Why is this medication prescribed?

Cinvanti (aprepitant) is prescribed to prevent nausea and vomiting caused by chemotherapy, particularly in patients receiving moderately or highly emetogenic (nausea-inducing) chemotherapy regimens. It is used in combination with other antiemetic medications to provide effective prevention of chemotherapy-induced nausea and vomiting (CINV).

How should this medicine be used?

Here are some general guidelines for using Cinvanti:

• Dosage Form: Cinvanti is typically administered as an intravenous (IV) infusion.
• Administration: It is usually given over 30 minutes, starting at least 30 minutes before chemotherapy.
• Combination Therapy: Cinvanti is often used in combination with a 5-HT3 receptor antagonist (such as ondansetron) and dexamethasone.
• Dosage: The dosage can vary depending on the specific chemotherapy regimen and the patient’s individual factors. It is important to follow the exact dosage and administration schedule prescribed by the healthcare provider.
• Follow-Up: Patients may receive Cinvanti on the day of chemotherapy and potentially for a few days afterward, depending on the specific chemotherapy regimen and the risk of delayed nausea and vomiting.
• Instructions: Always follow the healthcare provider’s instructions regarding the preparation, administration, and timing of Cinvanti to ensure optimal effectiveness in preventing CINV.

It’s crucial for patients to communicate any side effects or concerns to their healthcare provider promptly while using Cinvanti. This helps in managing any potential adverse effects and ensuring the best outcome in controlling chemotherapy-induced nausea and vomiting.

Other uses for this medicine

Cinvanti (aprepitant) is primarily used for preventing chemotherapy-induced nausea and vomiting (CINV). Apart from its primary use, there are no widely recognized alternative medical uses for Cinvanti that are approved by regulatory authorities. It is specifically designed and approved for managing nausea and vomiting associated with chemotherapy.

What special precautions should I follow?

Special Precautions for Cinvanti:

• Allergic Reactions: Inform your healthcare provider if you have had any allergic reactions to aprepitant or any other medications. This is important because allergic reactions can occur, although they are rare.
• Liver Function: Cinvanti is metabolized in the liver, so patients with pre-existing liver conditions should be monitored closely. Your healthcare provider may adjust the dosage or consider alternative medications if you have significant liver impairment.
• Drug Interactions: Cinvanti can interact with other medications, including certain anticoagulants (blood thinners) and medications that are metabolized through the same liver enzymes. Make sure to inform your healthcare provider about all medications, supplements, and herbal products you are taking to avoid potential interactions.
• Pregnancy and Breastfeeding: The safety of Cinvanti during pregnancy and breastfeeding has not been established. It is important to discuss with your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding.
• Children and Elderly: Safety and effectiveness of Cinvanti in pediatric patients (under 18 years old) and elderly patients (over 65 years old) have not been established thoroughly. Use in these populations should be based on careful consideration of potential risks and benefits.
• Side Effects: Like all medications, Cinvanti can cause side effects. Common side effects include fatigue, diarrhea, headache, and changes in liver function tests. Notify your healthcare provider if you experience any unusual symptoms while taking Cinvanti.
• Administering the Medication: Cinvanti is administered intravenously (IV) in a healthcare setting. It should be given by a healthcare professional who is trained in its administration to ensure safety and proper dosing.

Always follow your healthcare provider’s instructions regarding the use of Cinvanti and discuss any questions or concerns you may have about its use and potential side effects. Regular monitoring and communication with your healthcare team are essential for optimizing your treatment and managing any potential issues effectively.

What special dietary instructions should I follow?

There are no specific dietary restrictions associated with Cinvanti. However, maintaining a balanced diet and adequate hydration can help support your overall health during chemotherapy treatment. It’s essential to follow any dietary advice provided by your healthcare team, especially if you have specific dietary needs or restrictions due to other medical conditions.

What should I do if I forget a dose?

If you miss a dose of Cinvanti, contact your healthcare provider or infusion center as soon as possible for guidance. It is essential to maintain the recommended schedule for Cinvanti administration to effectively prevent chemotherapy-induced nausea and vomiting (CINV).

In general, do not try to make up for a missed dose on your own or take extra doses unless instructed to do so by your healthcare provider. They may provide specific instructions on how to proceed based on your treatment schedule and individual circumstances.

What side effects can this medication cause?

Cinvanti (aprepitant) can cause various side effects, although not everyone experiences them. Common side effects may include:

• Fatigue: Feeling tired or lacking energy.
• Nausea and/or Vomiting: Ironically, nausea can be a side effect of Cinvanti itself, though usually mild compared to chemotherapy-induced nausea.
• Dizziness: Feeling lightheaded or unsteady.
• Diarrhea: Increased frequency of bowel movements with loose, watery stools.
• Headache: Pain or discomfort in the head, ranging from mild to severe.
• Hiccups: Involuntary contractions of the diaphragm that cause sudden inhalation with a distinctive sound.
• Changes in Liver Function Tests: Cinvanti can affect liver enzymes, which may be monitored through blood tests.
• Injection Site Reactions: Redness, swelling, or discomfort at the site where the medication was administered intravenously.

Less common but potentially more serious side effects include allergic reactions such as rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, or trouble breathing. If you experience any of these symptoms, seek immediate medical attention.

It’s important to note that the side effects of Cinvanti can vary from person to person, and not everyone will experience all of these effects. Your healthcare provider can provide more information about potential side effects specific to your situation and how to manage them effectively during your treatment. Regular communication with your healthcare team is essential for monitoring and addressing any side effects that may arise.

What should I know about storage and disposal of this medication?

Storage and Disposal of Cinvanti:

• Storage: Cinvanti should be stored at room temperature, between 20°C to 25°C (68°F to 77°F). It should be protected from light and kept in its original packaging until ready for use.
• Handling: Healthcare professionals should handle Cinvanti according to safe handling guidelines, as it is administered intravenously. Proper aseptic techniques should be used during preparation and administration to minimize the risk of contamination.
• Disposal: Any unused portion of Cinvanti or materials used in the preparation and administration should be disposed of properly according to local regulations for hazardous waste disposal. It’s important not to dispose of medications through wastewater or household waste unless specifically instructed to do so.

In case of emergency/overdose

• Symptoms: In case of an overdose or emergency situation, symptoms may include severe dizziness, drowsiness, and possibly fainting.
• Immediate Action: If you suspect an overdose or experience severe symptoms, seek immediate medical attention. Contact your local poison control center or emergency room for further guidance.

What other information should I know?

• Effectiveness: Cinvanti is most effective when used as prescribed, typically starting at least 30 minutes before chemotherapy and possibly continuing for several days afterward, depending on your treatment plan.
• Follow-Up: Keep all scheduled appointments with your healthcare provider for monitoring and evaluation during and after treatment with Cinvanti.
• Communication: Inform your healthcare provider about any medications (prescription, over-the-counter, or herbal supplements) you are taking, as well as any allergies or medical conditions you have, before starting Cinvanti.
• Side Effects: Be aware of potential side effects and report any unusual symptoms or concerns to your healthcare provider promptly.
• Storage and Handling: Store Cinvanti securely away from children and pets. Avoid exposing it to extreme temperatures or direct sunlight.

By following these guidelines for storage, disposal, handling emergencies, and understanding other important information, you can help ensure safe and effective use of Cinvanti as part of your chemotherapy treatment regimen. Always consult your healthcare provider if you have any questions or need further clarification about your medication.