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Brigatinib

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Why is this medication prescribed?

A specific kind of non-small cell lung cancer (NSCLC) that has spread to other body sections is treated with brugatinib. Kinase inhibitors are a class of drugs that includes brigatinib. It functions by preventing the action of a problematic protein that instructs cancer cells to proliferate. This aids in containing or halting the spread of cancer cells.

How should this medicine be used?

Brigatinib is available as an oral tablet. It is typically taken once day, with or without food. Take brigatinib every day at roughly the same time. Ask your doctor or pharmacist to explain any instructions on your prescription label that you are unsure about following. Consume brigatinib as prescribed. Never take it in larger or less amounts or more frequently than directed by your doctor.

Do not chew or crush the tablets; instead, swallow them whole.

Do not take another dose of brigatinib if you vomit after taking it. Continue taking your medication as usual.

After seven days of treatment, your doctor may increase your brigatinib dosage once from the low starting dose.

Depending on the side effects you experience throughout your treatment, your doctor may decide to temporarily or permanently cease your brigatinib or other medications, or reduce the dose you are already taking. Discuss your feelings regarding your treatment with your doctor. Without first seeing your doctor, do not discontinue taking brigatinib.

For a copy of the manufacturer’s information for the patient, ask your pharmacist or doctor.

Other uses for this medicine

Ask your doctor or pharmacist for more details if you believe this drug should be used for something else.

What special precautions should I follow?

Before taking brigatinib,

  • If you have an allergy to brigatinib, any other drugs, or any of the ingredients in brigatinib tablets, let your doctor and pharmacist know right once. Request a list of the components from your pharmacist.
  • Inform your doctor and pharmacist about any additional prescription and over-the-counter medications, vitamins, herbal items, nutritional supplements, and any drugs you are now taking or intend to take. Any of the following should be mentioned: Antifungal medications like naloxone, buprenorphine, itraconazole (Onmel, Sporanox, Tolsura), and ketoconazole (Suboxone), phenobarbital, efavirenz (Sustiva, in Atripla, Symfi), nefazodone, nelfinavir (Viracept), nevirapine (Viramune), clarithromycin, cyclosporine (Gengraf, Neoral, Sandimmune), diltiazem (Cardizem, Cartia, Diltzac, others), and erythromycin (E.E.S., Eryc, Erythrocin), ritonavir (Norvir, in Kaletra, Technivie, Viekira), phenytoin (Dilantin, Phenytek), pioglitazone (Actos, in Actoplus Met, Duetact, Oseni), rifampin (Rifadin, Rimactane, in Rifamate, in Rifater), tacrolimus (Astagraf, Envarsus, Prograf), sirol (Calan, Verelan, in Tarka). Your physician might need to adjust the dosage of your drugs or keep a close eye on you for side effects. Tell your doctor about all of the drugs you are taking, even any not on this list, as many other drugs may also interact with brigatinib.
  • Please let your doctor know if you are taking any herbal supplements, especially St. John’s wort.
  • Inform your doctor if you currently have or previously had renal or liver illness, high blood pressure, a sluggish heartbeat, diabetes, or any other blood sugar issues.
  • If you are pregnant, intend to become pregnant, or intend to father a child, let your doctor know right away. You should not use hormonal contraceptives (birth control pills, patches, rings, implants, or injections) as your sole method of birth control while receiving therapy with brupatinib since they may interfere with their effectiveness. You must use a barrier technique or another non-hormonal birth control (device that blocks sperm from entering the uterus such as a condom or a diaphragm). Ask your doctor to assist you in selecting a birth control technique that will be effective for you. You must take non-hormonal birth control while receiving treatment and for four months following your last dose if you are a female. If you’re a man, you and your female companion should both use birth control while you’re receiving therapy and for three months following your last pill. The foetus could suffer from brugatinib.
  • Describe to your doctor if you are nursing a baby. During your brigatinib treatment and for up to a week following your last dosage, you shouldn’t breastfeed.
  • You should be aware that this drug may reduce male fertility. You should discuss the dangers of taking brigatinib with your doctor.

What special dietary instructions should I follow?

While taking brigatinib, avoid consuming grapefruit and grapefruit juice.

What should I do if I forget a dose?

Ignore the missed dose and carry on with my normal dosing routine. To make up for a missing dose, do not take a second one.

Consult your doctor before starting brigatinib again if you miss 14 or more days without taking it. Most likely, you’ll need to start taking it again at a lesser dosage.

What side effects can this medication cause?

Brigatinib might have negative effects. If any of these symptoms are severe or do not go away, let your doctor know right once:

  • Nausea
  • Diarrhea
  • Vomiting
  • Constipation
  • Tiredness
  • Rash
  • Headache
  • Tingling, numbness, discomfort, or burning in the hands or feet
  • Joint or back ache
  • Reduced appetite
  • Having trouble falling or staying asleep

Some adverse effects can be very harmful. Call your doctor right away if you encounter any of these symptoms, or seek emergency care:

  • Respiratory issues or lack of breath
  • Chest ache
  • Whether or not you cough up mucus
  • Fever
  • Headache, lightheadedness, dizziness, or faintness
  • Double or blurry vision
  • Observing light-flashes
  • Light causing eye discomfort
  • Observing “floaters” or tiny dots
  • Excessive hunger, intense thirst, frequent urination, hazy vision, or weakness
  • Weight loss, nausea, or upper stomach pain that can travel to the back or get worse after eating
  • Sluggish or unpredictable heartbeat
  • Weakness, discomfort, or muscular spasms

Other negative effects of brigatinib are possible. If you experience any strange issues while taking this medicine, contact your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

What should I know about storage and disposal of this medication?

Keep this medication tightly closed in the original container and out of the reach of children. Store it away from excessive heat and moisture at room temperature (not in the bathroom).

As many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for young children to open, it is crucial to keep all medications out of sight and out of reach of children. Always lock safety caps and promptly stash medication up and away from young children where it is out of their sight and reach to prevent poisoning. http://www.upandaway.org

Unused prescriptions must be disposed of carefully to prevent pets, kids, and other people from ingesting them. You should not, however, dispose of this medication in the toilet. Instead, utilising a medicine take-back programme is the easiest approach to get rid of your medication. To find out about take-back programmes in your area, speak with your pharmacist or the garbage/recycling department in your city. If you do not have access to a take-back programme, see the FDA’s Safe Disposal of Medicines website at http://goo.gl/c4Rm4p for additional information.

In case of emergency/overdose

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Additionally, information can be found online at https://www.poisonhelp.org/help. Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

What other information should I know?

Keep all of your appointments with your physician and the lab. Before you start your therapy, your doctor will run a lab test to determine whether brigatinib can treat your cancer. In order to monitor your body’s reaction to brigatinib, your doctor will also request specific lab tests and take your blood pressure both before and throughout therapy.

No one else should take your medication. Any queries you may have regarding medication refills should be directed to your pharmacist.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Alunbrig®
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