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Briviact (Generic Brivaracetam Injection)

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Why is this medication prescribed?

Brivaracetam injection is used to treat partial onset seizures (seizures affecting only a portion of the brain) in adults, children, and infants aged one month or older who are unable to take oral medication. Anticonvulsants are a class of drugs that includes brivaracetam. It functions by reducing the brain’s aberrant electrical activity.

How should this medicine be used?

As a solution (liquid), brivaracetam injection is administered intravenously (into a vein) over a period of 2 to 15 minutes. As long as you are unable to swallow brivaracetam pills or oral solution, it is typically administered twice daily.

You can use brivaracetam injection at home or have it as an injection in a hospital. Your doctor will instruct you on how to administer the brivaracetam injection if you will be doing so at home. Make sure you comprehend these instructions, and if you have any issues, consult your healthcare professional.

Depending on how well the drug works for you and the adverse effects you encounter, your doctor may raise or decrease your dose. Tell your doctor how you are feeling while receiving brivaracetam therapy.

Brivaracetam could cause addiction. Use the medication only as directed by your doctor, which means that you shouldn’t exceed the recommended dosage, frequency, or duration.

Your problem won’t be cured, but brivaracetam may help manage it. Even if you feel good, keep taking brivaracetam. Even if you encounter side effects including strange behavioural or emotional changes, never discontinue using brivaracetam injection without consulting your doctor first. The severity of your seizures could worsen if you abruptly stop using brivaracetam. Most likely, your dosage will be gradually reduced by your doctor.

Other uses for this medicine

Ask your doctor or pharmacist for more details if you think this drug may be recommended for other conditions.

What special precautions should I follow?

Before taking brivaracetam injection,

  • If you have an allergy to brivaracetam, any other medications, or any of the ingredients in brivaracetam injection, let your doctor and pharmacist know right away. For a list of the ingredients, consult the Medication Guide or speak with your pharmacist.
  • Inform your doctor and pharmacist about all prescription and over-the-counter drugs, vitamins, dietary supplements, and herbal products that you are now taking or intend to use. Include any of the following: levetiracetam (Elepsia, Keppra, Spritam), phenytoin (Dilantin, Phenytek), and rifampin (Carbatrol, Epitol, Equetro, Tegretol, Teril) (Rifadin, Rimactane). Your physician might need to adjust the dosage of your drugs or keep a close eye on you for side effects.
  • Inform your doctor if you consume excessive amounts of alcohol, use illegal substances, or abuse prescription pharmaceuticals. Tell your doctor if you have or have ever had liver illness, kidney disease, depression, mood disorders, suicidal thoughts or actions, or liver disease. Dialysis is a procedure used to clean the blood outside the body when the kidneys are not functioning properly.
  • Inform your physician if you are nursing a baby, intend to get pregnant, or are already pregnant. Call your doctor if you become pregnant while taking brivaracetam.
  • You should be aware that brivaracetam may cause drowsiness or euphoria, as well as impaired vision, balance issues, or dizziness. Until you are certain of how this drug affects you, avoid operating machinery, driving a car, or engaging in other tasks that call for attentiveness or coordination.
  • Inquire with your doctor if drinking alcohol is safe for you to do while taking brivaracetam. Brivaracetam can exacerbate the negative effects of alcohol.
  • You should be aware that using brivaracetam injection may cause unexpected changes in your mental health and increase your risk of being suicidal (thinking about harming or killing yourself, preparing to do so, or trying to do so). In clinical investigations, roughly 1 in 500 adults and children aged 5 and older who were prescribed anticonvulsants like brivaracetam injection for a range of disorders developed suicidal thoughts while receiving treatment. One week after they began taking the medicine, several of these folks started exhibiting suicidal thoughts and actions. If you use an anticonvulsant drug like brivaracetam injection, there is a chance that your mental state may change, but there is also a chance that your condition will not be addressed and that your mental state will change. Whether the hazards of using an anticonvulsant drug outweigh the dangers of not using it will be decided by you and your doctor. Any of the following symptoms should prompt you, your family, or your carer to call your doctor immediately away: panic attacks, agitation or restlessness, fresh occurrences of, or worsening of, irritability, anxiety, or depression, acting on risky impulses, sleep difficulties, aggressive, angry, or violent behaviour, mania (frenzied, abnormally excited mood), talking or thinking about wanting to harm yourself or end your life, or any other unusual changes in behaviour or mood. Make sure your family or carer is aware of any symptoms that could be significant so they can contact the doctor on your behalf if you are unable to call for help.

What special dietary instructions should I follow?

Keep eating normally unless your doctor instructs you otherwise.

What should I do if I forget a dose?

The missed dose should be taken as soon as you remember. If the next dose is soon due, skip the missed one and carry on with your regular dosing plan. To make up for a missing dose, do not take a second one.

What side effects can this medication cause?

Side effects from brivaracetam injection are possible. If any of these symptoms are severe or do not go away, let your doctor know right once:

  • Constipation
  • Nausea
  • Vomiting
  • Alterations in food taste
  • Severe fatigue or lack of vigour
  • Feeling sluggish
  • Discomfort near the injection site for brivaracetam

Some adverse effects can be very harmful. Brivaracetam injection should be stopped immediately if you suffer any of the following symptoms or any of those noted in the SPECIAL PRECAUTIONS section:

  • Face, throat, tongue, lips, and eye swelling
  • Breathing or swallowing challenges
  • Hoarseness
  • Hallucinations (seeing things or hearing voices that do not exist)
  • Delusions (having weird ideas or convictions that are unfounded in reality), such as the conviction that someone is attempting to harm you when they are not

Other negative effects from brivaracetam injection are possible. If you experience any strange issues while taking this medicine, contact your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

In case of emergency/overdose

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Additionally, information can be found online at https://www.poisonhelp.org/help. Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

Symptoms of overdose may include the following:

  • Sleepiness
  • Extreme fatigue
  • Dizziness
  • Difficulty maintaining balance
  • Double or blurry vision
  • Reduced heart rate
  • Nausea
  • Feeling uneasy

What other information should I know?

Do not share your medication with anybody else. The drug brivaracetam is under control. Only a limited amount of refills are permitted for prescriptions; if you have any doubts, speak with your pharmacist.

Keep all of your doctor’s appointments.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Briviact®
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