Why is this medication prescribed?

Cefotan, the brand name for cefotetan, is a cephalosporin antibiotic. It is prescribed to treat various bacterial infections, including those of the skin, bone, respiratory tract, urinary tract, and the female reproductive system. Cefotetan works by interfering with the formation of the bacteria’s cell walls, causing the walls to rupture and leading to the death of the bacteria.

How should this medicine be used?

How Cefotan should be used:

• Administration: Cefotan is usually given as an injection, either intravenously (IV) or intramuscularly (IM). The exact dosage and frequency depend on the type and severity of the infection being treated, the patient’s age, weight, kidney function, and response to the medication.
• Dosage: The typical dosage for adults can range from 1 to 2 grams every 12 hours, but this can vary based on the specific infection and patient factors. For surgical prophylaxis, a single dose is usually administered 30 to 60 minutes before the procedure.
• Preparation: The injection solution should be prepared according to the manufacturer’s instructions and should be checked for any particulate matter or discoloration before administration.
• Duration: The duration of treatment varies based on the infection. It’s important to complete the full prescribed course, even if symptoms improve before the medication is finished, to prevent the development of antibiotic-resistant bacteria.
• Monitoring: Patients should be monitored for potential side effects, such as allergic reactions, gastrointestinal disturbances, or signs of a secondary infection. Kidney and liver function may also be monitored during prolonged therapy.
• Storage: Cefotan should be stored as per the manufacturer’s guidelines, usually in a refrigerator, and should be protected from light. Once prepared, the solution’s stability can vary, so it should be used within the recommended time frame.

If you have any specific concerns or conditions, it’s best to consult with a healthcare professional for personalized advice and instructions

Other uses for this medicine

• Surgical Prophylaxis: It can be used to prevent infections in patients undergoing certain types of surgery.
• Infections: Cefotan can be used to treat infections of the respiratory tract, skin, bones, joints, and intra-abdominal infections.

What special precautions should I follow?

Special Precautions for Cefotan:

• Allergies: Inform your doctor if you are allergic to cefotetan, other cephalosporins, penicillins, or any other medications. Allergic reactions can range from mild to severe.
• Medical History: Discuss your medical history, especially:
  • Kidney disease
  • Liver disease
  • Gastrointestinal diseases (e.g., colitis)
  • Bleeding or clotting disorders
• Pregnancy and Breastfeeding: Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Cefotetan should be used during pregnancy only if clearly needed. It is excreted in breast milk, so caution is advised.
• Medication Interactions: Provide a complete list of medications you are taking (prescription, over-the-counter, vitamins, and herbal products) as cefotetan can interact with other drugs, including:
  • Blood thinners (anticoagulants)
  • Other antibiotics
  • Probenecid (used for gout)
• Alcohol Use: Avoid alcohol consumption while on cefotetan and for at least 72 hours after the last dose due to the risk of a disulfiram-like reaction (flushing, headache, nausea, vomiting, and palpitations).
• Laboratory Tests: Cefotetan can interfere with certain lab tests, including urine glucose tests and the Coombs test. Inform laboratory personnel that you are using this medication.
• Monitoring: Regular monitoring of kidney and liver function, blood counts, and coagulation tests is important, especially with prolonged use.
• Diarrhea: Antibiotics like cefotetan can cause a severe intestinal condition (Clostridium difficile-associated diarrhea). If you develop persistent diarrhea, abdominal pain, or blood/mucus in your stool, contact your doctor immediately.
• Administration Site Reactions: Pain, swelling, and redness at the injection site may occur. Inform your healthcare provider if these symptoms persist or worsen.
• Superinfections: Prolonged use may result in secondary infections (e.g., fungal infections). Report any new symptoms to your doctor.

Following these precautions can help ensure the safe and effective use of cefotetan. Always consult your healthcare provider for advice tailored to your specific situation.

What special dietary instructions should I follow?

• Alcohol: Avoid alcohol during treatment and for at least 72 hours after completing the course.
• Food: No specific dietary restrictions are generally required with Cefotan. However, it’s always a good idea to maintain a balanced diet and stay hydrated.

What should I do if I forget a dose?

• Missed Dose: If you miss a dose, take it as soon as you remember. However, if it’s almost time for your next dose, skip the missed dose and do not double up to make up for a missed dose.
• Consult Your Healthcare Provider: If you’re unsure about what to do, or if you miss multiple doses, consult your healthcare provider for guidance on how to proceed.

What side effects can this medication cause?

Cefotan (cefotetan) can cause a range of side effects. While not everyone experiences side effects, here are some that may occur:

Common Side Effects:

• Gastrointestinal Issues: Nausea, vomiting, diarrhea, or abdominal pain.
• Injection Site Reactions: Pain, redness, or swelling at the injection site.
• Skin Rash: Mild rash or itching.

Less Common but Serious Side Effects:

• Allergic Reactions: Rash, itching, swelling, severe dizziness, or trouble breathing. Seek immediate medical attention if you experience these symptoms.
• Severe Diarrhea: Persistent diarrhea, which may be a sign of Clostridium difficile-associated diarrhea, can occur. It is important to inform your doctor if you experience severe, persistent diarrhea.
• Kidney Issues: Symptoms such as changes in urine output, swelling in the legs or ankles, or dark-colored urine could indicate kidney problems.
• Blood Issues: Unusual bleeding or bruising, pale skin, or symptoms of anemia (fatigue, weakness).

Rare Side Effects:

• Liver Issues: Jaundice (yellowing of the skin or eyes), dark urine, or upper abdominal pain.
• Seizures: Rare, but can occur, especially in those with severe kidney impairment or in cases of overdose.

If you experience any of these side effects or have concerns about any symptoms you’re experiencing, contact your healthcare provider for advice and further evaluation.

What should I know about storage and disposal of this medication?

Storage and Disposal of Cefotan:

Storage:

• Preparation and Reconstitution: Cefotan should be stored according to the instructions provided by your healthcare provider or pharmacist. It is usually reconstituted and diluted before administration.
• Temperature: Cefotan should be stored at room temperature, away from light and moisture. Do not freeze.

Disposal:

• Unused Medication: Dispose of any unused or expired Cefotan properly. Do not flush it down the toilet or pour it into a drain unless instructed to do so.
• Drug Take-Back Programs: Use a drug take-back program or follow local regulations for proper disposal. Many pharmacies have programs for disposing of unused medications.

In case of emergency/overdose

Emergency Symptoms:

• Severe Allergic Reactions: Difficulty breathing, swelling of the face, lips, tongue, or throat.
• Severe Diarrhea: Persistent, severe diarrhea which could indicate a more serious condition like Clostridium difficile infection.

Overdose:

• Symptoms: Signs of an overdose may include severe nausea, vomiting, diarrhea, or other unusual symptoms.
• Action: If you suspect an overdose, contact emergency medical services or go to the nearest emergency room immediately. Provide them with information about the medication and dosage.

What other information should I know?

• Monitoring: Your healthcare provider may need to monitor your kidney function, blood counts, and other health parameters while you are on Cefotan.
• Drug Interactions: Inform your healthcare provider about all other medications you are taking, including over-the-counter drugs and supplements, as Cefotan may interact with other drugs.
• Complete Course: Finish the full course of Cefotan as prescribed, even if you start feeling better before completing it. Stopping early may lead to the infection returning or developing antibiotic resistance.

Always follow your healthcare provider’s instructions and consult them if you have any concerns or questions about Cefotan.