Never administer penicillin G benzathine or penicillin G procaine injection intravenously (into a vein), as this may result in significant or fatal side effects.

To treat and prevent some bacterial infections, penicillin G benzathine and penicillin G procaine injection are utilised. Sexually transmitted infections (STDs) and the first stages of some dangerous infections shouldn’t be treated with penicillin G benzathine or penicillin G procaine injection. The class of drugs known as penicillins includes penicillin G benzathine and penicillin G procaine injection. It functions by eradicating the infection-causing germs.

Colds, the flu, and other viral infections cannot be treated with penicillin G benzathine or penicillin G procaine injection, among other antibiotics. Antibiotic use that is not necessary raises the likelihood of developing a later infection that is resistant to antibiotic treatment.

A doctor or nurse in a medical setting can provide penicillin G benzathine and penicillin G procaine injection as a suspension (liquid) into the buttocks or thigh muscles. You can provide penicillin G benzathine and penicillin G procaine injection in one dosage or in two doses spaced two days apart. You can occasionally require additional doses spaced two to three days apart.

During the first several days of treatment with penicillin G benzathine and penicillin G procaine injection, you should start to feel better. Call your doctor if your symptoms don’t go away or get worse.

Keep all scheduled visits to obtain your doses of penicillin G benzathine and penicillin G procaine injection if your doctor has advised you that you will require extra doses, even if you feel better. Your illness could not be entirely treated if you stop using penicillin G benzathine and penicillin G procaine injection too soon or skip doses, and the bacteria might develop antibiotic resistance.

Ask your doctor or pharmacist for more details if you believe this drug should be used for something else.

Before receiving penicillin G benzathine and penicillin G procaine injection,

• Inform your doctor and pharmacist if you have any allergies to cephalosporin antibiotics including cefaclor, cefadroxil, cefzolin (Ancef, Kefzol), cefditoren (Spectracef), cefpime (Maxipime), and cefixime as well as penicillin G benzathine and G procaine injection (Suprax), procaine, any other drugs, or the antibiotics cefotaxime (Claforan), cefoxitin, cefpodoxime, cefprozil, ceftazidime (Fortaz, Tazicef), ceftibuten (Cedax), ceftriaxone (Rocephin), cefuroxime (Ceftin, Zinacef), and cephalexin (Keflex). If you are unsure whether a drug you are allergic to falls under one of these categories, see your doctor or pharmacist. If you have any allergies to any of the components of penicillin G benzathine or penicillin G procaine injection, let your doctor know. Request a list of the components from your pharmacist.
• Inform your doctor and pharmacist about any additional prescription and over-the-counter drugs, vitamins, dietary supplements, and herbal products you are now taking or intend to use. Mention tetracycline and probenecid (Probalan) (Achromycin). Your physician might need to adjust the dosage of your drugs or keep a close eye on you for side effects.
• If you have or have ever had asthma, allergies, hay fever, hives, or renal disease, let your doctor know.
• Inform your physician if you are nursing a baby, intend to get pregnant, or are already pregnant. Call your doctor if you conceive while having penicillin G benzathine and penicillin G procaine injection.

Keep eating normally unless your doctor instructs you otherwise.

Call your doctor as soon as you can if you are unable to keep a scheduled appointment to receive penicillin G benzathine and penicillin G procaine injection.

Penicillin G procaine injection and Penicillin G benzathine may have adverse effects. If any of these symptoms are severe or do not go away, let your doctor know right once:

• Nausea
• Vomiting
• Where the drug was injected, there may be discomfort, swelling, a lump, bleeding, or bruises

Some adverse effects can be very harmful. Call your doctor right away if you encounter any of these symptoms, or seek emergency care:

• Rash
• Hives
• Itching
• Breathing or swallowing challenges
• Edoema of the hands, feet, ankles, lower legs, cheeks, neck, tongue, lips, and eyes
• Hoarseness
• Throat soreness
• Chills
• Fever
• Headache
• Joint or muscle ache
• Weakness
• Rapid heart rate
• Severe diarrhoea (watery or bloody stools) that may persist for up to 2 months or longer after your treatment, along with fever and stomach cramps.
• Lower back discomfort that started suddenly, along with numbness, muscle weakness, and tingling
• Skin discoloration in the drug injection site that is blue or black
• Blistering, peeling, or shedding of the skin where the injection site for the medicine was
• Arm or leg numbness where the medicine was injected
• Severe agitation, disorientation, hearing voices or seeing things that aren’t there, or fear of passing away

Other side effects could be brought on by penicillin G benzathine and penicillin G procaine injection. If you experience any strange issues while taking this medicine, contact your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Additionally, information can be found online at https://www.poisonhelp.org/help. Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

Overdose signs could include the following:

• Twitching
• Seizures

Keep all of your appointments with your physician and the lab. To determine how your body reacts to injections of penicillin G procaine and penicillin G benzathine, your doctor may request specific lab tests.

Any queries you may have regarding penicillin G benzathine and penicillin G procaine injection should be directed to your pharmacist.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.