Why is this medication prescribed?

Braftovi (generic name: encorafenib) is a medication primarily prescribed for the treatment of a specific type of skin cancer called melanoma. It’s specifically used for melanoma that has a certain genetic mutation known as BRAF V600E or V600K mutation. Braftovi works by inhibiting the activity of the BRAF protein, which is involved in the abnormal cell growth seen in melanoma with these mutations. When used in combination with another medication called binimetinib, Braftovi has been shown to be effective in treating unresectable or metastatic melanoma. However, it’s crucial that patients consult their healthcare provider for accurate diagnosis and appropriate treatment recommendations.

How should this medicine be used?

Braftovi (encorafenib) is typically taken orally, as directed by a healthcare provider. Here’s a general guide on how it should be used:

• Dosage: The dosage of Braftovi can vary depending on factors like the type and stage of cancer being treated, the patient’s overall health, and other medications they may be taking. Always follow the dosage instructions provided by your healthcare provider.
• Timing: Braftovi is usually taken once daily, with or without food. It’s essential to take it at the same time each day to maintain consistent levels of the medication in your body.
• Swallowing: Swallow the capsule whole with a glass of water. Do not crush, chew, or break the capsule unless your healthcare provider advises otherwise.
• Missed Dose: If you miss a dose of Braftovi, take it as soon as you remember, unless it’s close to the time of your next dose. In that case, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
• Duration: Continue taking Braftovi for as long as your healthcare provider prescribes, even if you start feeling better. Stopping the medication prematurely could allow the cancer to return or worsen.
• Monitoring: Your healthcare provider may perform regular check-ups and tests to monitor your progress and assess the effectiveness of Braftovi. Follow-up appointments are crucial for adjusting your treatment plan as needed.
• Side Effects: Be aware of potential side effects of Braftovi and report any unusual symptoms to your healthcare provider promptly. Common side effects may include nausea, diarrhea, fatigue, headache, and skin rash.
• Interactions: Inform your healthcare provider about all medications, supplements, and herbal products you’re taking, as some may interact with Braftovi, affecting its effectiveness or increasing the risk of side effects.

Always consult your healthcare provider or pharmacist if you have any questions or concerns about how to use Braftovi properly. They can provide personalized guidance based on your specific medical situation.

Other uses for this medicine

While Braftovi (encorafenib) is primarily used to treat melanoma with specific genetic mutations, it may have potential uses in other cancers or conditions. However, it’s crucial to note that using medications off-label (for purposes other than those approved by regulatory agencies) should only be done under the guidance of a qualified healthcare provider. They can assess the risks and benefits based on your individual medical situation.

What special precautions should I follow?

Regarding special precautions for Braftovi, here are some key points to consider:

• Pregnancy and Breastfeeding: Braftovi may cause harm to a developing fetus, so it’s essential to avoid becoming pregnant while taking this medication. Effective contraception should be used during treatment and for a period afterward as recommended by your healthcare provider. It’s not known if Braftovi passes into breast milk, so breastfeeding while taking Braftovi is not recommended.
• Liver Function: Braftovi may affect liver function, so regular monitoring of liver enzymes through blood tests may be necessary during treatment. Inform your healthcare provider if you have a history of liver disease or if you experience symptoms such as jaundice (yellowing of the skin or eyes), dark urine, or persistent nausea and vomiting.
• Heart Health: Some patients may experience heart-related side effects while taking Braftovi, such as changes in heart rhythm (QT prolongation) or decreased heart function. Your healthcare provider may monitor your heart function with electrocardiograms (ECGs) and other tests, especially if you have a history of heart problems or are taking other medications that can affect heart rhythm.
• Muscle Pain and Weakness: Braftovi may cause muscle-related side effects such as pain, weakness, or inflammation (rhabdomyolysis). Inform your healthcare provider if you experience persistent muscle symptoms, as they may need to adjust your treatment or monitor you more closely.
• Allergic Reactions: Some individuals may experience allergic reactions to Braftovi, which can be serious. Seek immediate medical attention if you develop symptoms such as rash, itching, swelling (especially of the face, tongue, or throat), severe dizziness, or trouble breathing.
• Interactions: Braftovi can interact with other medications, supplements, or herbal products, potentially affecting its effectiveness or increasing the risk of side effects. Inform your healthcare provider about all the medications and supplements you’re taking before starting Braftovi.
• Special Populations: Certain populations, such as elderly individuals or those with impaired kidney function, may require dosage adjustments or closer monitoring while taking Braftovi. Discuss any special considerations with your healthcare provider.

Always follow your healthcare provider’s instructions and recommendations regarding the use of Braftovi and report any concerning symptoms promptly. They can provide personalized guidance based on your specific medical history and needs.

What special dietary instructions should I follow?

Regarding special dietary instructions for Braftovi, there are no specific dietary restrictions associated with this medication. However, it’s essential to maintain a balanced and nutritious diet to support overall health and well-being, especially during cancer treatment. If you have any concerns about diet or nutrition, consult with your healthcare provider or a registered dietitian for personalized guidance.

What should I do if I forget a dose?

If you forget a dose of Braftovi, take it as soon as you remember, unless it’s close to the time of your next dose. In that case, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one. If you’re unsure about what to do, consult your healthcare provider or pharmacist for guidance. Consistency in taking your medication is essential for optimal treatment outcomes, so try to establish a routine to help remember your doses.

What side effects can this medication cause?

Braftovi (encorafenib) can cause a range of side effects, although not everyone will experience them. Common side effects may include:

• Nausea and Vomiting: Feeling sick to your stomach or vomiting.
• Diarrhea: Changes in bowel habits, including loose stools or diarrhea.
• Fatigue: Feeling tired or lacking energy.
• Abdominal Pain: Discomfort or pain in the abdomen.
• Headache: Mild to moderate headaches may occur.
• Skin Rash: Some people may develop a rash or other skin reactions.
• Joint Pain: Pain or discomfort in the joints.
• Decreased Appetite: Loss of appetite or changes in eating habits.
• Fever: Some individuals may experience fever as a side effect.
• Elevated Liver Enzymes: Braftovi can sometimes affect liver function, leading to increased liver enzymes in blood tests.
• Muscle Pain and Weakness: Braftovi may cause muscle-related side effects such as pain, weakness, or inflammation (rhabdomyolysis).
• Changes in Heart Rhythm: In some cases, Braftovi can affect heart rhythm, leading to QT prolongation.
• Eye Problems: Some individuals may experience changes in vision or other eye-related symptoms.
• High Blood Pressure: Braftovi may cause an increase in blood pressure in some people.
• Serious Allergic Reactions: While rare, some individuals may experience severe allergic reactions to Braftovi, which require immediate medical attention.

It’s essential to report any side effects or unusual symptoms to your healthcare provider promptly. They can provide guidance on managing side effects and may adjust your treatment plan if necessary. Additionally, some side effects may require medical intervention or monitoring to prevent complications.

What should I know about storage and disposal of this medication?

Storage:

• Keep Braftovi capsule in their original packaging, tightly closed, and out of reach of children.
• Store Braftovi at room temperature between 68°F to 77°F (20°C to 25°C).
• Avoid exposure to excessive heat or moisture.
• Do not store Braftovi in the bathroom or near the kitchen sink.

Disposal:

• Dispose of unused or expired Braftovi capsule properly, following local regulations or guidelines for medication disposal.
• Do not flush Braftovi capsule down the toilet or pour them into a drain unless instructed to do so.
• Consult with your healthcare provider or pharmacist for guidance on the safe disposal of Braftovi.

In case of emergency/overdose

• In case of an overdose or emergency situation involving Braftovi, seek immediate medical attention or contact your local poison control center.
• Symptoms of overdose may include severe nausea, vomiting, diarrhea, muscle weakness, or other serious side effects.
• Be prepared to provide information about the amount of Braftovi ingested, the timing of ingestion, and any symptoms experienced.

What other information should I know?

• Inform all healthcare providers involved in your care that you are taking Braftovi.
• Attend all scheduled appointments for monitoring and follow-up with your healthcare provider.
• Avoid activities that may increase the risk of injury or bleeding while taking Braftovi, especially if you experience side effects such as dizziness or weakness.
• Carry a list of all medications you are taking, including Braftovi, and inform medical personnel in case of emergency situations.
• Follow all instructions provided by your healthcare provider regarding dosage, administration, and potential side effects of Braftovi.
• Report any new or worsening symptoms to your healthcare provider promptly.

It’s essential to be well-informed about the proper storage, disposal, and management of Braftovi to ensure its safe and effective use. If you have any questions or concerns about Braftovi or its use, do not hesitate to consult with your healthcare provider or pharmacist for clarification and guidance.