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Citrovorum Factor (Generic Leucovorin Injection)

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Why is this medication prescribed?

When methotrexate (Rheumatrex, Trexall; a chemotherapy drug for cancer) is used to treat some types of cancer, leucovorin injection is used to lessen any negative effects. Treatment for those who unintentionally took an excessive amount of methotrexate or a comparable drug is with leucovorin injection. As a treatment for anaemia (low red blood cell count), leucovorin injection is also used to treat folic acid deficiency-related anaemia. The chemotherapeutic drug 5-fluorouracil is also used with leucovorin injection to treat colorectal cancer (cancer that begins in the large intestine). Among the category of drugs known as folic acid analogues is leucovorin injection. By shielding healthy cells from the side effects of methotrexate, it treats patients who are receiving the drug. By providing folic acid, which is necessary for the production of red blood cells, it relieves anaemia. It increases the effects of 5-fluorouracil in the treatment of colorectal cancer.

How should this medicine be used?

Injections of leucovorin are available as a liquid solution and a powder that must be combined with liquid before being injected intravenously (into a vein) or into a muscle. Leucovorin injection is typically administered every 6 hours until laboratory tests indicate it is no longer required to treat a methotrexate overdose or prevent its adverse effects. Leucovorin injection is typically administered once day to treat anaemia. Leucovorin injection is typically administered once daily for five days as part of a treatment that may be repeated once every 4 to 5 weeks to treat colorectal cancer.

Other uses for this medicine

Ask your doctor or pharmacist for more details if you believe this drug should be used for something else.

What special precautions should I follow?

Before receiving leucovorin injection,

  • If you have an allergy to leucovorin, levoleucovorin, folic acid (Folicet, in multivitamins), or any other drugs, tell your doctor right away.
  • Inform your doctor and pharmacist about all prescription and over-the-counter drugs, vitamins, dietary supplements, and herbal products that you are now taking or intend to use. Mention any of the following: trimethoprim-sulfamethoxazole, phenobarbital, phenytoin (Dilantin), primidone (Mysoline), and other drugs used to treat seizures (Bactrim, Septra). Your physician might need to adjust the dosage of your drugs or keep a close eye on you for side effects.
  • Inform your physician if you develop anaemia (low red blood cell count) brought on by a shortage of vitamin B12 or a problem with vitamin B12 absorption. For the treatment of this kind of anaemia, your doctor won’t recommend leucovorin injection.
  • Inform your doctor if you have or have ever had renal disease, cancer that has spread to your brain or nervous system, a buildup of fluid in your chest or stomach, or any of these conditions.
  • Inform your doctor if you are expecting, intend to get pregnant, or are nursing a baby. Call your doctor if you fall pregnant while taking a leucovorin injection.

What special dietary instructions should I follow?

Keep eating normally unless your doctor instructs you otherwise.

What side effects can this medication cause?

Some adverse effects may be severe. Call your doctor right away if you notice any of these signs:

  • Seizures
  • Fainting
  • Diarrhea
  • Rash
  • Hives
  • Itching
  • Breathing or swallowing challenges

Further negative effects from leucovorin injection are possible. If you have any strange side effects while taking this medicine, call your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online (http://www.fda.gov/Safety/MedWatch) or by phone if you have a serious side event (1-800-332-1088).

In case of emergency/overdose

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Moreover, information can be found online at https://www.poisonhelp.org/help. Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

What other information should I know?

Keep all of your appointments with your physician and the lab. To monitor your body’s reaction to the leucovorin injection, your doctor will request a few lab tests.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Wellcovorin® I.V.
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