the mother.
• Monitoring: Regular monitoring by your healthcare provider is important to assess your response to Cosentyx and monitor for any potential side effects or complications.
• Side Effects: Common side effects of Cosentyx include upper respiratory tract infections, diarrhea, and reactions at the injection site. Less common but more serious side effects may include allergic reactions, infections, and changes in liver function tests.

Always follow your healthcare provider’s instructions and guidance regarding the use of Cosentyx. They can provide personalized advice based on your medical history and current health status. If you experience any unusual symptoms or side effects while taking Cosentyx, contact your healthcare provider promptly.

What special dietary instructions should I follow?

There are no specific dietary restrictions or instructions associated with Cosentyx. However, maintaining a healthy and balanced diet is generally recommended for overall health and well-being, especially if you have a chronic condition like psoriasis or arthritis.

What should I do if I forget a dose?

• As Soon As You Remember: If you realize you missed your dose shortly after the scheduled time, you can administer the injection as soon as you remember.
• Skip If Close to Next Dose: If it is close to the time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule.
• Consult Your Healthcare Provider: It’s always a good idea to inform your healthcare provider if you miss a dose. They can provide guidance on whether any adjustments to your dosing schedule are necessary.
• Do Not Double Dose: Do not administer a double dose to make up for a missed one. This can increase the risk of side effects without providing any additional benefit.

What side effects can this medication cause?

Cosentyx (secukinumab) is generally well-tolerated, but like any medication, it can cause side effects. Common side effects may include:

• Upper Respiratory Tract Infections: Such as the common cold.
• Diarrhea: Gastrointestinal symptoms like diarrhea can occur.
• Injection Site Reactions: Redness, itching, or pain at the injection site are possible.
• Headache: Some individuals may experience headaches.
• Nausea: Feeling sick to your stomach.
• Fatigue: Feeling tired or fatigued.
• Hypertension: Elevated blood pressure has been reported in some cases.
• Allergic Reactions: Rarely, severe allergic reactions can occur. Signs may include rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, or trouble breathing.
• Infections: There is an increased risk of infections, including upper respiratory infections and fungal infections.
• Liver Enzyme Abnormalities: Changes in liver function tests have been observed in some patients.
• Neutropenia: A decrease in a type of white blood cell called neutrophils, which can increase the risk of infections.
• Inflammatory Bowel Disease: Cases of new or worsening inflammatory bowel disease (such as Crohn’s disease and ulcerative colitis) have been reported.

It’s important to note that not everyone will experience these side effects, and some people may not experience any at all. If you experience any unusual symptoms or side effects while taking Cosentyx, it’s important to notify your healthcare provider promptly. They can evaluate your symptoms and determine the appropriate course of action, which may include adjusting your treatment regimen if necessary.

What should I know about storage and disposal of this medication?

Storage and Disposal of Cosentyx:

• Storage:
  • Cosentyx is typically supplied as a prefilled syringe or a prefilled pen.
  • Store Cosentyx in the refrigerator between 36°F to 46°F (2°C to 8°C).
  • Protect from light.
  • Do not freeze Cosentyx.
  • If necessary, the prefilled syringe or pen can be kept at room temperature (up to 77°F or 25°C) for a single period of up to 30 days. Do not return it to the refrigerator after it has been kept at room temperature.
  • Keep Cosentyx and all medications out of the reach of children and pets.
• Disposal:
  • Dispose of used needles and syringes or pens in a puncture-resistant container (such as a sharps container).
  • Do not throw away needles, syringes, or pens in the household trash or recycling bin.
  • Follow local regulations or guidelines for proper disposal of medical waste.

In case of emergency/overdose

In case of an emergency or suspected overdose (such as accidental administration of multiple doses):

• Contact your healthcare provider, emergency medical services, or go to the nearest emergency room immediately.
• Do not attempt to treat an overdose on your own.

What other information should I know?

• Monitoring: Your healthcare provider will monitor your response to Cosentyx and may perform regular blood tests to check for side effects, such as changes in liver function or white blood cell counts.
• Interactions: Inform your healthcare provider about all other medications you are taking, including over-the-counter drugs, vitamins, and herbal supplements. Some medications may interact with Cosentyx.
• Live Vaccines: Avoid live vaccines while taking Cosentyx, as it may interfere with the vaccine’s effectiveness.
• Travel: If you need to travel with Cosentyx, consider how you will store it properly (refrigerated or at room temperature) and plan accordingly.
• Support: Consider joining support groups or connecting with patient advocacy organizations for additional information and support related to your condition and treatment with Cosentyx.

Always follow your healthcare provider’s instructions and guidance regarding the use, storage, and disposal of Cosentyx. They can provide personalized advice based on your specific medical condition and needs. If you have any questions or concerns about Cosentyx or its administration, do not hesitate to discuss them with your healthcare provider.