Warning

Copanlisib is a medication used to treat certain types of cancer, including some types of lymphoma. While effective, it does come with risks. Common side effects include:

• Infections: Increased risk of infections due to its effect on the immune system.
• Elevated Blood Sugar: Can cause or worsen diabetes, leading to high blood sugar levels.
• Liver Issues: Potential for liver inflammation or damage.
• Gastrointestinal Issues: Nausea, vomiting, diarrhea, and other digestive problems.
• Fatigue and Weakness: General tiredness and decreased energy levels.
• Heart Issues: Potential for heart-related side effects, though less common.

It’s important to discuss these risks with your healthcare provider, who can help manage and monitor any side effects.

Why is this medication prescribed?

Copanlisib is prescribed primarily for the treatment of certain types of non-Hodgkin lymphoma, particularly follicular lymphoma, that have not responded to other treatments or have relapsed. It works by inhibiting specific enzymes (PI3K kinases) that are involved in the growth and survival of cancer cells.

How should this medicine be used?

Here are general guidelines on how it should be used:

• Administration: Copanlisib is given as an injection into a vein (intravenous, IV) by a healthcare professional. It’s typically administered in a clinical setting.
• Dosage and Schedule: The dosage and schedule are determined by the healthcare provider based on the patient’s condition and response to the drug. It’s generally given in cycles, often with a specified number of weeks between doses.
• Monitoring: Regular monitoring of blood tests, liver function, blood sugar levels, and overall health is necessary to manage potential side effects and adjust the treatment as needed.

Always follow the healthcare provider’s instructions regarding the use of Copanlisib and attend all scheduled appointments for monitoring and administration.

Other uses for this medicine

While Copanlisib is primarily used for treating certain types of non-Hodgkin lymphoma, its use is continually being explored in clinical trials for other types of cancer. Research may investigate its effectiveness in treating other hematological malignancies or solid tumors, but its approved indications are specific to non-Hodgkin lymphoma at this time.

What special precautions should I follow?

Special Precautions:

• Pre-existing Conditions: Inform your healthcare provider if you have a history of diabetes, liver disease, heart conditions, or infections. Copanlisib can exacerbate these conditions or interact with existing treatments.
• Infection Risk: Since Copanlisib can weaken the immune system, it’s important to avoid contact with people who have infections or to take precautions to avoid infections. Report any signs of infection (fever, chills, etc.) immediately.
• Blood Sugar Levels: Regularly monitor blood glucose levels, especially if you have a history of diabetes or are at risk for high blood sugar. Manage any changes in blood sugar levels with your healthcare provider’s guidance.
• Liver Function: Periodic liver function tests are necessary to monitor for any potential liver issues. Report any symptoms of liver problems (yellowing of the skin or eyes, dark urine, etc.) to your healthcare provider.
• Pregnancy and Breastfeeding: Inform your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding. Copanlisib may harm an unborn baby or pass into breast milk.
• Drug Interactions: Make sure your healthcare provider is aware of all other medications and supplements you are taking, as Copanlisib can interact with certain drugs, affecting its efficacy or increasing side effects.

Always follow your healthcare provider’s specific instructions and report any side effects or concerns you experience during treatment.

What special dietary instructions should I follow?

There are no specific dietary restrictions associated with Copanlisib. However, maintaining a balanced diet can help manage side effects and support overall health. If you experience gastrointestinal issues like nausea or diarrhea, consider eating small, frequent meals and staying hydrated. Consult your healthcare provider for personalized dietary advice.

What should I do if I forget a dose?

If you miss a dose of Copanlisib, contact your healthcare provider or clinic for guidance. They will advise you on whether to take the missed dose or reschedule your next dose. Do not double up on doses to make up for a missed one. Following your provider’s instructions is crucial to ensure effective and safe treatment

What side effects can this medication cause?

Copanlisib can cause various side effects, some of which may be serious. Common and less serious side effects include:

Common Side Effects:

• Fatigue: Feeling unusually tired or weak.
• Gastrointestinal Issues: Nausea, vomiting, diarrhea, and loss of appetite.
• Elevated Blood Sugar: Increased risk of hyperglycemia (high blood sugar), which may require monitoring and management.
• Infusion Reactions: Reactions during or shortly after the infusion, such as chills, fever, or rash.
• Infections: Increased susceptibility to infections due to its impact on the immune system.

Serious Side Effects:

• Liver Issues: Potential for liver inflammation or damage, which may manifest as jaundice (yellowing of the skin or eyes), dark urine, or severe abdominal pain.
• Increased Risk of Bleeding: Can affect blood clotting and increase bleeding or bruising.
• Heart Problems: Although less common, can include heart failure or other cardiac issues.
• Severe Infections: Potential for serious infections due to weakened immune response, such as pneumonia or sepsis.
• Severe Hyperglycemia: Significant elevation in blood sugar levels, which may require insulin or other medications to control.

Rare but Serious Side Effects:

• Pulmonary Issues: Rare cases of interstitial lung disease or pneumonitis.
• Severe Allergic Reactions: Such as anaphylaxis, which may include symptoms like difficulty breathing, swelling of the face or throat, and severe rash.

Always report any new or worsening symptoms to your healthcare provider promptly. They can help manage side effects and adjust your treatment as needed.

What should I know about storage and disposal of this medication?

Storage and Disposal:

• Storage:
  • In the Clinic: Copanlisib is usually administered in a healthcare setting, where it is stored according to the manufacturer’s guidelines.
  • For Home Use: If you receive Copanlisib for at-home administration (which is less common), follow specific storage instructions provided by your healthcare provider or pharmacist. Typically, it should be kept in a cool, dry place away from direct light and moisture.
  • Temperature: Ensure it is stored at the recommended temperature. Some medications need refrigeration, while others should be kept at room temperature.
• Disposal:
  • Unused Medication: Follow local guidelines or pharmacy instructions for the disposal of unused or expired medication. Do not dispose of it in household trash or flush it down the toilet unless directed to do so.
  • Return to Pharmacy: Many pharmacies have take-back programs for medications. Check if your pharmacy offers this service.

In case of emergency/overdose

• Emergency:
  • Contact Healthcare Provider: If you experience severe side effects or symptoms of a serious allergic reaction (such as difficulty breathing, swelling of the face or throat, or a severe rash), seek immediate medical attention.
  • Call Emergency Services: For life-threatening situations, call emergency services right away.
• Overdose:
  • Symptoms: An overdose might lead to severe side effects, including severe nausea, vomiting, high blood sugar, liver issues, or significant infusion reactions.
  • Immediate Action: Contact your healthcare provider or local poison control center immediately. They will provide guidance on the next steps and may instruct you to go to the nearest emergency room.

What other information should I know?

• Medical History: Keep your healthcare provider informed about any changes in your medical history or health status.
• Regular Monitoring: Adhere to scheduled appointments for monitoring and lab tests to assess the drug’s effect and manage side effects.
• Medication List: Maintain a list of all medications, including over-the-counter drugs and supplements, and share it with your healthcare provider to avoid interactions.
• Pregnancy and Breastfeeding: Inform your provider if you are pregnant, planning to become pregnant, or breastfeeding. Copanlisib can have risks for the fetus or infant.

Always follow the specific instructions given by your healthcare provider regarding Copanlisib.