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Bezlotoxumab Injection

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Why is this medication prescribed?

Bezlotoxumab injection is used to lower the chance of recurrence of Clostridium difficile infection (C. difficile or CDI; a type of bacterium that can cause serious or life-threatening diarrhoea in susceptible individuals who are also receiving an antibiotic to treat Clostridium difficile). Monoclonal antibodies are a class of drugs that includes bezlotoxumab. To block a C. difficile toxin’s negative effects on the body, it functions by attaching to it.

How should this medicine be used?

Bezlotoxumab is administered intravenously (into a vein) during a 60-minute period as a solution (liquid). A physician or nurse will provide one dose of bezlotoxumab.

For C. difficile infection, bezlotoxumab injection is not a substitute for antibiotic therapy; keep up with your antibiotic regimen as prescribed by your doctor.

Other uses for this medicine

Ask your doctor or pharmacist for more details if you believe this drug should be used for something else.

What special precautions should I follow?

Before receiving bezlotoxumab injection,

  • If you have an allergy to bezlotoxumab, any other drugs, or any of the substances in bezlotoxumab infusion, notify your doctor right away. Request a list of the components from your pharmacist.
  • Inform your doctor and pharmacist about any additional prescription and over-the-counter drugs, vitamins, dietary supplements, and herbal products you are now taking or intend to use. Your physician might need to adjust the dosage of your drugs or keep a close eye on you for side effects.
  • Tell your doctor whether you now have heart failure or have ever had it.
  • Inform your physician if you are nursing a baby, intend to get pregnant, or are already pregnant.

What side effects can this medication cause?

The injection of bezlotoxumab may have adverse effects. If any of these symptoms are severe or do not go away, let your doctor know right once:

  • Nausea
  • Fever

Some adverse effects can be very harmful. Call your doctor right away if any of these symptoms occur to you:

  • Respiratory issues or lack of breath
  • Edoema of the stomach, legs, ankles, or feet

Other negative effects of bezlotoxumab injection are also possible. If you have any strange side effects while taking this medicine, call your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

In case of emergency/overdose

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Additionally, information can be found online at https://www.poisonhelp.org/help. Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

What other information should I know?

Keep all of your doctor’s appointments.

All inquiries regarding bezlotoxumab injection should be directed to your pharmacist.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Zinplava®
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