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Cinacalcet

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Why is this medication prescribed?

Patients with chronic kidney disease (a condition in which the kidneys stop working slowly and gradually) who are receiving dialysis are treated with cinacalcet to treat secondary hyperparathyroidism (a condition in which the body produces too much parathyroid hormone [a natural substance needed to control the amount of calcium in the blood], which can cause serious problems with the bones, heart, blood vessels, and lungs]) (medical treatment to clean the blood when the kidneys are not working properly). Patients with parathyroid carcinoma who have excessive blood calcium levels can also be treated with cinacalcet (cancer of the glands in the neck that make parathyroid hormone). Cinacalcet belongs to the group of drugs known as calcimimetics. In order to lower the level of calcium in the blood, it signals the body to create less parathyroid hormone.

How should this medicine be used?

Cinacalcet is available as an oral tablet. Typically, it is taken once day with food or immediately after eating. Take your cinacalcet at roughly the same time each day to help you remember to take it. Ask your doctor or pharmacist to explain any instructions on your prescription label that you are unsure about following. Use Cinacalcet as prescribed by your doctor. Never take it in larger or less amounts or more frequently than directed by your doctor.

Do not chew, break, or crush the tablets; instead, swallow them whole.

Your physician will likely start you on a modest dose of cinacalcet and progressively increase it, not more frequently than once every two to four weeks.

Your problem won’t be cured with cinacalcet, but it might help you manage it. Even if you feel well, keep taking Cinacalcet. Without consulting your doctor, do not discontinue taking cinacalcet.

Other uses for this medicine

Ask your doctor or pharmacist for more details if you believe this drug should be used for something else.

What special precautions should I follow?

Before taking cinacalcet,

  • If you have an allergy to cinacalcet or any other drug, let your doctor and pharmacist know right away.
  • Inform your physician and pharmacist about all prescription and over-the-counter drugs, vitamins, dietary supplements, and herbal products you are taking. Incorporate any of the following: Amitriptyline (Elavil), clomipramine (Anafranil), desipramine (Norpramin), and fluoxetine are antidepressants (mood elevators) (Prozac, Sarafem), antifungal medications like fluconazole (Diflucan), itraconazole (Sporanox), and ketoconazole (Nizoral); nefazodone, nortriptyline (Aventyl, Pamelor), paroxetine (Paxil), protriptyline (Vivactil), and trimipramine (Surmontil); cimetidine (Tagamet); and cyclosporine (Neoral, Sandimmune); erythromycin (E.E.S., E-Mycin, Erythrocin), flecainide (Tambocor), danazol (Danocrine), delavirdine (Rescriptor), diltiazem (Cardizem, Dilacor, Tiazac), erythromycin, HIV protease inhibitors such as indinavir (Crixivan) and ritonavir (Norvir); oral contraceptives (birth control pills), vinblastine (Velban), thioridazine (Mellaril), troleandomycin (TAO), verapamil (Calan, Covera, Isoptin, Verelan), and zafirlukast (Accolate). Your doctor might need to adjust your medication doses or keep a close eye out for any negative side effects.
  • Inform your doctor if you suffer from liver disease or have ever experienced seizures.
  • Inform your doctor if you are expecting, intend to get pregnant, or are nursing a baby. Call your doctor if you become pregnant while taking Cinacalcet.

What special dietary instructions should I follow?

If you plan to consume grapefruit juice while taking this medicine, consult your doctor.

What should I do if I forget a dose?

If you miss a dosage, take it as soon as you recall. If the next dose is soon due, skip the missed one and carry on with your regular dosing plan. To make up for a missing dose, do not take a second one.

What side effects can this medication cause?

Cinacalcet could have negative effects. If any of these symptoms are severe or do not go away, let your doctor know right once:

  • Upset stomach
  • Vomiting
  • Diarrhea
  • Dizziness
  • Weakness
  • Chest ache

Certain adverse effects can be very harmful. Even though the following signs are unusual, you should call your doctor right once if you notice any of them:

  • Feelings of the lips, tongue, fingers, or feet that are burning, tingling, or strange
  • Muscular pain or cramping
  • Abrupt tenseness in the hands, foot, face, or throat muscles
  • Seizures
  • Access to dialysis infected (surgically created blood vessel where blood leaves and enters the body during dialysis)

Further negative effects of cinacalcet are possible. If you experience any strange issues while taking this medicine, contact your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

What should I know about storage and disposal of this medication?

Keep this medication tightly closed in the original container and out of the reach of children. Keep it away from excessive heat and moisture at room temperature (not in the bathroom).

Unused prescriptions must be disposed of carefully to prevent pets, kids, and other people from ingesting them. You should not, however, dispose of this medication in the toilet. Instead, utilising a medicine take-back programme is the easiest approach to get rid of your medication. To find out about take-back programmes in your area, speak with your pharmacist or the garbage/recycling department in your city. If you do not have access to a take-back programme, see the FDA’s Safe Disposal of Medications website at http://goo.gl/c4Rm4p for additional information.

Although many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for young children to open, it is crucial to keep all medications out of sight and out of reach of children. Always lock safety caps and promptly stash medication up and away from young children where it is out of their sight and reach to prevent poisoning. http://www.upandaway.org

In case of emergency/overdose

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Moreover, information can be found online at https://www.poisonhelp.org/help. Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

Overdose symptoms could include:

  • Feelings of the lips, tongue, fingers, or feet that are burning, tingling, or strange
  • Muscular pain or cramping
  • Abrupt tenseness in the hands, foot, face, or throat muscles
  • Seizures

What other information should I know?

Keep all of your appointments with your physician and the lab. To monitor your body’s reaction to cinacalcet, your doctor will request specific lab tests.

No one else should take your medication. Any queries you may have regarding medication refills should be directed to your pharmacist.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Sensipar®
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