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Busulfan Injection

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WARNING

The amount of blood cells in your bone marrow may drastically drop as a result of receiving a busulfan injection. All of the medications you are taking should be disclosed to your doctor and pharmacist. Busulfan’s adverse effects can be more severe if you take it along with other drugs that can lower blood counts. Call your doctor right away if you have any of the following symptoms: Unusual bleeding or bruises; fever, sore throat, persistent cough, and congestion, among other infection-related symptoms.

Keep all of your appointments with your physician and the lab. Before, during, and after your treatment, your doctor will conduct laboratory tests to monitor your body’s response to the medicine busulfan and determine whether it has an impact on your blood cells.

Busulfan may make you more likely to get other malignancies. Describe the dangers of receiving busulfan to your doctor.

Why is this medication prescribed?

Injections of busulfan are used in conjunction with other medications to treat a specific type of chronic myelogenous leukaemia (CML; a cancer of the white blood cells) and to eliminate cancerous cells in the bone marrow in order to prepare for a bone marrow transplant. Alkylating agents are a class of drugs that includes busulfan. It functions by reducing or halting the development of cancer cells within your body.

How should this medicine be used?

Busulfan is administered intravenously (into a vein) over a period of two hours by a doctor or nurse in a medical setting. Prior to a bone marrow transplant, it is typically administered every 6 hours for 4 days (for a total of 16 doses).

When taking the medicine, busulfan injectable therapy may result in seizures. In order to assist you avoid seizures both before and after your busulfan injection therapy, your doctor will prescribe another drug.

Other uses for this medicine

In order to prepare the bone marrow and cancer cells for a bone marrow transplant in patients with various forms of cancer, busulfan injection is also used in combination with other medications.

Ask your doctor or pharmacist for more details if you believe this drug should be used for something else.

What special precautions should I follow?

Before receiving busulfan injection,

  • If you have an allergy to busulfan, any other drugs, or any of the components in busulfan injection, let your doctor and pharmacist know right away. Request a list of the components from your pharmacist.
  • If you have an allergy to busulfan, any other drugs, or any of the components in busulfan injection, let your doctor and pharmacist know right away. Request a list of the components from your pharmacist.
    Inform your doctor and pharmacist about all prescription and over-the-counter drugs, vitamins, dietary supplements, and herbal products that you are now taking or intend to use. Acetaminophen (Tylenol), clozapine (Clozaril, FazaClo), cyclosporine (Sandimmune, Gengraf, Neoral), itraconazole (Sporanox), drugs for mental illness and nausea, or meperidine should all be mentioned (Demerol). Your physician might need to adjust the dosage of your drugs or keep a close eye on you for side effects. Tell your doctor about all of the medications you are taking, even those that don’t seem to interact with busulfan since there are a lot of other drugs that could.
  • Inform your doctor if you have ever experienced seizures, head trauma, or radiation therapy or other chemotherapy in the past.
  • You should be aware that busulfan may affect a woman’s regular menstrual cycle, stop a man’s ability to reproduce, and result in infertility (difficulty becoming pregnant). However, you shouldn’t presumptively believe that neither you nor your partner could conceive. Inform your doctor if you are expecting, intend to get pregnant, or are nursing a baby. While undergoing chemotherapy or for a while after treatments, you shouldn’t intend to get pregnant. (Ask your doctor for more information.) To prevent conception, use a proven birth control method. If you conceive while taking busulfan, contact your doctor right away. The foetus could suffer from busulfan.

What side effects can this medication cause?

Busulfan might have negative effects. If any of these symptoms are severe or do not go away, let your doctor know right once:

  • Nausea
  • Diarrhea
  • Reduced appetite
  • Loss of weight
  • Constipation
  • Mouth and throat sores
  • Mouth ache
  • Headache
  • Having trouble falling or staying asleep
  • Feeling unusually worried or anxious
  • Dizziness
  • Face, arm, hand, foot, ankle, or lower leg swelling
  • Chest discomfort
  • Back, joint, or muscle pain
  • Rash
  • Dry skin and itching
  • Skin coloration
  • Hair fall

Some adverse effects can be very harmful. Call your doctor right away if you have any of these signs or any of those in the IMPORTANT WARNING section:

  • Tarry, black stools
  • Red faeces
  • Vomiting
  • Abdominal pain
  • Unusual weakness or fatigue
  • Having trouble breathing
  • Seizures

Other negative effects of busulfan are possible. If you have any strange side effects while taking this medicine, call your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

What should I know about storage and disposal of this medication?

The hospital or medical facility where you receive each dose of this drug will have it on hand for storage.

In case of emergency/overdose

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Additionally, information can be found online at https://www.poisonhelp.org/help. Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

Overdose signs could include the following:

  • Tarry, black stools
  • Red faeces
  • Abnormal bleeding or bruising
  • Unusual weakness or fatigue

What other information should I know?

Keep all of your doctor’s appointments.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Busulfex® Injection
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