Why is this medication prescribed?

C1-Esterase Inhibitor Human Injection is prescribed for the treatment of hereditary angioedema (HAE). Hereditary angioedema is a genetic disorder that causes episodes of swelling in various parts of the body, including the hands, feet, face, abdomen, and throat. This condition is caused by a deficiency or malfunction of C1-esterase inhibitor, which normally helps regulate the complex system of proteins involved in inflammation and immune response.

How should this medicine be used?

How C1-Esterase Inhibitor Human Injection should be used:

• Dosage: The dosage of C1-Esterase Inhibitor Human Injection is typically based on body weight and the severity of the angioedema attack. It is administered intravenously (into the vein).
• Administration: Healthcare providers usually administer the injection in a clinical setting, such as a hospital or infusion center. It is important to follow the specific instructions provided by the healthcare provider.
• Monitoring: After administration, patients are often monitored for a period of time to watch for any adverse reactions and to ensure the treatment is effective.
• Frequency: The frequency of administration can vary depending on the individual’s response and the recurrence of angioedema attacks. Some patients may require regular infusions for long-term management.
• Storage: The injection should be stored according to the manufacturer’s instructions, usually at controlled room temperature.
• Follow-up: Patients may need regular follow-up appointments with their healthcare provider to assess the effectiveness of the treatment and adjust the dosage if necessary.

It’s crucial for patients to communicate with their healthcare provider regarding any concerns or side effects experienced during treatment with C1-Esterase Inhibitor Human Injection. This medication is specifically designed to manage acute attacks and, in some cases, for prophylactic (preventive) use to reduce the frequency and severity of attacks in patients with hereditary angioedema.

Other uses for this medicine

In some cases, healthcare providers may consider using C1-Esterase Inhibitor Human Injection off-label for conditions or situations not specifically approved by regulatory authorities. This might include severe allergic reactions (anaphylaxis) that are resistant to standard treatment, although the evidence for this use is limited.

What special precautions should I follow?

When using C1-Esterase Inhibitor Human Injection, it is important to follow certain precautions to ensure safe and effective treatment:

• Allergies: Inform your healthcare provider if you have any allergies to medications, particularly to human plasma-derived products or any components of C1-Esterase Inhibitor Human Injection.
• Infections: Due to the nature of the product being derived from human plasma, there is a risk of transmitting infectious agents, such as viruses and theoretically, the Creutzfeldt-Jakob disease (CJD) agent. The manufacturing process includes steps to reduce this risk, but caution should still be exercised.
• Pregnancy and Breastfeeding: The safety of C1-Esterase Inhibitor Human Injection during pregnancy or breastfeeding has not been well established. It should only be used if clearly needed and the potential benefits outweigh the risks.
• Monitoring: During treatment, your healthcare provider may monitor you for any signs of allergic reactions, infections, or other adverse effects. They may also monitor your response to the treatment to adjust the dosage or frequency of administration as needed.
• Storage and Handling: Follow the specific storage instructions provided by the manufacturer. C1-Esterase Inhibitor Human Injection should be stored properly to maintain its effectiveness and safety.
• Medical History: Provide a detailed medical history to your healthcare provider, including any past reactions to medications or previous episodes of angioedema, to help guide treatment decisions.

Always adhere to the advice and instructions given by your healthcare provider regarding the use of C1-Esterase Inhibitor Human Injection. This will help maximize the benefits of treatment while minimizing potential risks.

What special dietary instructions should I follow?

There are typically no specific dietary restrictions associated with C1-Esterase Inhibitor Human Injection. However, it’s always advisable to maintain a balanced diet and follow any dietary recommendations provided by your healthcare provider to support overall health and well-being.

What should I do if I forget a dose?

If you miss a dose of C1-Esterase Inhibitor Human Injection, contact your healthcare provider or infusion center promptly. They will advise you on what to do based on your specific treatment plan. It’s important not to double the dose to make up for a missed one unless instructed to do so by your healthcare provider.

What side effects can this medication cause?

C1-Esterase Inhibitor Human Injection is generally well-tolerated, but like any medication, it can cause side effects in some people. Common side effects may include:

• Headache: Mild to moderate headaches are a commonly reported side effect.
• Nausea: Some individuals may experience nausea or gastrointestinal discomfort.
• Fever: Low-grade fever can occur in some patients.
• Injection Site Reactions: Redness, swelling, or irritation at the injection site may occur.
• Dizziness: Feeling dizzy or lightheaded can occasionally happen.
• Fatigue: Some patients may feel tired or experience fatigue.
• Allergic Reactions: Although rare, allergic reactions to C1-Esterase Inhibitor Human Injection can occur. Symptoms may include rash, itching, swelling (especially of the face/tongue/throat), severe dizziness, or trouble breathing.

It’s important to note that severe allergic reactions (anaphylaxis) are possible but rare. If you experience any serious side effects, especially signs of allergic reaction, seek immediate medical attention.

These lists are not exhaustive, and other side effects may occur. If you notice any unusual symptoms while receiving C1-Esterase Inhibitor Human Injection, promptly inform your healthcare provider. They can help assess whether the symptoms are related to the medication and provide appropriate guidance.

What should I know about storage and disposal of this medication?

Storage of C1-Esterase Inhibitor Human Injection:

• Temperature: Store C1-Esterase Inhibitor Human Injection according to the manufacturer’s recommendations. Typically, it should be stored at controlled room temperature. Avoid freezing or exposing it to extreme temperatures.
• Handling: Follow proper handling procedures to maintain sterility and prevent contamination. Only healthcare professionals trained in the administration of intravenous medications should handle and administer C1-Esterase Inhibitor Human Injection.
• Expiration Date: Check the expiration date on the packaging. Do not use C1-Esterase Inhibitor Human Injection if it has expired.
• Storage Conditions: Keep the medication in its original packaging until ready for use to protect it from light and moisture.

Disposal of C1-Esterase Inhibitor Human Injection:

• Unused Medication: Unused portions of C1-Esterase Inhibitor Human Injection should be disposed of properly according to local regulations or as instructed by your healthcare provider or pharmacist.
• Needles and Syringes: Dispose of needles, syringes, and any other materials used for administration in a puncture-proof container. Follow local guidelines for disposal of medical waste.

In case of emergency/overdose

In case of emergency or overdose with C1-Esterase Inhibitor Human Injection:

• Seek Immediate Medical Attention: If you suspect an overdose or experience severe adverse reactions after receiving C1-Esterase Inhibitor Human Injection, seek emergency medical help immediately. Call your local emergency services or go to the nearest emergency room.
• Symptoms of Overdose: Symptoms of an overdose may include severe allergic reactions (anaphylaxis), which can manifest as difficulty breathing, swelling of the face or throat, hives, rapid heartbeat, or severe dizziness.

What other information should I know?

• Regular Monitoring: Your healthcare provider may schedule regular appointments to monitor your response to C1-Esterase Inhibitor Human Injection and adjust your treatment plan as needed.
• Adverse Reactions: Be aware of potential side effects or adverse reactions associated with C1-Esterase Inhibitor Human Injection. Common side effects may include headache, nausea, fever, or injection site reactions. Report any unusual symptoms to your healthcare provider promptly.
• Medical ID: Consider wearing a medical identification bracelet or necklace that indicates you are receiving C1-Esterase Inhibitor Human Injection. This can be helpful in case of emergencies or if you are unable to communicate your medical history.
• Follow-Up Care: Follow all instructions provided by your healthcare provider regarding the use of C1-Esterase Inhibitor Human Injection, including any dietary restrictions or lifestyle modifications that may be recommended.

Always keep contact information for your healthcare provider and emergency services readily available in case of any unexpected situations related to your treatment with C1-Esterase Inhibitor Human Injection. This ensures you can quickly access help if needed and receive appropriate medical care.