WARNING

Cambia is a brand name for the drug diclofenac potassium, which belongs to a class of medications known as nonsteroidal anti-inflammatory drugs (NSAIDs). Like all medications, Cambia carries some risks and potential side effects:

• Gastrointestinal Effects: NSAIDs, including Cambia, can cause stomach upset, indigestion, ulcers, and gastrointestinal bleeding. These risks are higher in people who are older, have a history of ulcers, or take higher doses.
• Cardiovascular Risks: Long-term use of NSAIDs may increase the risk of heart attack or stroke, especially in people with pre-existing cardiovascular conditions.
• Kidney Effects: NSAIDs can affect kidney function, potentially leading to fluid retention, high blood pressure, or kidney damage, especially in people with underlying kidney disease.
• Allergic Reactions: Some individuals may experience allergic reactions to diclofenac, ranging from mild rash to severe reactions such as anaphylaxis.
• Liver Damage: In rare cases, NSAIDs like diclofenac can cause liver problems, including liver inflammation or liver failure.
• Drug Interactions: Cambia may interact with other medications, such as blood thinners, certain antidepressants, and some high blood pressure medications, potentially leading to serious complications.
• Other Side Effects: Common side effects of Cambia include headache, dizziness, nausea, and abdominal pain.

It’s important to use Cambia exactly as prescribed by your doctor and to discuss any concerns or existing health conditions with them before starting treatment. Always follow the recommended dosage and duration of use to minimize the risks associated with this medication.

Why is this medication prescribed?

Cambia, which contains diclofenac potassium, is typically prescribed for the short-term relief of acute pain and migraine headaches. Here are the main reasons why Cambia is prescribed:

• Migraine Headaches: Cambia is specifically approved for the treatment of migraine headaches in adults. It is used to relieve the pain and associated symptoms of migraines, such as nausea and sensitivity to light and sound.
• Pain Relief: Cambia is also used to treat acute pain conditions, such as dental pain, menstrual cramps, and musculoskeletal pain (e.g., back pain, arthritis).

Cambia works by inhibiting the production of certain chemicals in the body that cause inflammation and pain, known as prostaglandins. This helps reduce pain and inflammation associated with various conditions.

How should this medicine be used?

How Cambia Should Be Used:

• Dosage: The typical dosage of Cambia for migraine relief is one packet (50 mg) mixed with 1 to 2 ounces (30 to 60 mL) of water. This should be taken as soon as migraine symptoms appear.
• Administration: After mixing, Cambia should be consumed immediately. It can be taken with or without food.
• Frequency: Cambia should not be used more frequently than every 12 hours. For most patients, a single dose is sufficient per migraine attack. If the migraine persists or recurs, medical advice should be sought.
• Duration: Cambia is intended for short-term use to relieve acute symptoms. It should not be used for chronic conditions without medical supervision.
• Precautions: It’s important to follow the dosage instructions provided by your healthcare provider. Overuse or misuse of Cambia can lead to serious health risks, such as gastrointestinal bleeding, cardiovascular problems, and kidney damage.
• Monitoring: Regular monitoring by your healthcare provider is recommended while using Cambia, especially if you have pre-existing conditions such as heart disease, kidney problems, or gastrointestinal issues.

Always consult your doctor for specific instructions tailored to your condition and health status. They can provide guidance on the appropriate use of Cambia and monitor for any potential side effects or interactions with other medications you may be taking.

Other uses for this medicine

Some additional uses include:

• Postoperative Pain: Cambia may be used to manage pain following surgical procedures, particularly when short-term relief of inflammation and pain is needed.
• Gout: It can sometimes be used to manage pain and inflammation associated with gout attacks, although other medications are often preferred.
• Fever: In some cases, Cambia may be used to reduce fever, particularly when other medications are not suitable or available.

What special precautions should I follow?

When using Cambia, it’s crucial to follow these special precautions to minimize risks and ensure safe use:

• Medical History: Inform your healthcare provider about any medical conditions you have, especially if you have a history of heart disease, high blood pressure, liver or kidney disease, gastrointestinal disorders (such as ulcers), asthma, or bleeding disorders.
• Allergies: Tell your doctor about any allergies you have to medications, especially if you have had allergic reactions to NSAIDs (such as ibuprofen, aspirin) in the past.
• Drug Interactions: Cambia can interact with other medications, including blood thinners (e.g., warfarin), corticosteroids, certain antidepressants, and other NSAIDs. Make sure your doctor is aware of all medications you are taking, including over-the-counter drugs and supplements.
• Pregnancy and Breastfeeding: Cambia should be used with caution during pregnancy, especially in the third trimester, as it may harm the unborn baby or interfere with labor. It should generally be avoided in the first and second trimesters unless deemed necessary by a healthcare provider. It is also not recommended during breastfeeding, as small amounts of diclofenac can pass into breast milk.
• Age Considerations: Older adults may be more sensitive to the side effects of Cambia, especially gastrointestinal bleeding and kidney problems. Dosing adjustments may be necessary.
• Gastrointestinal Risks: Cambia, like other NSAIDs, can increase the risk of gastrointestinal ulcers, bleeding, and perforation, which can be serious and potentially life-threatening. To reduce this risk, your doctor may prescribe the lowest effective dose for the shortest duration necessary.
• Kidney and Liver Function: Regular monitoring of kidney and liver function may be required during treatment with Cambia, especially if you have pre-existing kidney or liver conditions.
• Heart Health: NSAIDs like Cambia may increase the risk of cardiovascular events such as heart attack or stroke, particularly with long-term use or in individuals with existing heart disease. It’s essential to discuss these risks with your doctor, especially if you have heart disease or risk factors for heart disease.

Always follow your healthcare provider’s instructions carefully when using Cambia, and do not hesitate to ask questions or seek clarification about its use, potential side effects, and precautions.

What special dietary instructions should I follow?

There are no specific dietary restrictions associated with Cambia. However, to minimize the risk of stomach upset and gastrointestinal side effects:

• Take with Food: Cambia should be taken with food or milk to help reduce stomach irritation.
• Avoid Alcohol: Alcohol can increase the risk of stomach bleeding when taken with NSAIDs. It’s advisable to avoid alcohol while using Cambia.

What should I do if I forget a dose?

If you miss a dose of Cambia, take it as soon as you remember, unless it is almost time for your next scheduled dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

What side effects can this medication cause?

Cambia (diclofenac potassium), like all medications, can cause side effects. Some of the common and less common side effects include:

• Gastrointestinal Effects: These are among the most common side effects and can include stomach pain, indigestion, heartburn, nausea, vomiting, diarrhea, and stomach ulcers. NSAIDs like Cambia can increase the risk of gastrointestinal bleeding and perforation, which can be serious and potentially life-threatening.
• Cardiovascular Effects: NSAIDs, including Cambia, may increase the risk of heart attack, stroke, or other cardiovascular events, especially with long-term use or in individuals with pre-existing heart conditions.
• Kidney Effects: NSAIDs can affect kidney function, leading to fluid retention, high blood pressure, and worsening of pre-existing kidney problems or even kidney failure.
• Liver Effects: In rare cases, NSAIDs like Cambia can cause liver inflammation or liver damage.
• Allergic Reactions: Some individuals may experience allergic reactions to diclofenac, ranging from mild rash and itching to severe reactions such as difficulty breathing, swelling of the face/throat, and anaphylaxis (a severe allergic reaction that requires immediate medical attention).
• Central Nervous System Effects: Cambia can cause headaches, dizziness, drowsiness, and in some cases, confusion.
• Skin Reactions: Skin reactions such as rash, itching, and sensitivity to sunlight (photosensitivity) may occur.
• Blood Disorders: Cambia can rarely cause blood disorders such as anemia, decreased platelet count (thrombocytopenia), and decreased white blood cell count (leukopenia).
• Vision Changes: Blurred vision or other visual disturbances may occur in some individuals.
• Fluid Retention: NSAIDs like Cambia can cause fluid retention, leading to swelling in the legs, ankles, or feet.

It’s important to note that not everyone using Cambia will experience these side effects, and some individuals may experience different or additional side effects. If you experience any unusual symptoms or side effects while taking Cambia, especially severe symptoms like chest pain, difficulty breathing, or signs of gastrointestinal bleeding (such as black, tarry stools), seek immediate medical attention.

Discuss any concerns about side effects with your healthcare provider before starting Cambia, and follow their instructions closely to minimize risks and ensure safe use of the medication.

What should I know about storage and disposal of this medication?

Storage and Disposal of Cambia:

• Storage: Store Cambia packets at room temperature, away from moisture and heat. Keep them in their original packaging until ready to use. Avoid storing Cambia in the bathroom or in places where it might get damp or humid.
• Disposal: Dispose of Cambia packets properly by following any specific disposal instructions provided by your healthcare provider or local pharmacy. If no specific instructions are given, you can dispose of unused or expired Cambia by:
  • Mixing the contents of the packet with an undesirable substance (e.g., dirt, cat litter) in a sealed plastic bag.
  • Placing the sealed bag in your household trash.
  • Make sure to remove any personal information from the packaging before disposal.

In case of emergency/overdose

In case of an emergency or overdose of Cambia, seek immediate medical attention or contact a poison control center (1-800-222-1222 in the United States) for assistance. Overdose symptoms may include severe stomach pain, vomiting, shallow breathing, fainting, or coma.

What other information should I know?

• Regular Monitoring: Your healthcare provider may regularly monitor your kidney function, liver function, and overall health while you are taking Cambia, especially if you are using it for an extended period or have pre-existing health conditions.
• Avoid Alcohol: Limit alcohol consumption while taking Cambia, as it can increase the risk of stomach bleeding and other gastrointestinal side effects.
• Sun Exposure: Cambia may make you more sensitive to sunlight. Avoid prolonged sun exposure, wear protective clothing, and use sunscreen when outdoors.
• Interactions: Inform your healthcare provider about all medications, supplements, and herbal products you are taking, as Cambia can interact with other medications, potentially affecting their effectiveness or increasing the risk of side effects.
• Medical Alert: Carry a medical alert card or wear a medical alert bracelet to inform healthcare providers that you are taking Cambia, especially if you have any allergies or medical conditions.
• Patient Education: Understand the signs and symptoms of potential side effects or complications associated with Cambia, and contact your healthcare provider if you experience any concerns or adverse reactions.

By following these guidelines and staying informed about the proper use, storage, and disposal of Cambia, you can help ensure safe and effective treatment under the guidance of your healthcare provider.