WARNING

Estrogen vaginal therapy, typically prescribed in the form of creams, tablets, or rings, carries certain risks that users should be aware of:

• Increased risk of cancer: Long-term use of estrogen vaginal therapy may slightly increase the risk of certain cancers, such as breast cancer, ovarian cancer, and endometrial cancer. However, the risk is generally considered to be low, especially with short-term use.
• Blood clots: Estrogen therapy, including vaginal forms, can increase the risk of blood clots, which can lead to serious conditions like deep vein thrombosis or pulmonary embolism. This risk is higher in women with certain medical conditions or risk factors.
• Endometrial hyperplasia: Estrogen therapy alone, without the use of progestin in women who have not undergone hysterectomy, can lead to thickening of the lining of the uterus (endometrial hyperplasia), which may increase the risk of endometrial cancer.
• Breast tenderness: Some women may experience breast tenderness or enlargement while using estrogen vaginal therapy.
• Nausea and bloating: Estrogen therapy can cause nausea, bloating, and other gastrointestinal symptoms in some users.
• Vaginal irritation: Some women may experience vaginal irritation, itching, or discharge as a side effect of estrogen vaginal therapy.
• Worsening of certain conditions: Estrogen therapy may worsen certain medical conditions such as asthma, diabetes, epilepsy, migraine headaches, and liver disease.

It’s important for individuals considering estrogen vaginal therapy to discuss the potential risks and benefits with their healthcare provider, especially if they have a history of certain medical conditions or risk factors. Regular monitoring and follow-up appointments can help mitigate risks and ensure the therapy is safe and effective.

Why is this medication prescribed?

Estrogen vaginal therapy is prescribed for several reasons, including:

• Vaginal dryness: It is commonly used to relieve symptoms of vaginal dryness, itching, burning, and discomfort, which can occur due to hormonal changes during menopause or as a result of certain medical treatments such as chemotherapy or hormonal therapy for breast cancer.
• Dyspareunia: Estrogen vaginal therapy may be prescribed to alleviate pain during sexual intercourse (dyspareunia) caused by vaginal dryness or thinning of the vaginal tissues.
• Vaginal atrophy: It is also used to treat vaginal atrophy, a condition characterized by thinning, inflammation, and loss of elasticity of the vaginal tissues, often occurring due to declining estrogen levels during menopause.
• Recurring urinary tract infections (UTIs): Estrogen vaginal therapy may be recommended for postmenopausal women experiencing recurrent UTIs, as it can help restore the normal vaginal pH and flora, reducing the risk of infection.

How should this medicine be used?

Estrogen vaginal therapy comes in various forms, including creams, tablets, and vaginal rings. The specific instructions for use may vary depending on the formulation prescribed by the healthcare provider. However, general guidelines for using estrogen vaginal therapy include:

• Follow healthcare provider’s instructions: Always use estrogen vaginal therapy exactly as prescribed by your healthcare provider. Do not use more or less of it, or use it more often than instructed.
• Administration: Depending on the formulation, estrogen vaginal therapy is typically applied directly into the vagina using an applicator (for creams or tablets) or inserted into the vagina (for rings). Follow the specific instructions provided with the product.
• Timing: Estrogen vaginal therapy is often prescribed for daily or weekly use. Use it consistently at the same time each day or week, as directed by your healthcare provider.
• Duration: Use estrogen vaginal therapy for the prescribed duration. Some women may require short-term therapy to alleviate acute symptoms, while others may need long-term maintenance therapy.
• Monitor for side effects: Be aware of any potential side effects associated with estrogen vaginal therapy, and promptly report any concerns or adverse reactions to your healthcare provider.
• Regular follow-up: Attend follow-up appointments with your healthcare provider as recommended to monitor the effectiveness of the therapy and discuss any changes in symptoms or concerns.

Always consult with a healthcare professional for personalized advice and guidance regarding the use of estrogen vaginal medications.

Other uses for this medicine

Other Uses for Estrogen Vaginal:

• Treatment of vaginal atrophy (thinning, drying, and inflammation of the vaginal walls) associated with menopause.
• Management of symptoms related to vaginal dryness, itching, and burning caused by hormonal imbalances.
• Some healthcare providers may prescribe estrogen vaginal products for certain gynecological conditions, but it’s essential to use them only as directed by your doctor.

What special precautions should I follow?

When using estrogen vaginal therapy, it’s important to follow certain precautions to ensure safe and effective treatment:

• Inform your healthcare provider: Before starting estrogen vaginal therapy, inform your healthcare provider about any medical conditions you have, especially a history of breast cancer, uterine cancer, blood clots, heart disease, liver disease, or abnormal vaginal bleeding.
• Regular check-ups: Attend regular check-ups with your healthcare provider while using estrogen vaginal therapy to monitor its effectiveness and assess for any adverse effects.
• Breast self-exams: Perform regular breast self-examinations and report any new or worsening breast lumps, nipple discharge, or breast changes to your healthcare provider.
• Limit use in certain conditions: Estrogen vaginal therapy may not be suitable for everyone. It should be used with caution or avoided in women with a history of certain conditions such as endometrial hyperplasia, endometrial cancer, or undiagnosed vaginal bleeding.
• Avoid certain medications: Some medications, such as aromatase inhibitors used in breast cancer treatment, may interfere with the effectiveness of estrogen vaginal therapy. Inform your healthcare provider about all medications you are taking, including prescription, over-the-counter, and herbal supplements.
• Monitor for side effects: Be vigilant for any potential side effects of estrogen vaginal therapy, including breast tenderness, vaginal irritation, nausea, bloating, or changes in vaginal discharge. Promptly report any concerns to your healthcare provider.
• Use lowest effective dose: To minimize the risk of side effects, use the lowest effective dose of estrogen vaginal therapy for the shortest duration necessary to achieve symptom relief.

What special dietary instructions should I follow?

Special dietary instructions for estrogen vaginal therapy are generally not necessary. However, maintaining a balanced diet rich in fruits, vegetables, whole grains, and lean proteins is always recommended for overall health and well-being.

What should I do if I forget a dose?

If you forget a dose of estrogen vaginal therapy, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up. If you are unsure about what to do, or if you miss multiple doses, consult your healthcare provider or pharmacist for guidance. It’s essential to maintain consistent use of estrogen vaginal therapy for optimal effectiveness.

What side effects can this medication cause?

Estrogen vaginal therapy can potentially cause several side effects, although not everyone will experience them. Common side effects may include:

• Vaginal irritation: Some women may experience vaginal irritation, itching, or burning sensations after using estrogen vaginal therapy.
• Discharge: Estrogen vaginal therapy may cause changes in vaginal discharge, such as increased discharge or changes in consistency or odor.
• Breast tenderness: Some individuals may experience breast tenderness or enlargement while using estrogen vaginal therapy.
• Nausea and bloating: Estrogen therapy can sometimes lead to gastrointestinal symptoms such as nausea, bloating, or abdominal discomfort.
• Headaches: Headaches are another potential side effect of estrogen vaginal therapy, although they are usually mild and temporary.
• Spotting or breakthrough bleeding: Some women may experience spotting or breakthrough bleeding, especially during the first few months of treatment.
• Fluid retention: Estrogen therapy can occasionally cause fluid retention, leading to swelling or bloating in certain parts of the body, such as the hands, feet, or ankles.
• Mood changes: Estrogen therapy may affect mood in some individuals, leading to changes in mood or emotional sensitivity.
• Increased risk of certain conditions: Long-term use of estrogen vaginal therapy may slightly increase the risk of certain conditions, such as breast cancer, ovarian cancer, endometrial cancer, and blood clots. However, the absolute risk is generally low, especially with short-term use.

It’s important to note that the likelihood and severity of these side effects can vary from person to person. If you experience any concerning or persistent side effects while using estrogen vaginal therapy, it’s essential to consult your healthcare provider for guidance and possible adjustments to your treatment regimen.

What should I know about storage and disposal of this medication?

Storage and disposal of estrogen vaginal:

• Storage: Follow the storage instructions provided with your specific estrogen vaginal product. In general, estrogen vaginal creams, tablets, or rings should be stored at room temperature away from moisture, heat, and light. Keep them out of reach of children and pets.
• Disposal: Dispose of unused or expired estrogen vaginal products according to local regulations or guidelines. Do not flush them down the toilet unless instructed to do so. Instead, consult your pharmacist or healthcare provider for proper disposal methods, which may include returning them to a pharmacy or using a drug take-back program.

In case of emergency/overdose

In case of emergency or accidental ingestion of estrogen vaginal products, contact your local emergency services or poison control center immediately. Overdose of estrogen vaginal therapy may cause symptoms such as nausea, vomiting, breast tenderness, vaginal bleeding, or other adverse effects. Seek medical attention promptly if an overdose is suspected.

What other information should I know?

• Keep all appointments with your healthcare provider for regular check-ups and monitoring while using estrogen vaginal therapy.
• Inform your healthcare provider about any changes in your medical history, including new or worsening symptoms, before starting or during treatment with estrogen vaginal therapy.
• Follow your healthcare provider’s instructions carefully regarding the use and dosing schedule of estrogen vaginal products.
• Inform any other healthcare providers involved in your care, such as specialists or dentists, about your use of estrogen vaginal therapy.
• Report any unusual or concerning symptoms, side effects, or changes in your condition to your healthcare provider promptly.
• Avoid using tampons, douches, or other vaginal products while using estrogen vaginal therapy unless advised otherwise by your healthcare provider.
• Estrogen vaginal therapy may interact with certain medications or medical conditions. Inform your healthcare provider about all medications you are taking, including prescription, over-the-counter, and herbal supplements, before starting treatment.
• If you are pregnant, planning to become pregnant, or breastfeeding, discuss the risks and benefits of estrogen vaginal therapy with your healthcare provider before use.

By following these guidelines and staying informed about your treatment, you can use estrogen vaginal therapy safely and effectively under the guidance of your healthcare provider.