Sulindac is an example of an NSAID (non-aspirin) that some people who take may have a higher risk of developing a heart attack or stroke than those who do not take these drugs. These occurrences could be fatal and could occur suddenly. For those who take NSAIDs for an extended period of time, this risk may be larger. If you have recently experienced a heart attack, avoid taking an NSAID like sulindac unless your doctor specifically instructs you to. Inform your doctor if you smoke, have high cholesterol, high blood pressure, or diabetes, or if you or anyone in your family has ever suffered from heart disease, a heart attack, or a stroke. If you suffer any of the following symptoms, seek emergency medical attention right away: chest pain, shortness of breath, weakness on one side or area of the body, or slurred speech.

Sulindac should not be taken immediately prior to or immediately following a coronary artery bypass graft (CABG; a form of cardiac surgery).

Sulindac and other NSAIDs have been linked to stomach and intestine ulcers, bleeding, and holes. These issues could arise at any point during therapy, without any prior symptoms, and could be fatal. Those who take NSAIDs frequently, are older, have poorer health, or consume substantial amounts of alcohol while taking sulindac may be at higher risk. Inform your physician if you use any of the following drugs: Warfarin (Coumadin, Jantoven) and other anticoagulants (also known as “blood thinners”), aspirin, other NSAIDs like diflunisal, ibuprofen (Advil, Motrin), or naproxen (Aleve, Naprosyn), or oral steroids like dexamethasone, methylprednisolone (Medrol), and prednisone (Rayos), are examples of such medications. Selective serotonin reuptake inhibitors (SSRIs) include citalopram (Celexa), fluoxetine (Prozac, Sarafem, Selfemra, in Symbyax), fluvoxamine (Luvox), paroxetine (Brisdelle, Paxil, Pexeva), and sertraline (Zoloft), as well as serotonin norepinephrine reuptake inhibitor (Effexor XR). Moreover, let your doctor know if you currently have or have ever had an ulcer, gastrointestinal bleeding, or any other bleeding disorders. Sulindac should be stopped and you should contact your doctor if you suffer any of the following symptoms: stomach pain, heartburn, vomiting of a bloody or coffee-ground-like substance, blood in the stool, or dark, tarry stools.

Keep all of your appointments with your physician and the lab. Your doctor will keep a close eye on your symptoms and most likely prescribe certain tests to determine how your body is reacting to sulindac. Inform your physician about your feelings so that they can prescribe the ideal dosage of medication to cure your problem with the least chance of negative side effects.

If you need a prescription refill for sulindac, your doctor or pharmacist will provide you the manufacturer’s patient information leaflet (Medication Guide). If you have any questions, carefully read the material and contact your doctor or pharmacist. The Medication Guide is also available on the manufacturer’s website or the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm).

Sulindac is used to treat osteoarthritis (arthritis brought on by a breakdown of the lining of the joints), rheumatoid arthritis (arthritis brought on by swelling of the lining of the joints), and ankylosing spondylitis, which all result in pain, tenderness, swelling, and stiffness (arthritis that mainly affects the spine). Sulindac is additionally used to treat shoulder discomfort brought on by tendinitis and bursitis (inflammation of a fluid-filled sac in the shoulder joint) (inflammation of the tissue that connects muscle to bone). It also helps to treat gouty arthritis (attacks of severe joint pain and swelling caused by a build-up of certain substances in the joints). Sulindac belongs to the group of drugs known as NSAIDs. It functions by halting the body’s production of a chemical responsible for inflammation, fever, and discomfort.

Sulindac is available as an oral tablet. It is typically taken twice daily with food. Sulindac should be taken daily at roughly the same time. Ask your doctor or pharmacist to explain any instructions on your prescription label that you are unsure about following. Sulindac must be taken as prescribed. Never take it in larger or less amounts or more frequently than directed by your doctor.

Sulindac aids in managing arthritic pain but does not treat the condition. Sulindac may take up to a week or more to fully take effect if you are using it to relieve arthritis pain.

Patients with familial adenomatous polyposis may also use sulindac to lessen the amount of polyps (abnormal growths) in the colon (large intestine) and rectum (a condition in which hundreds or thousands of polyps form in the colon and cancer may develop). The dangers of using this drug for your illness should be discussed with your doctor.

Ask your doctor or pharmacist for more details if you’re interested in using this drug for any other conditions.

Before taking sulindac,

• Inform your doctor and pharmacist if you have any drug allergies, including those to sulindac, aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn), or any other NSAIDs. Get a list of the inactive components from your pharmacist.
• Inform your doctor and pharmacist about all prescription and over-the-counter drugs, vitamins, dietary supplements, and herbal products that you are now taking or intend to use. Make careful to bring up any of the following, along with any of the medications indicated in the IMPORTANT WARNING section: A number of angiotensin-converting enzyme (ACE) inhibitors, include benazepril (Lotensin, in Lotrel), captopril, enalapril (Vasotec, in Vaseretic), fosinopril, lisinopril (in Zestoretic), moexipril (Univasc), perindopril (Aceon, in Prestalia), and quinapril (Accupril, in Quinaretic), Ramipril (Altace), trandolapril (Mavik, in Tarka), and angiotensin II receptor antagonists such candesartan (Atacand, in Atacand HCT), eprosartan (Teveten), irbesartan (Avapro, in Avalide), losartan (Cozaar, in Hyzaar), and olmesartan (Cozaar, in Hyza (Benicar, in Azor, in Benicar HCT, in Tribenzor),
  cyclosporine (Gengraf, Neoral, Sandimmune), diuretics (often known as “water pills”), lithium (Lithobid), methotrexate (Otrexup, Rasuvo, Trexall), telmisartan (Micardis, in Twynsta), valsartan (in Exforge HCT), probenecid, and oral diabetes medicines (Probalan).
• Inform your doctor if you have or have ever had any of the ailments listed in the IMPORTANT WARNING section, as well as asthma, particularly if you also suffer from frequent stuffy or runny noses, nasal polyps (swelling of the nose’s lining), heart failure, kidney stones, swollen hands, arms, feet, ankles, or lower legs, or liver or kidney disease.
• Inform your doctor if you are expecting, intend to get pregnant, or are nursing a baby. If sulindac is consumed after 20 weeks of pregnancy, it could harm the foetus and complicate delivery. Sulindac should not be taken during or after the first 20 weeks of pregnancy unless your doctor specifically instructs you to. Call your doctor if you become pregnant while taking sulindac.
• If you are 75 years of age or older, discuss the advantages and disadvantages of taking sulindac with your doctor. Never use this medication for a longer time or at a greater dose than what your doctor has prescribed.
• You should let your doctor or dentist know if you are taking sulindac if you are having surgery, including dental surgery.

Keep eating normally unless your doctor instructs you otherwise.

If you miss a dosage, take it as soon as you recall. If the next dose is soon due, skip the missed one and carry on with your regular dosing plan. To make up for a missing dose, do not take a second one.

Sulindac could have negative effects. If any of these symptoms are severe or do not go away, let your doctor know right once:

• Headache
• Dizziness
• Nervousness
• Diarrhea
• Constipation
• Gas
• Hearing ringing

Some adverse effects may be severe. Call your doctor right away if you notice any of the symptoms listed below or those described in the IMPORTANT CAUTION section. Until you speak with your doctor, stop taking sulindac:

• Rise in weight without cause
• Respiratory issues or lack of breath
• Abdomen, lower legs, or foot and ankles swelling
• Fever
• Chills
• Cough
• Sweating
• Flushing
• Joint or muscle ache
• Chest ache
• Blisters
• Rash
• Itching
• Hives
• Swelling of the hands, arms, hands, cheeks, lips, tongue, throat, or eyes.
• Having trouble swallowing
• Hoarseness
• Light skin
• Rapid heart rate
• Extreme fatigue
• Uncommon bruising or bleeding
• Not enough energy
• Uneasy stomach
• Reduced appetite
• Stomach ache in the top right corner
• Flu-like signs
• Eyes or skin that have a yellow tint
• Urine that is hazy, discoloured, or bloody
• Back ache
• Uncomfortable or challenging urinating
• Distorted eyesight or other vision issues

Sulindac may have other negative effects. If you experience any strange issues while taking this medicine, contact your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

Keep this medication tightly closed in the original container and out of the reach of children. Keep it away from excessive heat and moisture at room temperature (not in the bathroom).

Although many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for young children to open, it is crucial to keep all medications out of sight and out of reach of children. Always lock safety caps and promptly stash medication up and away from young children where it is out of their sight and reach to prevent poisoning. http://www.upandaway.org

Unused prescriptions must be disposed of carefully to prevent pets, kids, and other people from ingesting them. You should not, however, dispose of this medication in the toilet. Instead, utilising a medicine take-back programme is the easiest approach to get rid of your medication. To find out about take-back programmes in your area, speak with your pharmacist or the garbage/recycling department in your city. If you do not have access to a take-back programme, see the FDA’s Safe Disposal of Medications website at http://goo.gl/c4Rm4p for additional information.

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Moreover, information can be found online at https://www.poisonhelp.org/help. Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

Symptoms of overdose may include the following:

• Consciousness is lost
• Fainting
• Dizziness
• Fuzzy vision
• Uneasy stomach
• Less urinations

No one else should take your medication. Any queries you may have regarding medication refills should be directed to your pharmacist.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.