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Botulinum Toxin Type A (Generic IncobotulinumtoxinA Injection)

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WARNING

An injection of incobotulinumtoxinA may cause symptoms of botulism, such as severe or life-threatening difficulty breathing or swallowing, to spread from the site of injection. People who experience swallowing problems while using this drug may continue to experience them for several months. To prevent food or liquid from entering their lungs, they might need to be fed through a feeding tube. After receiving an injection of incobotulinumtoxinA, symptoms may appear immediately or weeks later. People of any age receiving treatment for any ailment may have symptoms. The danger is most likely present in kids receiving spasticity treatment (muscle stiffness and tightness). Inform your doctor if you have or have ever had any breathing or swallowing issues, such as asthma or emphysema, or any conditions that affect your muscles or nerves, such as amyotrophic lateral sclerosis (ALS, also known as Lou Gehrig’s disease; condition in which the nerves that control muscle movement slowly die, resulting in the muscles shrinking and weakening), motor neuropathy (condition in which the muscles weaken over time), or myasthenia grav (condition that causes muscle weakness that may improve with activity). Call your doctor right away if you have any of the following symptoms: the inability to control urination, loss of strength or muscle weakness throughout the body, double or blurred vision, drooping eyelids, difficulty breathing, speaking, or eating.

Every time you receive an injection of incobotulinumtoxinA, your doctor will provide you a patient information leaflet (Medication Guide) from the manufacturer. If you have any questions, carefully read the material and contact your doctor or pharmacist. The Medication Guide is also available on the manufacturer’s website or the Food and Drug Administration (FDA) website.

Why is this medication prescribed?

IncobotulinumtoxinA Several conditions are treated by injections.

IncobotulinumtoxinA injection is used to:

  • Treat adults and children 2 years of age and older who experience chronic sialorrhea (constant drooling or excessive salivation);
  • Adults who have spasticity (muscle stiffness and tightness) in their arms should be treated;
  • Address cerebral palsy (a disorder that makes movement and balance difficult) in children 2 years of age and older who do not have spasticity (muscle stiffness and tightness) of the arms;
  • Alleviate the signs and symptoms of cervical dystonia (spasmodic torticollis);
    uncontrolled neck muscle tightness in adults that may result in neck pain and aberrant head positions;
  • Adults should receive treatment for blepharospasm (uncontrollable tightening of the eyelid muscles that can result in abnormal eyelid movements such as blinking and squinting);
  • And in adults, temporarily smooth frown lines (wrinkles between the eyebrows).

The pharmaceutical incobotulinumtoxinA injection belongs to a group of drugs known as neurotoxins. The nerve signals that lead to excessive salivation are blocked when incobotulinumtoxinA injection is delivered into salivary glands. When incobotulinumtoxinA is injected into a muscle, it inhibits the nerve signals that result in the muscle’s irrational contraction and movement.

How should this medicine be used?

Incobotulinumtoxin An injection is a substance that a doctor will combine with liquid before injecting into the salivary glands or a muscle. To treat your disease, your doctor will decide where to inject the medication best. Depending on your condition and the duration of the treatment’s effects, you may need further injections every three to four months.

IncobotulinumtoxinA injection will likely be administered to you by your doctor at first at a low dose, and when you respond to the drug, your doctor will gradually increase the amount.

Botulinum toxin cannot be switched out for another brand or variety.

Your illness won’t be cured, but an injection of incobotulinumtoxinA may help control it. You might not feel the full effects of the incobotulinumtoxinA injection for a few days or perhaps a few weeks.

Other uses for this medicine

Ask your doctor or pharmacist for more details if you believe this drug should be used for something else.

What special precautions should I follow?

Before receiving incobotulinumtoxinA injection,

  • In case you have any additional medications, incobotulinumtoxinA, abobotulinumtoxinA (Dysport), onabotulinumtoxinA (Botox), prabotulinumtoxinA-xvfs (Jeuveau), rimabotulinumtoxinB (Myobloc), or any of the substances in incobotulinumtoxinA injection, inform your doctor and pharmacist. For a list of the ingredients, consult the Medication Guide or speak with your pharmacist.
  • Inform your doctor and pharmacist about any additional prescription and over-the-counter drugs, vitamins, dietary supplements, and herbal products you are now taking or intend to use. Incorporate any of the following: some anticoagulants (‘blood thinners’), drugs for allergies, colds, or sleep, muscle relaxants, and antibiotics like amikacin, clindamycin (Cleocin), colistimethate (Coly-Mycin), gentamicin, lincomycin (Lincocin), neomycin, polymyxin, and streptomycin. Also let your doctor know if you’ve recently had any injections of botulinum toxin-containing products. Your doctor might need to adjust the dosage of your drugs or keep a close eye on you for side effects. Inform your doctor about all the drugs you are taking, even those not on this list, as many other drugs may also interact with incobotulinumtoxinA.
  • Inform your doctor if the area where incobotulinumtoxinA will be injected is swollen or exhibiting other symptoms of infection. Infected areas won’t receive medication injections from your doctor.
  • Inform your doctor if you currently have or previously had bleeding issues, if you’ve ever experienced any side effects from using any botulinum toxin products, or if you’ve had eye or facial surgery.
  • If you are breastfeeding a child or intend to become pregnant, let your doctor know. Call your doctor if you get pregnant while having incobotulinumtoxinA injection.
  • Inform the surgeon or dentist that you are receiving an incobotulinumtoxinA injection if you are undergoing surgery, including dental surgery.
  • It’s important to understand incobotulinumtoxin A shot could result in eyesight problems, muscular wasting across the body, or strength loss. Avoid risky tasks such as operating machinery or operating a vehicle if you experience any of these symptoms.
  • Consult your doctor about stepping up your activities following treatment if you are having incobotulinumtoxinA injection to treat a condition that has impaired your ability to do so. As your body gets used to the effects of your medication, your doctor likely wants you to gradually raise your activity level.

What special dietary instructions should I follow?

Unless your doctor tells you otherwise, continue your normal diet.

What side effects can this medication cause?

Incobotulinumtoxin Injection side effects are possible. Since some adverse effects may be connected to (or occur more frequently in) the portion of the body where you received the injection, ask your doctor the side effects you are most likely to suffer. If any of these symptoms are severe or do not go away, let your doctor know right once:

  • Pain, sensitivity, or bruising where the injection was administered
  • Runny nose, sore throat, or nasal congestion
  • Headache
  • Mouth ache
  • Issues with your teeth or gums
  • Diarrhea
  • Muscle, bone, or joint discomfort
  • Wet eyes
  • Decreased blinking or diminished blinking effectiveness

Some negative effects may be quite detrimental. If you experience any of the symptoms listed below, or any of those in the IMPORTANT WARNING section, call your doctor straight away:

  • Vision alterations
  • Eyelid enlargement
  • Stinging or itchy eye
  • Seizures
  • Stiff neck
  • Breathing difficulty
  • Fainting
  • Dizziness
  • Rash
  • Hives
  • Itching
  • Edoema of the lower legs, ankles, feet, or hands

Other negative effects from incobotulinumtoxinA injections are possible. If you have any strange side effects while taking this medicine, call your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

In case of emergency/overdose

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Additionally, information can be found online at https://www.poisonhelp.org/help. Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

Overdose signs typically do not show up right away after the injection. Tell your doctor straight away if you received too much incobotulinumtoxinA or if you swallowed the drug. Also let them know if you have any of the following symptoms during the following few weeks:

  • Weakness
  • Any difficulty moving your body in any direction
  • Having trouble breathing

What other information should I know?

Keep all of your doctor’s appointments.

Ask your pharmacist any queries you may have regarding the injection of incobotulinumtoxinA.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Xeomin®
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