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Blinatumomab Injection

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Only a medical professional with experience administering chemotherapy drugs should provide blinatumomab injection.

A significant, maybe fatal reaction to blinatumomab injection could develop during the drug’s infusion. Inform your physician if you have ever experienced a negative reaction to blinatumomab or any other medicine. Before each dose of blinatumomab, you will receive a number of drugs to help guard against an allergic reaction. Tell your doctor right away if you suffer any of the following during or after getting blinatumomab: fever, weakness, fatigue, headache, nausea, vomiting, chills, rash, facial swelling, wheezing, or trouble breathing. Your doctor will stop your infusion if you have a severe response and address the associated symptoms.

Additionally, Blinatumomab injection may result in severe, sometimes fatal central nervous system responses. If you experience or have ever experienced seizures, confusion, loss of balance, or problems speaking, let your doctor know. Inform your doctor right once if you have any of the following symptoms: headache, confusion, unsteadiness of balance, uncontrollable trembling of a portion of the body, difficulty speaking, slurred speech, loss of consciousness, trouble sleeping or keeping asleep.

Discuss the potential risks of using blinatumomab injection with your doctor.

Why is this medication prescribed?

When other treatments have failed or the patient’s acute lymphocytic leukaemia (ALL; a kind of cancer of the white blood cells) has reappeared, blinatumomab is used to treat both adults and children. When ALL is in remission (when the cancer’s symptoms and signs have decreased or disappeared but some residual cancerous tissue is still present), both adults and children can be treated with blinatumomab. Bispecific T-cell Engager Antibodies are a group of drugs that includes blinatumomab. It operates by reducing or preventing the growth of cancer cells within your body.

How should this medicine be used?

In a hospital or other healthcare setting, as well as occasionally at home, a doctor or nurse will mix a powder with liquid and slowly inject it intravenously (into a vein). This medicine is administered continuously for 4 weeks, followed by a 2 to 8-week break. A cycle is the name given to this therapy time, and cycles may be repeated as necessary. How you react to the drug will determine how long the treatment will last.

If you have certain adverse effects, your doctor may decide to postpone your treatment, alter your dose, or end it altogether. It is crucial that you communicate your feelings to your doctor throughout your blinatumomab injectable treatment.

Other uses for this medicine

Ask your doctor or pharmacist for more details if you believe this drug should be used for something else.

What special precautions should I follow?

Before receiving blinatumomab injection,

  • If you have any allergies, including to benzyl alcohol, blinatumomab, other drugs, or any of the other ingredients in blinatumomab injection, notify your doctor right away. Request a list of the components from your pharmacist.
  • Inform your doctor and pharmacist about any additional prescription and over-the-counter drugs, vitamins, dietary supplements, and herbal products you are now taking or intend to use. Incorporate any of the following: Warfarin or cyclosporine (Gengraf, Neoral, Sandimmune) (Coumadin, Jantoven). Tell your doctor about all the drugs you are taking, including any not on this list, since many other drugs may also interact with blinatumomab. Your physician might need to adjust the dosage of your drugs or keep a close eye on you for side effects.
  • If you have an infection or have ever had one that keeps coming back, let your doctor know. Tell your doctor if you have ever undergone brain radiation therapy, underwent chemotherapy, or have ever experienced liver illness.
  • If you are pregnant or plan to become pregnant, let your doctor know. Before receiving this drug, a pregnancy test will be required of you. Pregnancy should be avoided while receiving blinatumomab treatment and for at least two days after the last dosage. Discuss the various birth control methods that will work for you with your doctor. Call your doctor if you become pregnant while taking blinatumomab. The foetus may suffer from blinatumomab.
  • Describe to your doctor if you are nursing a baby. While using blinatumomab and for at least two days following your last dose, refrain from breastfeeding.
    The injection of blinatumomab may cause you to feel sleepy. While using this drug, avoid operating machinery or driving a car.
  • Avoid getting any shots without first consulting your doctor. If you have had a vaccination within the last two weeks, let your doctor know. Your doctor will advise you on the best time to receive a vaccine following your final dose.

What special dietary instructions should I follow?

Keep eating normally unless your doctor instructs you otherwise.

What side effects can this medication cause?

The injection of blinatumomab may have adverse effects. If any of these symptoms are severe or do not go away, let your doctor know right once:

  • Constipation
  • Vomiting
  • Weight gain
  • Joint, muscular, or back pain
  • Edoema of the lower legs, lower arms, feet, ankles, or hands
  • The injection site hurts

Some adverse effects can be very harmful. Call your doctor right away or seek emergency medical attention if you experience any of these symptoms or those noted in the IMPORTANT WARNING or SPECIAL PRECAUTIONS sections:

  • Chest discomfort
  • Tingling or numbness in the hands, feet, arms, or legs
  • Breathing difficulty
  • Persistent stomach ache that may radiate to the back and come on with or without nausea and vomiting
  • Fever, a sore throat, a cough, and other infection-related symptoms

Other negative effects from blinatumomab injection are possible. If you have any strange side effects while taking this medicine, call your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

In case of emergency/overdose

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Additionally, information can be found online at Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

Overdose signs could include the following:

  • Fever
  • Body part shaking that is uncontrollable
  • Headache

What other information should I know?

Keep all of your appointments with your physician and the lab. Before, during, and after your treatment, your doctor will request specific lab tests to monitor your body’s reaction to the blinatumomab injection and to manage side effects before they worsen.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Blincyto®
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