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Cetuximab Injection

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Cetuximab may cause severe or life-threatening reactions while you receive the medication. These reactions are more common with the first dose of cetuximab but may occur at any time during treatment. Your doctor will watch you carefully while you receive each dose of cetuximab and for at least 1 hour afterward. Tell your doctor if you experience any of the following symptoms during or after your infusion: sudden difficulty breathing, shortness of breath, wheezing or noisy breathing, swelling of the eyes, face, mouth, lips or throat, hoarseness, hives, fainting, dizziness, blurred vision, nausea, fever, chills, or chest pain or pressure. If you experience a severe reaction your doctor will stop your infusion and treat the symptoms of the reaction. You will not be able to receive treatment with cetuximab in the future.

People with a head and neck cancer who are treated with radiation therapy and cetuximab may have an increased risk of cardiopulmonary arrest (condition in which the heart stops beating and breathing stops) and sudden death during or after their treatment. Tell your doctor if you have or have ever had coronary artery disease (condition that occurs when the blood vessels of the heart are narrowed or clogged by fat or cholesterol deposits); heart failure (condition in which the heart is unable to pump enough blood to the other parts of the body); irregular heartbeat; other heart disease; or lower than normal levels of magnesium, potassium, or calcium in your blood.

Keep all appointments with your doctor and the laboratory. Your doctor will order certain tests during and after your treatment to check your body’s response to cetuximab.

Talk to your doctor about the risks of using cetuximab.

Why is this medication prescribed?

Cetuximab is used with or without radiation therapy or other medications to treat a certain type of cancer of the head and neck. Cetuximab is also used alone or in combination with other medications to treat a certain type of cancer of the colon (large intestine) or rectum that has spread to other parts of the body. Cetuximab is in a class of medications called monoclonal antibodies. It works by slowing or stopping the growth of cancer cells.

How should this medicine be used?

Cetuximab comes as a solution (liquid) to be infused (injected slowly) into a vein. Cetuximab is given by a doctor or nurse in a medical office or infusion center. It is usually given once a week.

Other uses for this medicine

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

What special precautions should I follow?

Before receiving treatment with cetuximab,

  • Tell your doctor and pharmacist if you are allergic to cetuximab, or any other medications.
  • Tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take.
  • Tell your doctor if you have or have ever had heart disease.
  • Tell your doctor if you or your partner are pregnant or plan to become pregnant. You or your partner should not become pregnant during your treatment with cetuximab and for at least 6 months after your treatment. Talk to your doctor about birth control methods that you can use during your treatment. . If you or your partner become pregnant while you are receiving cetuximab, call your doctor.
  • Tell your doctor if you are breastfeeding. Your doctor may tell you not to breast-feed during your treatment and for 60 days after you stop receiving this medication.
  • Plan to avoid unnecessary or prolonged exposure to sunlight and to wear protective clothing, a hat, sunglasses, and sunscreen during your treatment with cetuximab and for 2 months after your treatment. .

What special dietary instructions should I follow?

Unless your doctor tells you otherwise, continue your normal diet.

What should I do if I forget a dose?

If you miss an appointment to receive a dose of cetuximab, call your doctor right away.

What side effects can this medication cause?

Cetuximab may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  1. Acne-like rash
  2. Dry or cracking skin
  3. Itching
  4. Swelling, pain, or changes in the fingernails or toenails
  5. Red, watery, or itchy eye(s)
  6. Red or swollen eyelid(s)
  7. Pain or burning sensation in eye(s)
  8. Sensitivity of eyes to light
  9. Hair loss
  10. Increased hair growth on head, face, eyelashes, or chest
  11. Chapped lips
  12. Headache
  13. Tiredness
  14. Weakness
  15. Confusion
  16. Numbness, tingling, pain, or burning in arms or legs
  17. Dry mouth
  18. Sores on lips, mouth, or throat
  19. Sore throat
  20. Vomiting
  21. Change in ability to taste food
  22. Loss of appetite
  23. Weight loss
  24. Constipation
  25. Diarrhea
  26. Heartburn
  27. Joint pain
  28. Bone pain
  29. Pain, redness, or swelling at the place the medication was injected

Some side effects can be serious. If you experience any of these symptoms or those listed in the IMPORTANT WARNING section, call your doctor immediately:

  1. Coughing up blood or dry cough
  2. Shortness of breath, chest pain or unusual tiredness during exercise
  3. Decreased urination
  4. Loss of vision
  5. Blistering, peeling, or shedding skin
  6. Red, swollen, or infected skin

Cetuximab may cause other side effects. Call your doctor if you have any unusual problems while using this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting program online ( or by phone (1-800-332-1088).

In case of emergency/overdose

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at If the victim has collapsed, had a seizure, has trouble breathing, or can’t be awakened, immediately call emergency services at 911.

What other information should I know?

Ask your doctor if you have any questions about your treatment with cetuximab.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Brand names

  • Erbitux®
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