WARNING

Taking Cibinqo (Abrocitinib) carries several risks that patients should be aware of:

• Infections: Abrocitinib can increase the risk of infections, including upper respiratory tract infections and serious infections like pneumonia or skin infections. Patients should monitor for signs of infection and report them promptly to their healthcare provider.
• Liver Problems: Some patients may experience elevated liver enzymes, which can indicate liver inflammation. Regular monitoring of liver function may be necessary during treatment.
• Allergic Reactions: Although rare, allergic reactions to Abrocitinib can occur. Symptoms may include rash, itching, swelling, severe dizziness, or difficulty breathing. Immediate medical attention is necessary if these occur.
• Serious Skin Conditions: There is a potential risk of developing serious skin conditions, including skin cancers. Patients should undergo regular skin examinations during treatment.
• Pregnancy and Breastfeeding: The safety of Abrocitinib during pregnancy and breastfeeding is not fully established. Healthcare providers should carefully weigh the potential benefits and risks before prescribing to pregnant or nursing women.
• Other Side Effects: Common side effects include headache, nausea, fatigue, diarrhea, and herpes simplex infections. These side effects are generally mild to moderate in severity.

Patients considering Abrocitinib should discuss these risks with their healthcare provider to determine if the benefits of treatment outweigh the potential risks in their individual case. Regular monitoring and adherence to medical advice can help manage these risks effectively.

Why is this medication prescribed?

Cibinqo (Abrocitinib) is prescribed primarily for the treatment of moderate to severe atopic dermatitis (eczema) in adults who are candidates for systemic therapy. Atopic dermatitis is a chronic inflammatory skin condition characterized by itching, redness, and skin lesions.

Cibinqo is prescribed because it specifically targets certain molecules involved in the inflammatory process underlying atopic dermatitis. By inhibiting these molecules, Cibinqo helps to reduce inflammation and alleviate the symptoms associated with moderate to severe eczema, such as itching and skin lesions.

How should this medicine be used?

Here’s how Cibinqo should be used:

• Dosage: The dosage of Cibinqo will depend on the specific formulation prescribed by your healthcare provider. It typically comes in tablet form.
• Administration: Usually taken orally with or without food, as directed by your doctor.
• Compliance: Follow your doctor’s instructions carefully regarding dosage and frequency. Do not adjust the dose or stop taking Cibinqo without consulting your doctor first.
• Monitoring: Regular monitoring of cholesterol levels and other relevant parameters may be necessary while taking Cibinqo.
• Side effects: Be aware of potential side effects and report any unusual symptoms to your healthcare provider promptly.

It’s important to note that Cibinqo should only be taken under the supervision and guidance of a healthcare professional who can assess your individual medical condition and ensure it is appropriate for you.

Other uses for this medicine

Aside from its primary uses for improving symptoms of intermittent claudication and lowering cholesterol levels, Cibinqo may have other potential uses or benefits under medical supervision. However, the primary indications mentioned earlier are the most widely recognized uses for this medication.

What special precautions should I follow?

Special Precautions for Cibinqo:

• Allergies: Inform your healthcare provider if you have any allergies to Cibinqo, or any other medications.
• Medical History: Provide a detailed medical history, especially if you have a history of liver disease, kidney disease, or any other serious health conditions.
• Pregnancy and Breastfeeding: Cibinqo should not typically be used during pregnancy unless clearly necessary and prescribed by a doctor. It is important to discuss the risks and benefits with your healthcare provider if you are pregnant or planning to become pregnant. Similarly, breastfeeding while taking Cibinqo is generally not recommended; discuss with your doctor.
• Drug Interactions: Inform your doctor about all medications, vitamins, and supplements you are currently taking, as Cibinqo can interact with certain medications, including other cholesterol-lowering medications, blood thinners, and certain antibiotics.
• Liver Function: Regular monitoring of liver function may be necessary while taking Cibinqo, especially if you have a history of liver problems.
• Muscle Pain: Statins like Atorvastatin can sometimes cause muscle pain or weakness. If you experience unexplained muscle pain, tenderness, or weakness, especially if accompanied by fever or feeling unwell, contact your doctor immediately.
• Alcohol: Limit alcohol consumption while taking Cibinqo, as excessive alcohol can increase the risk of liver problems and other side effects.
• Routine Monitoring: Regular check-ups with your healthcare provider are important to monitor your response to treatment, including cholesterol levels, liver function, and overall health.

Always follow your doctor’s instructions carefully regarding the use of Cibinqo, including dosage and any specific precautions based on your individual health profile. If you have any concerns or experience any unusual symptoms while taking Cibinqo, do not hesitate to contact your healthcare provider promptly.

What special dietary instructions should I follow?

• Grapefruit: Avoid consuming grapefruit or grapefruit juice while taking Cibinqo, as it can increase the levels of Atorvastatin in your blood and potentially increase the risk of side effects.
• Cholesterol-lowering Diet: Your doctor may recommend following a healthy diet low in saturated fats, cholesterol, and trans fats. This diet can help enhance the effectiveness of Atorvastatin in lowering cholesterol levels.

What should I do if I forget a dose?

• If you miss a dose of Cibinqo, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule.
• Do not take a double dose to make up for a missed one.
• If you are unsure about what to do, or if you frequently forget doses, consult your healthcare provider or pharmacist for advice on how to manage missed doses effectively.

What side effects can this medication cause?

Cibinqo (generic name Abrocitinib) is a medication used to treat moderate to severe atopic dermatitis (eczema) in adults who are eligible for systemic therapy. Like any medication, Abrocitinib can cause side effects, some of which may be common and others less so. Here are potential side effects associated with Abrocitinib:

Common Side Effects:

• Upper respiratory tract infections: Such as colds or sinus infections.
• Headache: Mild to moderate headaches are reported by some users.
• Nausea: Feeling queasy or occasionally vomiting.
• Fatigue: Feeling tired or having less energy.
• Diarrhea: Loose stools or frequent bowel movements.
• Herpes simplex infections: Cold sores or genital herpes flare-ups.

Less Common but Serious Side Effects:

• Increased liver enzymes: Detected through blood tests, indicating possible liver inflammation.
• Serious infections: Such as pneumonia or skin infections, though less frequent.

Allergic Reactions:

• Hypersensitivity: Rare but possible allergic reactions may occur, characterized by rash, itching, swelling, severe dizziness, or difficulty breathing.

Other Considerations:

• Drug interactions: Abrocitinib may interact with other medications or supplements. It’s important to disclose all current medications to your healthcare provider.
• Pregnancy and breastfeeding: Safety data in these populations may be limited, so consult with a healthcare provider if pregnant or nursing.

Always consult with your healthcare provider if you experience any concerning symptoms while taking Abrocitinib. They can provide guidance on managing side effects and determine if the medication is suitable for you.

What should I know about storage and disposal of this medication?

Storage of Cibinqo:

• Store Cibinqo at room temperature, away from excessive heat and moisture.
• Keep it in its original packaging or container to protect it from light.
• Follow any specific storage instructions provided by your pharmacist or healthcare provider.

Disposal of Cibinqo:

• Dispose of unused or expired Cibinqo properly according to local regulations and guidelines.
• Do not flush medications down the toilet or pour them into a drain unless instructed to do so.
• Consult your pharmacist or local waste disposal company for proper disposal methods.

In case of emergency/overdose

• Seek immediate medical attention if you suspect an overdose or experience severe symptoms such as severe dizziness, fainting, difficulty breathing, or loss of consciousness.
• Contact your local poison control center (1-800-222-1222 in the United States) for guidance on what to do in case of overdose.

What other information should I know?

• Regular Monitoring: Your doctor may perform periodic tests to monitor your response to Cibinqo treatment, including liver function tests and cholesterol levels. Follow your doctor’s instructions carefully regarding dosage and schedule for taking Cibinqo.
• Avoid Alcohol: Limit alcohol consumption while taking Cibinqo, as it can increase the risk of liver problems and other side effects.
• Tell Your Doctor: Inform your healthcare provider about all medications, vitamins, and supplements you are taking, as well as any allergies or medical conditions you have.
• Grapefruit Interaction: Avoid consuming grapefruit or grapefruit juice while taking Cibinqo, as it can affect the metabolism of Atorvastatin and increase its levels in the blood, potentially leading to side effects.

It’s crucial to have a clear understanding of how to store, take, and handle Cibinqo properly to ensure its effectiveness and minimize the risk of adverse effects. Always consult your healthcare provider or pharmacist if you have any questions or concerns about your medication regimen.