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You run the danger of developing a blood clot in or near your spine if you receive epidural, spinal, or a spinal puncture while taking a “blood thinner” like betrixaban, which might leave you paralysed. Inform your doctor if you have a residual epidural catheter, have undergone spinal surgery, have undergone repeated epidural or spinal punctures, or have any of these conditions. Inform your doctor and pharmacist if you’re taking aspirin, amiodarone (Pacerone, Nexterone), anagrelide (Agrylin), ibuprofen (Advil, Motrin, other), indomethacin (Indocin, Tivorbex), ketoprofen, or naproxen (Aleve, Anaprox, other); clopidogrel (Plavix), dipyridamole (Persantine), eptifibatide (Integrilin), heparin, ketoconazole (Nizoral, Extina), prasugrel (Effient), azithromycin (Zithromax, Zmax), cilostazol (Pletal), clarithromycin (Biaxin, in Prevpac); selective serotonin reuptake inhibitors (SSRIs), such as citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem, Selfemra, in Symbyax), fluvoxamine (Luvox), luvoxamine (Luvox), paroxetine (Brisdelle, Paxil, Pexeva), and sertraline (Zoloft); and SNRIs such as duloxetine (Cymbalta), desvenlafaxine (Khedezla, Pristiq), levomilnacipran (Fetzima), milnacipran (Savella), and venlafaxine (Effexor); ticagrelor (Brilinta); ticlopidine; tirofiban (Aggrastat); verapamil (Verelan, Calan); and warfarin (Coumadin, Jantoven). If you have any of the following indications or symptoms, contact your doctor right away: Back pain, muscle aches, tingling or numbness (especially in the legs and feet), inability to control bowels or bladder, or a weakness in your legs are some symptoms that you might have.

Whenever you need a prescription refill for betrixaban, your doctor or pharmacist will provide you the manufacturer’s patient information leaflet (Medication Guide). If you have any questions, carefully read the material and contact your doctor or pharmacist. The Medication Guide is also available on the manufacturer’s website or the Food and Drug Administration (FDA) website (

Consult your physician about the dangers of taking betrixaban.

Why is this medication prescribed?

Betrixaban is used to prevent deep vein thrombosis (DVT), a blood clot that typically forms in the leg, and pulmonary embolism (PE), a blood clot that forms in the lung, in patients who are being treated in hospitals for serious illnesses and are at risk of doing so because of their limited mobility or other risk factors. A group of drugs known as factor Xa inhibitors includes apixaban. It functions by inhibiting a certain natural compound that promotes the formation of blood clots.

How should this medicine be used?

Betrixaban is available as a capsule to be swallowed. It is typically given once day for 35 to 42 days with food. Betrixaban should be taken every day at about the same time. Ask your doctor or pharmacist to explain any instructions on your prescription label that you are unsure about following. Betrixaban should be taken as prescribed. Never take it in larger or less amounts or more frequently than directed by your doctor.

Betrixaban should be taken even if you feel OK. Without consulting your doctor, do not discontinue taking betrixaban. Your chance of developing a blood clot may rise if you stop taking betrixaban.

Other uses for this medicine

Ask your doctor or pharmacist for more details if you believe this drug should be used for something else.

What special precautions should I follow?

Before taking betrixaban,

  • If you have an allergy to betrixaban, any other drugs, or any of the ingredients in betrixaban capsules, tell your doctor and pharmacist right away. For a list of the ingredients, consult the Medication Guide or speak with your pharmacist.
  • Inform your doctor and pharmacist about any additional prescription and over-the-counter drugs, vitamins, dietary supplements, and herbal products you are now taking or intend to use. Mention all of the drugs that are listed in the IMPORTANT WARNING section. and Your physician might need to adjust the dosage of your drugs or keep a close eye on you for side effects. Be remember to inform your doctor about any drug you are taking, even those not on this list, as many other drugs may also interact with betrixaban.
  • Inform your doctor if you develop persistent bleeding in any other parts of your body. Your physician will probably advise against taking betrixaban.
  • Tell your doctor if you have an artificial heart valve, have ever had a bleeding problem, have liver or kidney issues, or any of the above.
  • Inform your doctor if you are breastfeeding a kid or plan to get pregnant. If you become pregnant while using betrixaban, call your doctor.
  • If you are getting surgery, including dental surgery, let your doctor or dentist know that you are taking betrixaban.
  • Call your doctor as soon as possible if you fall or damage yourself, especially if you hit your head. You might require examination by your doctor.

What special dietary instructions should I follow?

Keep eating normally unless your doctor instructs you otherwise.

What should I do if I forget a dose?

On the same day, take the missed dose as soon as you remember. If the next dose is soon due, skip the missed one and carry on with your regular dosing plan. To make up for a missing dose, do not take a second one.

What side effects can this medication cause?

Betrixaban might have negative effects. If any of these symptoms are severe or do not go away, let your doctor know right once:

  • Constipation
  • Diarrhea
  • Nausea
  • Uncomfortable or frequent urination

Some adverse effects can be very harmful. Betrixaban should be stopped immediately if you develop any of the following symptoms or any of those mentioned in the IMPORTANT WARNING section. You should also seek emergency medical attention if necessary.

  • Bluish gums
  • Several nosebleeds
  • Bleeding during menstruation that is heavier than usual
  • Urine that is brown, pink, or red
  • Tarry, crimson or black stools
  • Blood or blood clots being coughed up
  • Vomit blood or what appears to be coffee grinds
  • Unexpected joint discomfort, soreness, or edoema
  • Headache
  • Weakness or vertigo

If you are cut or injured, it could take longer than usual for the bleeding to cease since betrixaban stops blood from clotting normally. Additionally, this drug may make it easier for you to bleed or bruise. If bleeding or bruising is unusual, severe, or uncontrollable, call your doctor straight once.

Keep eating normally unless your doctor instructs you otherwise. If you experience any strange issues while taking this medicine, contact your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

What should I know about storage and disposal of this medication?

Keep this medication tightly closed in the original container and out of the reach of children. Store it away from excessive heat and moisture at room temperature (not in the bathroom).

As many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for young children to open, it is crucial to keep all medications out of sight and out of reach of children. Always lock safety caps and promptly stash medication up and away from young children where it is out of their sight and reach to prevent poisoning.

Unused prescriptions must be disposed of carefully to prevent pets, kids, and other people from ingesting them. You should not, however, dispose of this medication in the toilet. Instead, utilising a medicine take-back programme is the easiest approach to get rid of your medication. To find out about take-back programmes in your area, speak with your pharmacist or the garbage/recycling department in your city. If you do not have access to a take-back programme, see the FDA’s Safe Disposal of Medicines website at for additional information.

In case of emergency/overdose

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Additionally, information can be found online at Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

Overdose signs could include the following:

  1. Bleeding

What other information should I know?

Keep all of your doctor’s appointments.

No one else should take your medication. Any queries you may have regarding medication refills should be directed to your pharmacist.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Bevyxxa®
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