WARNING

Clinoril (Generic Sulindac) is a nonsteroidal anti-inflammatory drug (NSAID) used primarily to reduce pain and inflammation in conditions like arthritis. Like all NSAIDs, it carries certain risks that patients should be aware of:

• Gastrointestinal Effects: NSAIDs can irritate the stomach lining, leading to ulcers or bleeding. This risk increases with higher doses and prolonged use.
• Cardiovascular Risks: Long-term use of NSAIDs, including Clinoril, may increase the risk of heart attack or stroke, especially in individuals with pre-existing cardiovascular conditions.
• Kidney Function: NSAIDs can affect kidney function, potentially leading to fluid retention, high blood pressure, or kidney damage, particularly in individuals with compromised kidney function.
• Allergic Reactions: Although rare, some individuals may experience allergic reactions to NSAIDs, ranging from mild skin reactions to severe anaphylaxis.
• Liver Effects: Liver toxicity is possible with NSAID use, although it is uncommon.
• Interaction with other Medications: NSAIDs can interact with other medications, including blood thinners and certain blood pressure medications, potentially altering their effects or causing adverse reactions.
• Other Side Effects: Common side effects include nausea, headache, dizziness, and gastrointestinal discomfort.

It’s essential for patients to use Clinoril under medical supervision, following prescribed dosages and duration to minimize these risks. Regular monitoring and reporting any unusual symptoms to a healthcare provider are crucial when taking Clinoril or any NSAID.

Why is this medication prescribed?

Clinoril (Generic Sulindac) is prescribed primarily for its anti-inflammatory and analgesic (pain-relieving) properties. It is typically used to treat conditions such as:

• Arthritis: Clinoril is commonly prescribed for the relief of symptoms associated with osteoarthritis, rheumatoid arthritis, and other forms of inflammatory arthritis. It helps reduce pain, swelling, and stiffness in the joints.
• Acute Gout: It can be used to manage acute attacks of gout by reducing inflammation and pain associated with this condition.

How should this medicine be used?

Clinoril should be used exactly as prescribed by a healthcare provider. Here are general guidelines for its use:

• Dosage: The dosage of Clinoril varies depending on the condition being treated and the individual patient’s response. It’s important to follow the prescribed dosage instructions carefully.
• Administration: It is usually taken orally, typically once or twice a day with food or milk to minimize stomach upset. Taking it with a full glass of water is recommended.
• Duration: Clinoril is often prescribed for short-term relief of symptoms or for longer periods in chronic conditions like arthritis. The duration of use should be determined by a healthcare provider based on the patient’s response and the condition being treated.
• Monitoring: Regular monitoring by a healthcare provider is important to assess the effectiveness of Clinoril and to watch for any potential side effects or complications.
• Special Instructions: Patients should not exceed the prescribed dosage or duration of use unless directed by their healthcare provider. It’s also essential to avoid alcohol consumption while taking Clinoril, as it can increase the risk of stomach bleeding.
• Adverse Effects: If any adverse effects occur, such as stomach pain, black stools, chest pain, shortness of breath, or signs of an allergic reaction (e.g., rash, swelling), medical attention should be sought immediately.

In summary, Clinoril is used to treat arthritis and acute gout by reducing inflammation and pain. It should be used cautiously under medical supervision to maximize benefits while minimizing potential risks and side effects.

Other uses for this medicine

• Familial Adenomatous Polyposis (FAP): Clinoril has been studied for its potential role in reducing the number and size of adenomatous polyps in patients with FAP, a genetic condition that predisposes individuals to colon cancer.
• Cancer Prevention: Some research suggests that NSAIDs like Clinoril may have a role in reducing the risk of certain cancers, though more studies are needed to confirm this potential benefit.

What special precautions should I follow?

Special Precautions for Using Clinoril:

• Gastrointestinal Effects: NSAIDs, including Clinoril, can cause stomach irritation, ulcers, or bleeding. To reduce this risk, Clinoril should be taken with food, milk, or antacids. Avoiding alcohol and smoking can also help minimize gastrointestinal side effects.
• Cardiovascular Risks: Long-term use of Clinoril may increase the risk of heart attack or stroke, especially in patients with pre-existing heart disease. It’s important to use the lowest effective dose for the shortest duration possible to minimize this risk.
• Kidney Function: NSAIDs can affect kidney function, especially in patients with underlying kidney disease or dehydration. Regular monitoring of kidney function tests is recommended during prolonged use of Clinoril.
• Liver Function: Although rare, Clinoril can potentially cause liver toxicity. Liver function tests may be performed periodically, especially with long-term use.
• Allergic Reactions: Patients should be monitored for signs of allergic reactions, such as rash, itching, swelling, dizziness, or difficulty breathing. Immediate medical attention should be sought if any of these symptoms occur.
• Other Medical Conditions: Inform your healthcare provider if you have a history of asthma, high blood pressure, heart disease, gastrointestinal disorders, kidney disease, or liver disease before starting Clinoril. Adjustments to treatment may be necessary based on these conditions.
• Drug Interactions: Clinoril can interact with other medications, including blood thinners (e.g., warfarin), other NSAIDs, corticosteroids, and certain antidepressants. Always inform your healthcare provider about all medications you are taking to avoid potential interactions.
• Pregnancy and Breastfeeding: Clinoril should be avoided during the third trimester of pregnancy due to potential harm to the unborn baby. It may also pass into breast milk, so it’s generally recommended to avoid using it while breastfeeding.

While Clinoril is primarily used for arthritis and acute gout, it has been explored for other conditions like FAP and cancer prevention. However, it carries significant risks and requires careful monitoring and adherence to precautions to ensure safe use. Always follow your healthcare provider’s instructions closely and report any concerning symptoms promptly.

What special dietary instructions should I follow?

There are no specific dietary restrictions for Clinoril. However, certain dietary practices can help minimize gastrointestinal side effects:

• Take Clinoril with food, milk, or antacids to protect your stomach lining.
• Avoid alcohol and smoking, as they can increase the risk of stomach irritation and bleeding.

What should I do if I forget a dose?

If you miss a dose of Clinoril, take it as soon as you remember, unless it is almost time for your next scheduled dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not double up on doses to make up for a missed one.

What side effects can this medication cause?

Clinoril (Generic Sulindac), like other nonsteroidal anti-inflammatory drugs (NSAIDs), can cause a range of side effects. It’s important to note that not everyone will experience these side effects, and their severity can vary. Common side effects of Clinoril include:

• Gastrointestinal Effects: These are among the most common side effects and can include stomach pain, heartburn, nausea, vomiting, indigestion, and diarrhea. NSAIDs like Clinoril can also cause more serious gastrointestinal issues such as ulcers or bleeding, which may not always produce symptoms right away.
• Cardiovascular Effects: Long-term use of Clinoril may increase the risk of heart attack or stroke, particularly in individuals with pre-existing cardiovascular conditions or those at high risk.
• Kidney Effects: NSAIDs can affect kidney function, potentially leading to fluid retention, high blood pressure, or kidney damage, especially in individuals with compromised kidney function.
• Liver Effects: While rare, Clinoril can cause liver toxicity, which may manifest as jaundice (yellowing of the skin or eyes), dark urine, or persistent fatigue.
• Allergic Reactions: Some individuals may experience allergic reactions to Clinoril, ranging from mild skin reactions (rash, itching) to more severe reactions such as swelling of the face, throat, or tongue, which require immediate medical attention.
• Central Nervous System Effects: These can include headache, dizziness, drowsiness, and in rare cases, confusion or hallucinations.
• Blood Disorders: Clinoril may affect blood clotting, leading to increased bleeding time or bruising.
• Other Effects: Less common side effects can include ringing in the ears (tinnitus), changes in vision, weight gain, and fluid retention.

It’s important to seek medical attention if you experience severe side effects or any unusual symptoms while taking Clinoril. To minimize these risks, Clinoril should be used at the lowest effective dose for the shortest possible duration, and individuals should be monitored regularly by their healthcare provider.

What should I know about storage and disposal of this medication?

Storage and Disposal of Clinoril:

• Storage: Store Clinoril tablets at room temperature, away from moisture and heat. Keep it in the original container with the lid tightly closed. Avoid storing it in the bathroom.
• Disposal: Dispose of Clinoril properly to prevent accidental ingestion by children, pets, or others. Follow any specific disposal instructions provided by your pharmacist or local waste disposal company. Do not flush Clinoril down the toilet unless instructed to do so.

In case of emergency/overdose

• Symptoms of Overdose: Symptoms of Clinoril overdose may include severe stomach pain, vomiting blood, shallow breathing, fainting, or coma.
• Immediate Action: If you suspect an overdose or experience severe symptoms after taking Clinoril, seek emergency medical attention or contact your local poison control center immediately (in the US, you can call 1-800-222-1222).
• Information to Provide: Provide information such as the amount of Clinoril ingested, when it was taken, and any other relevant details about your condition.

What other information should I know?

• Regular Monitoring: Your healthcare provider may periodically monitor your kidney function, liver function, and blood pressure while you are taking Clinoril.
• Avoid Alcohol: Alcohol can increase the risk of stomach bleeding when taken with Clinoril. It’s best to avoid alcohol consumption while using this medication.
• Avoid Other NSAIDs: Do not take other NSAIDs (such as ibuprofen, naproxen) while using Clinoril unless specifically instructed by your healthcare provider.
• Pregnancy and Breastfeeding: Clinoril should generally be avoided during the third trimester of pregnancy due to potential harm to the unborn baby. It may also pass into breast milk, so it’s typically recommended to avoid using it while breastfeeding.
• Allergic Reactions: Be aware of signs of allergic reactions (e.g., rash, itching, swelling of the face/tongue/throat, severe dizziness) and seek immediate medical attention if they occur.
• Medical Alerts: Make sure to inform all healthcare providers (doctors, dentists, pharmacists) about your use of Clinoril before receiving any new treatment or procedure.
• Follow Instructions: Follow your healthcare provider’s instructions carefully regarding the use of Clinoril, including dosage adjustments and any special precautions based on your medical history.

Understanding and following these guidelines can help ensure the safe and effective use of Clinoril while minimizing potential risks and complications.